Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Aijuan Qu"'
Autor:
Jinhang Zhang, Ya Huang, Hong Li, Pengfei Xu, Qinhui Liu, Yang Sun, Zijing Zhang, Tong Wu, Qin Tang, Qingyi Jia, Yan Xia, Ying Xu, Xiandan Jing, Jiahui Li, Li Mo, Wen Xie, Aijuan Qu, Jinhan He, Yanping Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Pregnane X receptor (PXR) has been reported to regulate glycolipid metabolism. The dysfunction of intestinal barrier contributes to metabolic disorders. However, the role of intestinal PXR in metabolic diseases remains largely unknown. Here,
Externí odkaz:
https://doaj.org/article/c585118dd2cb442cb8c2dbc63eae7924
Autor:
Shicheng Fan, Yue Gao, Pengfei Zhao, Guomin Xie, Yanying Zhou, Xiao Yang, Xuan Li, Shuaishuai Zhang, Frank J. Gonzalez, Aijuan Qu, Min Huang, Huichang Bi
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 7, Pp 2992-3008 (2024)
Fenofibrate, a peroxisome proliferator-activated receptor α (PPARα) agonist, is widely prescribed for hyperlipidemia management. Recent studies also showed that it has therapeutic potential in various liver diseases. However, its effects on hepatom
Externí odkaz:
https://doaj.org/article/ffaca6e6008341c9ac5e6816bba27d5b
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 13, Iss 12, Pp 1510-1525 (2023)
The central nervous system is susceptible to the modulation of various neurophysiological processes by the cytochrome P450 enzyme (CYP), which plays a crucial role in the metabolism of neurosteroids. The antiepileptic drug phenytoin (PHT) has been ob
Externí odkaz:
https://doaj.org/article/9e529ab9352f44e3b39bcf7c2a34cc59
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Transverse aortic constriction (TAC) is a widely-used animal model for pressure overload-induced cardiac hypertrophy and heart failure (HF). The severity of TAC-induced adverse cardiac remodeling is correlated to the degree and duration of aorta cons
Externí odkaz:
https://doaj.org/article/981a0996d69c428a80c04c5e15a7af68
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Vascular repair upon vessel injury is essential for the maintenance of arterial homeostasis and function. Stem/progenitor cells were demonstrated to play a crucial role in regeneration and replenishment of damaged vascular cells during vascular repai
Externí odkaz:
https://doaj.org/article/2b0894c9ffcd40c8aaa48c1f02a46fd4
Autor:
Yan Duan, Dan Qi, Ye Liu, Yanting Song, Xia Wang, Shiyu Jiao, Huihua Li, Frank J. Gonzalez, Yongfen Qi, Qingbo Xu, Jie Du, Aijuan Qu
Publikováno v:
Biochemistry and Biophysics Reports, Vol 27, Iss , Pp 101091- (2021)
Peroxisome proliferator-activated receptor (PPAR) α is widely expressed in the vasculature and has pleiotropic and lipid-lowering independent effects, but its role in the growth and function of vascular smooth muscle cells (VSMCs) during vascular pa
Externí odkaz:
https://doaj.org/article/4c43e16217e44761a25efcce256af930
Autor:
Ye Liu, Yan Duan, Nan Zhao, Xinxin Zhu, Xiaoting Yu, Shiyu Jiao, Yanting Song, Li Shi, Yutao Ma, Xia Wang, Baoqi Yu, Aijuan Qu
Publikováno v:
Antioxidants, Vol 11, Iss 12, p 2378 (2022)
Vascular remodeling is the fundamental basis for hypertensive disease, in which vascular smooth muscle cell (VSMC) dysfunction plays an essential role. Previous studies suggest that the activation of peroxisome proliferator-activated receptor α (PPA
Externí odkaz:
https://doaj.org/article/9f103e609b0c4cbea3d51533ab80c612
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Background: Adropin, a peptide translated from the Energy Homeostasis Associated gene (ENHO), was mainly expressed in the liver and was a regulator in metabolic and energy homeostasis. This study aims to investigate the correlation between adropin an
Externí odkaz:
https://doaj.org/article/3435eaad29484feaac16cc3bb04f2192
Autor:
Ming Wei, Xia Wang, Yanting Song, Di Zhu, Dan Qi, Shiyu Jiao, Guomin Xie, Ye Liu, Baoqi Yu, Jie Du, Yuji Wang, Aijuan Qu
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Objective: Neutrophil infiltration plays an important role in the initiation and development of abdominal aortic aneurysm (AAA). Recent studies suggested that neutrophils could release neutrophil extracellular traps (NETs), leading to tissue injury i
Externí odkaz:
https://doaj.org/article/5d4ea9b06681430085ff8353341abfee
Autor:
Hong Li, Jing Shen, Tong Wu, Jiangying Kuang, Qinhui Liu, Shihai Cheng, Shiyun Pu, Lei Chen, Rui Li, Yanping Li, Min Zou, Zhiyong Zhang, Wei Jiang, Aijuan Qu, Jinhan He
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
ObjectiveThe aim of this study was to investigate whether the nuclear receptor farnesoid X receptor (FXR) could regulate FNDC5/Irisin expression and the role of Irisin in hyperlipidemia and atherosclerosis in ApoE-/- mice.Methods and ResultsWe treate
Externí odkaz:
https://doaj.org/article/7943583ff535430187f1f89165526aab