Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Aiden A, Flynn"'
Autor:
Robert I. Shortman, Balaji Ganeshan, Aiden A. Flynn, Peter J. Ell, Lynn Hurrell, Toby M. Maher, Nicholas Screaton, Pauline T. Lukey, Thida Win, Kris Thielemans, Francesco Fraioli, Alaleh Rashidnasab, Beverley F. Holman, Raymondo Endozo, Joanna C. Porter, Brian Hutton, Ashley M. Groves
PURPOSE: There is a lack of prognostic biomarkers in idiopathic pulmonary fibrosis (IPF) patients. The objective of this study is to investigate the potential of 18F-FDG-PET/ CT to predict mortality in IPF. METHODS: A total of 113 IPF patients (93 ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a17f30e996bf8a9bfcc847f5a30d73
http://hdl.handle.net/10044/1/59929
http://hdl.handle.net/10044/1/59929
Autor:
Anne-Marie Russell, Jane H Bentley, Diana Julie Leeming, Rebecca Braybrooke, Pauline T. Lukey, Richard P. Marshall, Athol U. Wells, Richard Hubbard, Philip L. Molyneaux, Morten A. Karsdal, Tricia M. McKeever, R. Gisli Jenkins, Aiden A. Flynn, Gauri Saini, Toby M. Maher, Juliet Kay Simpson
Summary Background Idiopathic pulmonary fibrosis, a progressive and inevitably fatal disorder, has a highly variable clinical course. Biomarkers that reflect disease activity are urgently needed to inform patient management and for use as biomarkers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b607dd5095ab1a358860bb39fc4052b6
http://hdl.handle.net/10044/1/32192
http://hdl.handle.net/10044/1/32192
Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 19:371-377
The development of novel, systemically administered radionuclide therapies (such as radioimmunotherapy) relies on the ability to predict dose-limiting toxicity to normal tissue. Where the kidney is the principal route of excretion of the radionuclide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0223f079e88b0fba0d36c9dcb56a4baf
https://doi.org/10.1089/1084978041425052
https://doi.org/10.1089/1084978041425052
Autor:
Geoffrey M. Boxer, Ethaar El-Emir, Jason L. J. Dearling, A J Green, Aiden A. Flynn, Robert Boden, Richard H. J. Begent, R. Barbara Pedley
Publikováno v:
Radiation Research. 159:182-189
The therapeutic efficacy of radiolabeled antibody fragments can be limited by nephrotoxicity, particularly when the kidney is the major route of extraction from the circulation. Conventional dose estimates in kidney assume uniform dose deposition, bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2342c7e062e83f625ef681161eba92
https://doi.org/10.1667/0033-7587(2003)159[0182:tnoadi]2.0.co
https://doi.org/10.1667/0033-7587(2003)159[0182:tnoadi]2.0.co
Autor:
James A. Raleigh, Ethaar El-Emir, Geoffrey M. Boxer, Aiden A. Flynn, Sally A. Hill, Jason L. J. Dearling, Richard H. J. Begent, R. Barbara Pedley, Reeya Motha, Sam Stuart
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 54:1524-1531
Purpose: Tumor heterogeneity necessitates the use of combined therapies. We have shown that combining antibody-directed therapy with antivascular agents converts a subcurative to a curative treatment. The purpose of this study was to investigate, by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62b9e637259b050b1ceef15a50e36c1
https://doi.org/10.1016/s0360-3016(02)03923-8
https://doi.org/10.1016/s0360-3016(02)03923-8
Autor:
Steven D. Averbuch, Breon Burgess, Federico Goodsaid, Alfons Lieftucht, Sean Xinghua Hu, Ernst R. Berndt, Jian Wang, Judy Milloy, Mark R. Trusheim, Theresa Long, Aiden A. Flynn, Abhijit Mazumder, Michael C. Palmer, David Swank, Peter M. Shaw
Publikováno v:
Nature reviews. Drug discovery. 10(11)
Co-developing a drug with a diagnostic to create a stratified medicine — a therapy that is targeted to a specific patient population on the basis of a clinical characteristic such as a biomarker that predicts treatment response — presents challen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25cc17bb78551391a955251faa5558ef
https://pubmed.ncbi.nlm.nih.gov/22037040
https://pubmed.ncbi.nlm.nih.gov/22037040
Autor:
Aiden A. Flynn
Publikováno v:
Drug discovery today. 16(19-20)
Pharmacogenetics (PGx) is increasingly used as a way to target treatment to patients who are most likely to benefit. To date, PGx has shown clinical significance across a few applications but widespread use has been limited by the need for further te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::357d1e618ad1e08aee41a2c279da749e
https://pubmed.ncbi.nlm.nih.gov/21875683
https://pubmed.ncbi.nlm.nih.gov/21875683
Autor:
Jason L J, Dearling, Aiden A, Flynn, Julie, Sutcliffe-Goulden, Ingrid A, Petrie, Robert, Boden, Alan J, Green, Geoffrey M, Boxer, Richard H J, Begent, R Barbara, Pedley
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 45(1)
It has been shown in vitro that the cell uptake of (18)F-FDG, a tracer of glucose metabolism, increases under hypoxia. This is consistent with increased glycolytic metabolism. We have previously shown that in ischemic heart ex vivo the rates of uptak
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a96d094d7f7894901554f608fcbd6c80
https://pubmed.ncbi.nlm.nih.gov/14734681
https://pubmed.ncbi.nlm.nih.gov/14734681
Autor:
Geoffrey M Boxer, Richard H. J. Begent, Aiden A Flynn, R. Barbara Pedley, Alan J. Green, Joanne L. Casey
Publikováno v:
International journal of radiation oncology, biology, physics. 43(1)
Purpose: Radioimmunotherapy of cancer employs an antitumour antibody to carry a radionuclide selectively to deposits of cancer. Conventional dose estimates, based on the Medical Internal Radiation Dose (MIRD) formulation, assume uniform distribution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac5bce93a9840071af309331a85180a
https://pubmed.ncbi.nlm.nih.gov/9989525
https://pubmed.ncbi.nlm.nih.gov/9989525
Autor:
Joanne Porte, Doris M Rassl, Richard P. Marshall, Anthony Habgood, Eunice Oballa, Athol U. Wells, Gauri Saini, Rebecca Braybrooke, Anne-Marie Russell, Hrushikesh Divyateja, Elisabetta A. Renzoni, Toby M. Maher, R. Gisli Jenkins, Anne-Marie Duggan, Pauline T. Lukey, William A. Fahy, Aiden A. Flynn, Helen Parfrey, Richard Hubbard, Philip L. Molyneaux, Juliet Kay Simpson
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disorder with a variable disease trajectory. The aim of this study was to assess potential biomarkers to predict outcomes for people with IPF. METHOD: PROFILE is a large prospect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d060a8ee9e912f7bee9afb0d87e9b0