Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Aidan J, Doherty"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
CAPPs are putative Primase-Polymerases associated with CRISPR-Cas operons. Here, the authors show CAPPs genetic and physical association with Cas1 and Cas2, their capacity to function as DNA-dependent DNA primases and DNA polymerases, and that Cas1-C
Externí odkaz:
https://doaj.org/article/efc9c689cc494105b57df2aab55a9b23
Autor:
Ann Liza Piberger, Akhil Bowry, Richard D. W. Kelly, Alexandra K. Walker, Daniel González-Acosta, Laura J. Bailey, Aidan J. Doherty, Juan Méndez, Joanna R. Morris, Helen E. Bryant, Eva Petermann
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Bulky DNA adducts are important replication-blocking lesions. Here the authors reveal that homologous recombination at bulky adducts in mammalian cells involves post-replicative gap repair in a PrimPol dependent manner.
Externí odkaz:
https://doaj.org/article/0f6811ec82d941be9a6362cf200f312d
Autor:
Nigel C. Brissett, Katerina Zabrady, Przemysław Płociński, Julie Bianchi, Małgorzata Korycka-Machała, Anna Brzostek, Jarosław Dziadek, Aidan J. Doherty
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Mycobacteria Prim-PolC performs short gap synthesis following removal of lesions during excision repair. Here the authors resolve crystal structures of pre- and post-catalytic Prim-PolC complexes bound to gapped DNA substrates to define its mechanism
Externí odkaz:
https://doaj.org/article/346123b81a9e42b09f7fa419672d0f80
Autor:
Mahmoud B. Maina, Laura J. Bailey, Sherin Wagih, Luca Biasetti, Saskia J. Pollack, James P. Quinn, Julian R. Thorpe, Aidan J. Doherty, Louise C. Serpell
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-13 (2018)
Abstract Tau is known for its pathological role in neurodegenerative diseases, including Alzheimer’s disease (AD) and other tauopathies. Tau is found in many subcellular compartments such as the cytosol and the nucleus. Although its normal role in
Externí odkaz:
https://doaj.org/article/a34deb81486543e3bd80a46007061673
Autor:
Przemysław Płociński, Nigel C. Brissett, Julie Bianchi, Anna Brzostek, Małgorzata Korycka-Machała, Andrzej Dziembowski, Jarosław Dziadek, Aidan J. Doherty
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Ligase D is a conserved DNA repair protein complex that repairs double-strand breaks in stationary phase prokaryotes. Here the authors show that orthologous Ligase C has a role in base excision repair during stationary phase.
Externí odkaz:
https://doaj.org/article/a24b3e4c125948e386f4a4cf06019640
Autor:
Thomas A. Guilliam, Nigel C. Brissett, Aaron Ehlinger, Benjamin A. Keen, Peter Kolesar, Elaine M. Taylor, Laura J. Bailey, Howard D. Lindsay, Walter J. Chazin, Aidan J. Doherty
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
PrimPol is a multifunctional replicative enzyme that can bypass DNA damage, as well as reprime replication restart. Here, the authors have elucidated how PrimPol is recruited to stalled replication forks via specific interactions with RPA, which stim
Externí odkaz:
https://doaj.org/article/6c3b35c0421a4ab2b8722df6acbdcac6
Autor:
Masataka Tsuda, Saki Ogawa, Masato Ooka, Kaori Kobayashi, Kouji Hirota, Mitsuo Wakasugi, Tsukasa Matsunaga, Tetsushi Sakuma, Takashi Yamamoto, Shunsuke Chikuma, Hiroyuki Sasanuma, Michelle Debatisse, Aidan J Doherty, Robert P Fuchs, Shunichi Takeda
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0213383 (2019)
Replicative DNA polymerases are frequently stalled at damaged template strands. Stalled replication forks are restored by the DNA damage tolerance (DDT) pathways, error-prone translesion DNA synthesis (TLS) to cope with excessive DNA damage, and erro
Externí odkaz:
https://doaj.org/article/19f99db9044847b2a3d180b42b4ea026
Autor:
Arthur W. H. Li, Katerina Zabrady, Lewis J. Bainbridge, Matej Zabrady, Sehr Naseem-Khan, Madison B. Berger, Peter Kolesar, G. Andrés Cisneros, Aidan J. Doherty
Publikováno v:
Nature
During the initiation of DNA replication, oligonucleotide primers are synthesized de novo by primases and are subsequently extended by replicative polymerases to complete genome duplication. The primase-polymerase (Prim-Pol) superfamily is a diverse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305f2d6f7b0c71293c9847b071860c16
https://doi.org/10.1038/s41586-022-04695-0
https://doi.org/10.1038/s41586-022-04695-0
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Alzheimer’s disease (AD) is the most common form of dementia and is distinguished from other dementias by observation of extracellular Amyloid-β (Aβ) plaques and intracellular neurofibrillary tangles, comprised of fibrils of Aβ and tau protein,
Externí odkaz:
https://doaj.org/article/900f80d41ee14dfd87e27493d2b44a8a
Publikováno v:
Cell Reports, Vol 9, Iss 6, Pp 2011-2017 (2014)
Eukaryotic cells use two principal mechanisms for repairing DNA double-strand breaks (DSBs): homologous recombination (HR) and nonhomologous end-joining (NHEJ). DSB repair pathway choice is strongly regulated during the cell cycle. Cyclin-dependent k
Externí odkaz:
https://doaj.org/article/71a896fa1bc149c5bdce1a7ec7fda870