Výsledky vyhledávání - "Aidas Kriauciunas"

Potent oxindole based human β3 adrenergic receptor agonists

Autor: Droste Christine A, Cynthia Darshini Jesudason, Frank C. Tinsley, Aidas Kriauciunas, Anthony G. Borel, F. Craig Stevens, Mark L. Heiman, Marlene L. Cohen, William E. Bloomquist, Daniel Jon Sall

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 17:6270-6273

The synthesis and biological evaluation of a series of oxindole beta(3) adrenergic receptor agonists is described. A modulation of rat atrial tachycardia was observed with substitution at the 3-position of the oxindole moiety.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149be65c2cec74cff4ef43c8ed998c62
https://doi.org/10.1016/j.bmcl.2007.09.011

Zobrazit plný text záznamu

X-ray absorption spectroscopic studies of the high-spin iron(II) active site of isopenicillin N synthase: evidence for iron-sulfur interaction in the enzyme-substrate complex

Autor: Aidas Kriauciunas, Shengke Wang, Victor J. Chen, Marly K. Eidsness, Robert A. Scott, Charles A. Frolik

Publikováno v: Biochemistry. 31:4596-4601

Isopenicillin N synthase from Cephalosporium acremonium (IPNS; M(r) 38.4K) is an Fe(2+)-requiring enzyme which catalyzes the oxidative conversion of (L-alpha-amino-delta-adipoyl)-L-cysteinyl-D-valine (ACV) to isopenicillin N, with concomitant reducti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70e5f463663e6e56968b2e96212fd783
https://doi.org/10.1021/bi00134a009

Zobrazit plný text záznamu

Thiolate ligation of the active site iron(II) of isopenicillin N synthase derives from substrate rather than endogenous cysteine: spectroscopic studies of site-specific Cys .fwdarw. Ser mutated enzymes

Autor: Eckard Münck, Brian G. Fox, Mark R. Harpel, John D. Lipscomb, Victor J. Chen, Allen M. Orville, Aidas Kriauciunas

Publikováno v: Biochemistry. 31:4602-4612

Isopenicillin N synthase (IPNS) catalyzes double ring closure of the tripeptide (L-alpha-amino-delta-adipoyl)-L-cysteinyl-D-valine (ACV) to form the beta-lactam and thiazolidine rings of penicillin-type antibiotics. Our previous spectroscopic study u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::524c812ce6e1e89355ef49d46467d5ff
https://doi.org/10.1021/bi00134a010

Zobrazit plný text záznamu

NMR studies of the active site of isopenicillin N synthase, a non-heme iron(II) enzyme

Autor: Li-June Ming, Victor J. Chen, Lawrence Que, Aidas Kriauciunas, Charles A. Frolik

Publikováno v: Biochemistry. 30:11653-11659

The active site structure of isopenicillin N synthase (IPNS) has been previously studied by the use of Mossbauer, EPR, electronic absorption, and NMR spectroscopies [Chen, V.J., Frolik, C.A., Orville, A.M., Harpel, M.R., Lipscomb, J.D., Surerus, K.K.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7307072e23a86875358ad38b412e8df7
https://doi.org/10.1021/bi00114a007

Zobrazit plný text záznamu

Reaction of cytochrome c2 with photosynthetic reaction centers from Rhodopseudomonas viridis

Autor: Bill Durham, David B. Knaff, Francis Millett, Anne Willie, Aidas Kriauciunas, Joan E. Long

Publikováno v: Biochemistry. 30:1303-1310

The reactions of Rhodopseudomonas viridis cytochrome c2 and horse cytochrome c with Rps. viridis photosynthetic reaction centers were studied by using both single- and double-flash excitation. Single-flash excitation of the reaction centers resulted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a482b8a1c5ffd05950a41968bf04b2bd
https://doi.org/10.1021/bi00219a021

Zobrazit plný text záznamu

Resonance Raman spectroscopy of cytochrome bc1 complexes from Rhodospirillum rubrum: Initial characterization and reductive titrations

Autor: Aidas Kriauciunas, David B. Knaff, Mark R. Ondrias, David D. Hobbs, Saadettin Güner

Publikováno v: Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1018:47-54

Resonance Raman spectra of bc1 complexes from Rhodospirillum rubrum have been obtained. Various resonance conditions and the stoichiometric redox titration of the complex were used to isolate and identify the contributions of the heme c1 and heme b a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a48330f35b17aaf260d36a31bbbf832
https://doi.org/10.1016/0005-2728(90)90108-g

Zobrazit plný text záznamu

Potent benzimidazolone based human beta(3)-adrenergic receptor agonists

Autor: Don Richard Finley, Mark A. Winter, Daniel Jon Sall, Mark L. Heiman, Marlene L. Cohen, Christopher John Rito, Tania Miles, Anthony J. Shuker, William E. Bloomquist, Anthony G. Borel, Thomas W. Stephens, Michael Gregory Bell, Cynthia Darshini Jesudason, Aidas Kriauciunas, Donald P. Matthews, David Andrew Neel, Frank C. Tinsley

Publikováno v: Bioorganicmedicinal chemistry letters. 16(21)

The synthesis and biological evaluation of a series of benzimidazolone beta(3) adrenergic receptor agonists are described. A trend toward the reduction of rat atrial tachycardia upon increasing steric bulk at the 3-position of the benzimidazolone moi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cafcd2d226d8437bcf2e7a738cbeb735
https://pubmed.ncbi.nlm.nih.gov/16931005

Zobrazit plný text záznamu

Orally bioavailable GSK-3alpha/beta dual inhibitor increases markers of cellular differentiation in vitro and bone mass in vivo

Autor: N.H. Kulkarni, Aidas Kriauciunas, Henry Uhlman Bryant, Tao Wei, Min Liu, David L. Halladay, Masahiko Sato, Yanfei L. Ma, Xioayan Tian, T. John Martin, Charles A. Frolik, Thomas A. Engler, Jude E. Onyia, Qingqiang Zeng

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 21(6)

UNLABELLED: GSK-3, a component of the canonical Wnt signaling pathway, is implicated in regulation of bone mass. The effect of a small molecule GSK-3 inhibitor was evaluated in pre-osteoblasts and in osteopenic rats. GSK-3 inhibitor induced osteoblas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a69e73eef9e2ec8a7fe15b5a2ad64a
https://pubmed.ncbi.nlm.nih.gov/16753022

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání