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pro vyhledávání: '"Aidan Snell"'
Autor:
Amanda K. Riley, Michael Grant, Aidan Snell, Elizabeth Cromwell, Athea Vichas, Sitapriya Moorthi, Callie Rominger, Shrikar P. Modukuri, Anatoly Urisman, Pau Castel, Lixin Wan, Alice H. Berger
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110499- (2024)
Summary: RIT1 is a rare and understudied oncogene in lung cancer. Despite structural similarity to other RAS GTPase proteins such as KRAS, oncogenic RIT1 activity does not appear to be tightly regulated by nucleotide exchange or hydrolysis. Instead,
Externí odkaz:
https://doaj.org/article/80139380a31c425ebc93373b402148ab
Publikováno v:
Cancer Research. 83:2628-2628
Somatic mutations and focal amplifications in the small GTPase RIT1 (Ras-like in all tissues) account for over 13,500 lung cancer diagnoses annually, but treatment options are limited. Of the currently identified mutations, the M90I variant (RIT1M90I