Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Aida Rahmani Mashhour"'
Autor:
Patrick Y. A. Reinke, Robin Schubert, Dominik Oberthür, Marina Galchenkova, Aida Rahmani Mashhour, Sebastian Günther, Anaïs Chretien, Adam Round, Brandon Charles Seychell, Brenna Norton-Baker, Chan Kim, Christina Schmidt, Faisal H. M. Koua, Alexandra Tolstikova, Wiebke Ewert, Gisel Esperanza Peña Murillo, Grant Mills, Henry Kirkwood, Hévila Brognaro, Huijong Han, Jayanath Koliyadu, Joachim Schulz, Johan Bielecki, Julia Lieske, Julia Maracke, Juraj Knoska, Kristina Lorenzen, Lea Brings, Marcin Sikorski, Marco Kloos, Mohammad Vakili, Patrik Vagovic, Philipp Middendorf, Raphael de Wijn, Richard Bean, Romain Letrun, Seonghyun Han, Sven Falke, Tian Geng, Tokushi Sato, Vasundara Srinivasan, Yoonhee Kim, Oleksandr M. Yefanov, Luca Gelisio, Tobias Beck, Andrew S. Doré, Adrian P. Mancuso, Christian Betzel, Saša Bajt, Lars Redecke, Henry N. Chapman, Alke Meents, Dušan Turk, Winfried Hinrichs, Thomas J. Lane
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The main protease (Mpro) of SARS-CoV-2 is critical for viral function and a key drug target. Mpro is only active when reduced; turnover ceases upon oxidation but is restored by re-reduction. This suggests the system has evolved to survive pe
Externí odkaz:
https://doaj.org/article/7a737b71ae764265a7f11a3df650ea0b
Autor:
Patrick Y. A. Reinke, Edmarcia Elisa de Souza, Sebastian Günther, Sven Falke, Julia Lieske, Wiebke Ewert, Jure Loboda, Alexander Herrmann, Aida Rahmani Mashhour, Katarina Karničar, Aleksandra Usenik, Nataša Lindič, Andreja Sekirnik, Viviane Fongaro Botosso, Gláucia Maria Machado Santelli, Josana Kapronezai, Marcelo Valdemir de Araújo, Taiana Tainá Silva-Pereira, Antônio Francisco de Souza Filho, Mariana Silva Tavares, Lizdany Flórez-Álvarez, Danielle Bruna Leal de Oliveira, Edison Luiz Durigon, Paula Roberta Giaretta, Marcos Bryan Heinemann, Maurice Hauser, Brandon Seychell, Hendrik Böhler, Wioletta Rut, Marcin Drag, Tobias Beck, Russell Cox, Henry N. Chapman, Christian Betzel, Wolfgang Brehm, Winfried Hinrichs, Gregor Ebert, Sharissa L. Latham, Ana Marcia de Sá Guimarães, Dusan Turk, Carsten Wrenger, Alke Meents
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Several drug screening campaigns identified Calpeptin as a drug candidate against SARS-CoV-2. Initially reported to target the viral main protease (Mpro), its moderate activity in Mpro inhibition assays hints at a second target. Indeed, we s
Externí odkaz:
https://doaj.org/article/959ee7d783844cc0965882267049dc4f
Autor:
Vasundara Srinivasan, Hévila Brognaro, Prince R. Prabhu, Edmarcia Elisa de Souza, Sebastian Günther, Patrick Y. A. Reinke, Thomas J. Lane, Helen Ginn, Huijong Han, Wiebke Ewert, Janina Sprenger, Faisal H. M. Koua, Sven Falke, Nadine Werner, Hina Andaleeb, Najeeb Ullah, Bruno Alves Franca, Mengying Wang, Angélica Luana C. Barra, Markus Perbandt, Martin Schwinzer, Christina Schmidt, Lea Brings, Kristina Lorenzen, Robin Schubert, Rafael Rahal Guaragna Machado, Erika Donizette Candido, Danielle Bruna Leal Oliveira, Edison Luiz Durigon, Stephan Niebling, Angelica Struve Garcia, Oleksandr Yefanov, Julia Lieske, Luca Gelisio, Martin Domaracky, Philipp Middendorf, Michael Groessler, Fabian Trost, Marina Galchenkova, Aida Rahmani Mashhour, Sofiane Saouane, Johanna Hakanpää, Markus Wolf, Maria Garcia Alai, Dusan Turk, Arwen R. Pearson, Henry N. Chapman, Winfried Hinrichs, Carsten Wrenger, Alke Meents, Christian Betzel
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Three natural phenolic compounds are found to bind to an allosteric site in SARS-CoV-2 papain-like protease and exhibit antiviral activity in vitro, showing potential as starting scaffolds for drug design.
