Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Aidan I Brown"'
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 8, p e1010413 (2022)
For many nuclear-encoded mitochondrial genes, mRNA localizes to the mitochondrial surface co-translationally, aided by the association of a mitochondrial targeting sequence (MTS) on the nascent peptide with the mitochondrial import complex. For a sub
Externí odkaz:
https://doaj.org/article/9e486aa56ee3495babbb461830ebe753
Autor:
Aidan I Brown, Elena F Koslover
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 2, p e1008654 (2021)
Newly-translated glycoproteins in the endoplasmic reticulum (ER) often undergo cycles of chaperone binding and release in order to assist in folding. Quality control is required to distinguish between proteins that have completed native folding, thos
Externí odkaz:
https://doaj.org/article/6a105b7d873945c5a726ace8866d4122
Autor:
Zhijie Chen, Ronen Gabizon, Aidan I Brown, Antony Lee, Aixin Song, César Díaz-Celis, Craig D Kaplan, Elena F Koslover, Tingting Yao, Carlos Bustamante
Publikováno v:
eLife, Vol 8 (2019)
Nucleosomes represent mechanical and energetic barriers that RNA Polymerase II (Pol II) must overcome during transcription. A high-resolution description of the barrier topography, its modulation by epigenetic modifications, and their effects on Pol
Externí odkaz:
https://doaj.org/article/572da9e83d4c49dcb15a19912c6b95e2
Autor:
Abdul Haseeb Khan, Xuefang Gu, Rutvik J. Patel, Prabha Chuphal, Matheus P. Viana, Aidan I. Brown, Brian M. Zid, Tatsuhisa Tsuboi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract A decline in mitochondrial function is a hallmark of aging and neurodegenerative diseases. It has been proposed that changes in mitochondrial morphology, including fragmentation of the tubular mitochondrial network, can lead to mitochondrial
Externí odkaz:
https://doaj.org/article/74f0995a4c9f4af9a5b2f6c2046a9aa1
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 1, p e1003426 (2014)
Peroxisomes are membrane-bound organelles within eukaryotic cells that post-translationally import folded proteins into their matrix. Matrix protein import requires a shuttle receptor protein, usually PEX5, that cycles through docking with the peroxi
Externí odkaz:
https://doaj.org/article/aad5704a91e140ebb7d04804fd3202f8
Autor:
Michael G. Sugiyama, Aidan I. Brown, Jesus Vega-Lugo, Jazlyn P. Borges, Andrew M. Scott, Khuloud Jaqaman, Gregory D. Fairn, Costin N. Antonescu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The epidermal growth factor receptor (EGFR) is a central regulator of cell physiology. EGFR is activated by ligand binding, triggering receptor dimerization, activation of kinase activity, and intracellular signaling. EGFR is transiently con
Externí odkaz:
https://doaj.org/article/a76bca4ec1bb40f1bbe42379e8c8888d
The epidermal growth factor receptor (EGFR) is a central regulator of cell physiology that is stimulated by multiple distinct ligands. Although ligands bind to EGFR while the receptor is exposed on the plasma membrane, EGFR incorporation into endosom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dd4e041061d47d780fb2239428ebab3
https://doi.org/10.1101/2023.05.09.539827
https://doi.org/10.1101/2023.05.09.539827
Autor:
Michael G. Sugiyama, Aidan I. Brown, Jesus Vega-Lugo, Andrew M. Scott, Khuloud Jaqaman, Gregory D. Fairn, Costin N. Antonescu
The epidermal growth factor receptor (EGFR) is a central regulator of cell physiology. EGFR is activated by ligand binding, triggering receptor dimerization, activation of kinase activity, and intracellular signaling. EGFR is transiently confined wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8a4c28baec0cf507dbb66aed378eb83
https://doi.org/10.1101/2022.03.04.483015
https://doi.org/10.1101/2022.03.04.483015
Autor:
Aidan I. Brown, Laura M. Westrate, Elena F. Koslover, Saurabh S. Mogre, Zubenelgenubi C. Scott
Publikováno v:
The European physical journal. E, Soft matter, vol 44, iss 6
The European Physical Journal. E, Soft Matter
The European Physical Journal. E, Soft Matter
Abstract Several organelles in eukaryotic cells, including mitochondria and the endoplasmic reticulum, form interconnected tubule networks extending throughout the cell. These tubular networks host many biochemical pathways that rely on proteins diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b996ca22a9e94c7e9ebb078646296e3
https://escholarship.org/uc/item/72b6c68s
https://escholarship.org/uc/item/72b6c68s