Výsledky vyhledávání

Novel Pyrazole Carboxamide Containing a Diarylamine Scaffold Potentially Targeting Fungal Succinate Dehydrogenase: Antifungal Activity and Mechanism of Action

Autor: Yongtian Zhao, Aigui Zhang, Xinge Wang, Ke Tao, Hong Jin, Taiping Hou

Publikováno v: Journal of agricultural and food chemistry. 70(42)

Succinate dehydrogenase (SDH) is known as an ideal target for the development of novel fungicides. Over the years, a series of novel pyrazole carboxamides containing a diarylamine scaffold have been reported as potent SDH inhibitors (SDHIs) in our la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5e78ab952b6f93ddc9896305502bdec
https://pubmed.ncbi.nlm.nih.gov/36250688

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Anomeric and Enantiomeric 2’‐Deoxycytidines: Base Pair Stability in the Absence and Presence of Silver Ions

Autor: Simone Budow-Busse, Frank Seela, Peter Leonard, Aigui Zhang

Publikováno v: Chemistry (Weinheim an Der Bergstrasse, Germany)

Dodecamer duplex DNA containing anomeric (α/β‐d) and enantiomeric (β‐l/β‐d) 2’‐deoxycytidine mismatches was studied with respect to base pair stability in the absence and presence of silver ions. Stable duplexes with silver‐mediated c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b11fb87bd3675baf101b9dabbdc42d3
http://europepmc.org/articles/PMC8362019

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DNA with Purine-Purine Base Pairs: Size and Position of Isoguanine and 8-Aza-7-deazaisoguanine Clickable Residues Control the Molecular Recognition of Guanine and 5-Aza-7-deazaguanine

Autor: Dasharath Kondhare, Aigui Zhang, Peter Leonard, Frank Seela

Publikováno v: The Journal of organic chemistry. 87(16)

Purine-purine base pairs represent an alternative recognition system to the purine-pyrimidine pairing reported by Watson and Crick. Modified purines are the source for non-canonical interactions. To mimic dG-dC interactions, 2'-deoxyisoguanosine (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf18b8045b4fa300c5164545ac2860b
https://pubmed.ncbi.nlm.nih.gov/35948421

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DNA Strand Displacement with Base Pair Stabilizers: Purine-2,6-Diamine and 8-Aza-7-Bromo-7-Deazapurine-2,6-Diamine Oligonucleotides Invade Canonical DNA and New Fluorescent Pyrene Click Sensors Monitor the Reaction

Autor: Aigui Zhang, Dasharath Kondhare, Peter Leonard, Frank Seela

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 28(72)

Purine-2,6-diamine and 8-aza-7-deaza-7-bromopurine-2,6-diamine 2'-deoxyribonucleosides (1 and 2) were implemented in isothermal DNA strand displacement reactions. Nucleoside 1 is a weak stabilizer of dA-dT base pairs, nucleoside 2 evokes strong stabi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea83c8cc6a706549683418b6eeea8f5e
https://pubmed.ncbi.nlm.nih.gov/36178316

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Anomeric DNA Strand Displacement with α‐D Oligonucleotides as Invaders and Ethidium Bromide as Fluorescence Sensor for Duplexes with α/β‐, β/β‐ and α/α‐D Configuration

Autor: Aigui Zhang, Dasharath Kondhare, Peter Leonard, Frank Seela

Publikováno v: Chemistry – A European Journal. 28

DNA strand displacement is a technique to exchange one strand of a double stranded DNA by another strand (invader). It is an isothermal, enzyme free method driven by single stranded overhangs (toeholds) and is employed in DNA amplification, mismatch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89cbc5bf6ceb821dc9b7db6bcad747f1
https://doi.org/10.1002/chem.202201294

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5‐Aza‐7‐deazaguanine–Isoguanine and Guanine–Isoguanine Base Pairs in Watson–Crick DNA: The Impact of Purine Tracts, Clickable Dendritic Side Chains, and Pyrene Adducts

Autor: Peter Leonard, Aigui Zhang, Dasharath Kondhare, Frank Seela

Publikováno v: Chemistry (Weinheim an Der Bergstrasse, Germany)

The Watson–Crick coding system depends on the molecular recognition of complementary purine and pyrimidine bases. Now, the construction of hybrid DNAs with Watson–Crick and purine–purine base pairs decorated with dendritic side chains was perfo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbea7bae089bcbef3be0bc19af345c9d
http://europepmc.org/articles/PMC8251886

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The 2‐Amino Group of 8‐Aza‐7‐deaza‐7‐bromopurine‐2,6‐diamine and Purine‐2,6‐diamine as Stabilizer for the Adenine–Thymine Base Pair in Heterochiral DNA with Strands in Anomeric Configuration

Autor: Peter Leonard, Frank Seela, Dasharath Kondhare, Yingying Chai, Aigui Zhang

Publikováno v: Chemistry (Weinheim an Der Bergstrasse, Germany)

Stabilization of DNA is beneficial for many applications in the fields of DNA therapeutics, diagnostics, and materials science. Now, this phenomenon is studied on heterochiral DNA, an autonomous DNA recognition system with complementary strands in α

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40aa014dfbbfd1313ae769bbb22c3493
https://doi.org/10.1002/chem.202004221

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Anomeric DNA: Functionalization of α-d Anomers of 7-Deaza-2'-deoxyadenosine and 2'-Deoxyuridine with Clickable Side Chains and Click Adducts in Homochiral and Heterochiral Double Helices

Autor: Aigui Zhang, Peter Leonard, Frank Seela

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 28(9)

Anomeric base pairs in heterochiral DNA with strands in the α-d and β-d configurations and homochiral DNA with both strands in α-d configuration were functionalized. The α-d anomers of 2'-deoxyuridine and 7-deaza-2'-deoxyadenosine were synthesize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb699d39bbe17a080f229555b65ede2
https://pubmed.ncbi.nlm.nih.gov/34878201

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