Serrated colorectal cancer: preclinical models and molecular pathways

Autor: Aiderus, Aziz, Barker, Nick, Tergaonkar, Vinay

Publikováno v: In Trends in Cancer January 2024 10(1):76-91

Transposon mutagenesis identifies cooperating genetic drivers during keratinocyte transformation and cutaneous squamous cell carcinoma progression.

Autor: Aziz Aiderus, Justin Y Newberg, Liliana Guzman-Rojas, Ana M Contreras-Sandoval, Amanda L Meshey, Devin J Jones, Felipe Amaya-Manzanares, Roberto Rangel, Jerrold M Ward, Song-Choon Lee, Kenneth Hon-Kim Ban, Keith Rogers, Susan M Rogers, Luxmanan Selvanesan, Leslie A McNoe, Neal G Copeland, Nancy A Jenkins, Kenneth Y Tsai, Michael A Black, Karen M Mann, Michael B Mann

Publikováno v: PLoS Genetics, Vol 17, Iss 8, p e1009094 (2021)

The systematic identification of genetic events driving cellular transformation and tumor progression in the absence of a highly recurrent oncogenic driver mutation is a challenge in cutaneous oncology. In cutaneous squamous cell carcinoma (cuSCC), t

Externí odkaz: https://doaj.org/article/9ca296e0d3ca42438be6049b510b1dcf

Transposon mutagenesis identifies cooperating genetic drivers during keratinocyte transformation and cutaneous squamous cell carcinoma progression.

Autor: Aiderus, Aziz¹ (AUTHOR), Newberg, Justin Y.^1,2 (AUTHOR), Guzman-Rojas, Liliana² (AUTHOR), Contreras-Sandoval, Ana M.¹ (AUTHOR), Meshey, Amanda L.¹ (AUTHOR), Jones, Devin J.² (AUTHOR), Amaya-Manzanares, Felipe² (AUTHOR), Rangel, Roberto² (AUTHOR), Ward, Jerrold M.³ (AUTHOR), Lee, Song-Choon³ (AUTHOR), Ban, Kenneth Hon-Kim³ (AUTHOR), Rogers, Keith³ (AUTHOR), Rogers, Susan M.³ (AUTHOR), Selvanesan, Luxmanan⁴ (AUTHOR), McNoe, Leslie A.⁴ (AUTHOR), Copeland, Neal G.^2,3 (AUTHOR), Jenkins, Nancy A.^2,3 (AUTHOR), Tsai, Kenneth Y.^5,6,7 (AUTHOR), Black, Michael A.⁴ (AUTHOR), Mann, Karen M.^1,2,3,7,8,9 (AUTHOR)

Publikováno v: PLoS Genetics. 8/16/2021, Vol. 17 Issue 8, p1-34. 34p.

Data from A PAM50-Based Chemoendocrine Score for Hormone Receptor–Positive Breast Cancer with an Intermediate Risk of Relapse

Autor: Emilio Alba, Charles M. Perou, J. Michael Dixon, Miguel Martín, Eva Carrasco, Mitch Dowsett, Barbara Adamo, Rosalía Caballero, Abdul Aziz Bin Aiderus, Begoña Jimenez, Nuria Ribelles, Joel S. Parker, Laia Paré, Montserrat Muñoz, Arrate Plazaola, Pedro Sánchez-Rovira, José Ignacio Chacón, Angels Arcusa, Juan de la Haba-Rodríguez, Joan Albanell, Lourdes Calvo, Anita K. Dunbier, Arran K. Turnbull, Ana Lluch, Aleix Prat

Purpose: Hormone receptor–positive (HR+) breast cancer is clinically and biologically heterogeneous, and subgroups with different prognostic and treatment sensitivities need to be identified.Experimental Design: Research-based PAM50 subtyping and e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0209d69bf320217f21340eee1abe56
https://doi.org/10.1158/1078-0432.c.6525374.v1

Oestrogen deprivation induces chemokine production and immune cell recruitment in in vitro and in vivo models of oestrogen receptor-positive breast cancer

Autor: Roslyn A. Kemp, Virginia Niemi, Lyn M. Wise, Aziz Aiderus, Anita K. Dunbier, Jody Hazlett, Katelyn Powell

Publikováno v: Breast Cancer Research : BCR
Breast Cancer Research, Vol 23, Iss 1, Pp 1-15 (2021)

Background Oestrogen receptor-positive (ER+) breast cancer is commonly treated using endocrine therapies such as aromatase inhibitors which block synthesis of oestradiol, but the influence of this therapy on the immune composition of breast tumours h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88bb3395f2835fbef8b79c2c7964ea5
https://pubmed.ncbi.nlm.nih.gov/34602068