Delayed low-dose oral administration of 4'-fluorouridine inhibits pathogenic arenaviruses in animal models of lethal disease.

Autor: Welch SR; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA., Spengler JR; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA., Westover JB; Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322, USA., Bailey KW; Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322, USA., Davies KA; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.; Zoonotic and Emerging Disease Research Unit, National Bio and Agro-Defense Facility, US Department of Agriculture, Manhattan, KS 66506, USA., Aida-Ficken V; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.; Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA., Bluemling GR; Emory Institute for Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA., Boardman KM; Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322, USA., Wasson SR; Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322, USA., Mao S; Emory Institute for Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA., Kuiper DL; Emory Institute for Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA., Hager MW; Emory Institute for Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA., Saindane MT; Emory Institute for Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA., Andrews MK; Emory Institute for Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA., Krueger RE; Emory Institute for Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA., Sticher ZM; Emory Institute for Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA., Jung KH; Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322, USA., Chatterjee P; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA., Shrivastava-Ranjan P; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA., Lo MK; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA., Coleman-McCray JD; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA., Sorvillo TE; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA., Genzer SC; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA., Scholte FEM; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA., Kelly JA; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA., Jenks MH; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA., McMullan LK; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA., Albariño CG; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA., Montgomery JM; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA., Painter GR; Emory Institute for Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA., Natchus MG; Emory Institute for Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA., Kolykhalov AA; Emory Institute for Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA., Gowen BB; Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322, USA., Spiropoulou CF; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA., Flint M; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Nov 20; Vol. 16 (774), pp. eado7034. Date of Electronic Publication: 2024 Nov 20.