Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Aidan J. Hampson"'
Autor:
Samuel Obeng, Francisco Leon, Avi Patel, Julio D. Zuarth Gonzalez, Lucas Chaves Da Silva, Luis F. Restrepo, Lea R. Gamez-Jimenez, Nicholas P. Ho, Maria P. Guerrero Calvache, Victoria L.C. Pallares, Justin A. Helmes, Sakura K. Shiomitsu, Paul L. Soto, Aidan J. Hampson, Christopher R. McCurdy, Lance R. McMahon, Jenny L. Wilkerson, Takato Hiranita
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 383:182-198
Autor:
Surash Ramanathan, Abhisheak Sharma, Darshan Singh, Lance R. McMahon, Luis F. Restrepo, Takato Hiranita, Avi Patel, Siva Rama Raju Kanumuri, Nelson Jeng Yeou Chear, Francisco León, Grant Zwolinski, Khalil A. Abboud, Christopher R. McCurdy, Aidan J. Hampson
Publikováno v:
Journal of Natural Products. 84:1034-1043
Ten indole and oxindole alkaloids (1-10) were isolated from the freshly collected leaves of Malaysian Mitragyna speciosa (Kratom). The chemical structures of these compounds were established on the basis of extensive 1D and 2D NMR and HRMS data analy
Metabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy
Autor:
Abhisheak Sharma, Christopher R. McCurdy, Carolina Lopera-Londoño, Tamara I. King, Bonnie A. Avery, Shyam H. Kamble, Lance R. McMahon, Francisco León, Aidan J. Hampson, Kanumuri Siva Rama Raju, Erin C. Berthold
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Kratom is widely consumed in the United States for self-treatment of pain and opioid withdrawal symptoms. Mitragynine is the most abundant alkaloid in kratom and is a μ-opioid receptor agonist. 7-Hydroxymitragynine (7-HMG) is a mit
Autor:
Luis F. Restrepo, Erin C. Berthold, Aidan J. Hampson, Avi Patel, Lance R. McMahon, Carolina Lopera-Londoño, Takato Hiranita, Shyam H. Kamble, Samuel Obeng, Abhisheak Sharma, Lea R. Gamez-Jimenez, Francisco León, Clinton E. Canal, Marco Mottinelli, Christopher R. McCurdy, Yiming Chen, Tamara I. King
Publikováno v:
J Med Chem
Kratom alkaloids have mostly been evaluated for their opioid activity but less at other targets that could contribute to their physiological effects. Here, we investigated the in vitro and in vivo activity of kratom alkaloids at serotonin receptors (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749b326c3ebef7e4aed6ae82cdd6614a
https://europepmc.org/articles/PMC9235362/
https://europepmc.org/articles/PMC9235362/
Autor:
Abhisheak Sharma, Elizabeth A. Maxwell, Aidan J. Hampson, Francisco León, Kanumuri Siva Rama Raju, Lance R. McMahon, Tamara I. King, Shyam H. Kamble, Erin C. Berthold, Christopher R. McCurdy
Publikováno v:
Eur J Drug Metab Pharmacokinet
BACKGROUND AND OBJECTIVES: 7-Hydroxymitragynine (7-HMG) is an oxidative metabolite of mitragynine, the most abundant alkaloid in the leaves of Mitragyna speciosa (otherwise known as kratom). While mitragynine is a weak partial μ-opioid receptor (MOR
Autor:
Nelson Jeng-Yeou, Chear, Francisco, León, Abhisheak, Sharma, Siva Rama Raju, Kanumuri, Grant, Zwolinski, Khalil A, Abboud, Darshan, Singh, Luis F, Restrepo, Avi, Patel, Takato, Hiranita, Surash, Ramanathan, Aidan J, Hampson, Lance R, McMahon, Christopher R, McCurdy
Publikováno v:
J Nat Prod
Ten indole and oxindole alkaloids (1–10) were isolated from the freshly collected leaves of Malaysian Mitragyna speciosa (Kratom). The chemical structures of these compounds were established on the basis of extensive 1D and 2D NMR and HRMS data ana
Autor:
Christopher D. Verrico, Jennifer R. Schroeder, Aidan J. Hampson, David H. Epstein, Kayla N. Ellefsen, Luba Yammine, Kenzie L. Preston, Marilyn A. Huestis
Publikováno v:
Clin Pharmacol Ther
Adherence monitoring is a vital component of clinical efficacy trials, as the regularity of medication consumption affects both efficacy and adverse effect profiles. Pill-counts do not confirm consumption, and invasive plasma assessments can only ass
Autor:
Robert Walsh, Aidan J. Hampson
Publikováno v:
Cannabis Use Disorders ISBN: 9783319903644
The first part of this chapter will outline the typical designs used in modern drug discovery programs, starting with initial hit discovery and leading up to the point that FDA permits “first-in-human” testing. It is intended that this outline wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e0a6ddc98556a9a924b8721e91798e1
https://doi.org/10.1007/978-3-319-90365-1_7
https://doi.org/10.1007/978-3-319-90365-1_7
Autor:
Paul A. Nuzzo, Aidan J. Hampson, Michelle R. Lofwall, Phillip Krieter, Sharon L. Walsh, Shanna Babalonis
Publikováno v:
Journal of Clinical Psychopharmacology. 36:324-332
RATIONALE Accurate assessment of medication adherence is critical for determination of medication efficacy in clinical trials, but most current methods have significant limitations. This study tests a subtherapeutic (microdose) of acetazolamide as a
Publikováno v:
The Journal of Clinical Pharmacology. 55:1332-1343
Effective strategies to monitor pharmacotherapy adherence are necessary, and sensitive biological markers are lacking. This study examined a subtherapeutic dose of quinine as a potential adherence tracer. Primary aims included examination of the plas