Externí odkaz:
https://doaj.org/article/94a6b8437953446b80663a578e6c235a
Autor:
Marina Galchenkova, Aida Rahmani Mashhour, Patrick Y. A. Reinke, Sebastian Günther, Jan Meyer, Henry N. Chapman, Oleksandr M. Yefanov
Publikováno v:
Crystals, Vol 13, Iss 8, p 1225 (2023)
Serial crystallography is a rapidly developing method for the determination of the structure of biomolecules at room temperature at near-atomic resolution from an ensemble of small crystals. Numerous advances in detectors, data analysis pipelines, sa
Externí odkaz:
https://doaj.org/article/2b30a77376ea4aebb957d461e536d4df
Autor:
Patrick Reinke, Edmarcia de Souza, Sebastian Günther, Sven Falke, Julia Lieske, Wiebke Ewert, Jure Loboda, Alexander Herrmann, Aida Rahmani Mashhour, Katarina Karnicar, Aleksandra Usenik, Natasa Lindic, Andreja Sekirnik, Viviane Botosso, Gláucia Machado Santelli, Josana Kapronezai, Marcelo de Araújo, Taiana Silva-Pereira, Antonio Souza Filho, Mariana Tavares, Lizdany Flórez-Álvarez, Danielle Oliveira, Edison Durigon, Paula Giaretta, Marcos Heinemann, Maurice Hauser, Brandon Seychell, Hendrik Böhler, Wioletta Rut, Marcin Drag, Tobias Beck, Russell Cox, Henry Chapman, Christian Betzel, Wolfgang Brehm, Winfried Hinrichs, Gregor Ebert, Sharissa Latham, Ana Marcia Guimarães, Dušan Turk, Carsten Wrenger, Alke Meents
Several drug screening campaigns identified Calpeptin as a drug candidate against SARS-CoV-2. Initially reported to target the viral main protease (Mpro), its moderate activity in Mpro inhibition assays hints at a second target. Indeed, we show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a39214aa65c5a9ef54c73b10a0e72cbe
https://doi.org/10.21203/rs.3.rs-2450926/v1
https://doi.org/10.21203/rs.3.rs-2450926/v1
Autor:
M. Schwinzer, Faisal Hammad Mekky Koua, Ashwin Chari, J. Lieske, Maria Garcia-Alai, Gleb Bourenkov, Russell J. Cox, Salah Awel, W. Ewert, Dušan Turk, Luca Gelisio, N. Werner, Hévila Brognaro, J. Pletzer-Zelgert, Juraj Knoska, Arwen R. Pearson, D. Melo, Matthias Rarey, Ilona Dunkel, Boris Krichel, Y. Gevorkov, A. Tolstikova, David von Stetten, Eike C. Schulz, Andrea Zaliani, Winfried Hinrichs, F. Trost, Helen M. Ginn, Xinyuanyuan Sun, Stephan Niebling, Holger Fleckenstein, Aleksandra Usenik, J. Wollenhaupt, Robin Schubert, Stephan Günther, Kristina Lorenzen, J. Boger, P. Reinke, Diana C. F. Monteiro, Bruno Alves Franca, Isabel Bento, Manfred S. Weiss, Ariana Peck, Dominik Oberthuer, Pedram Mehrabi, Pontus Fischer, Sebastian Günther, Jure Loboda, P. Lourdu Xavier, C. Schmidt, Christian Betzel, Huijong Han, N. Ullah, Philip Gribbon, Aida Rahmani Mashhour, Charlotte Uetrecht, Guillaume Pompidor, Christiane Ehrt, Christian G. Feiler, Saravanan Panneerselvam, Bernhard Ellinger, Christian M. Günther, Thomas J. Lane, Linlin Zhang, S. Meier, Tobias Beck, Henry N. Chapman, M. Domaracky, Sven Falke, Katarina Karničar, Markus Wolf, Cromarte Rogers, S. Saouane, Ivars Karpics, Rolf Hilgenfeld, Gisel E. Peña-Murillo, Vasundara Srinivasan, Alke Meents, Miriam Barthelmess, M. Galchenkova, B. Seychell, Beatriz Escudero-Pérez, Thomas A. White, Janine-Denise Kopicki, Joanna J. Zaitseva-Doyle, W. Brehm, M. Groessler, Brenna Norton-Baker, Frank Schlünzen, Chufeng Li, Henning Tidow, Maria Kuzikov, Andrea R. Beccari, Johanna Hakanpää, Henry Gieseler, Yaiza Fernández-García, Oleksandr Yefanov, Thomas R. Schneider, Anna Hänle, Jan Meyer, H. Andaleeb, V. Hennicke
Publikováno v:
Science (New York, N.y.)
Science 372 (6542): 642-646 (2021-05-07)
Science
Science / Science now 372(6542), 642-646 (2021). doi:10.1126/science.abf7945
Science 372 (6542): 642-646 (2021-05-07)
Science
Science / Science now 372(6542), 642-646 (2021). doi:10.1126/science.abf7945
A large-scale screen to target SARS-CoV-2 The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome is initially expressed as two large polyproteins. Its main protease, Mpro, is essential to yield functional viral proteins, making it a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7f9ac410aabd144f9e9014ed83aff5
https://resolver.caltech.edu/CaltechAUTHORS:20201113-100151878
https://resolver.caltech.edu/CaltechAUTHORS:20201113-100151878
Autor:
Henry Gieseler, David von Stetten, A. Tolstikova, Luca Gelisio, Yaiza Fernández-García, Guillaume Pompidor, Saravanan Panneerselvam, Cromarte Rogers, M. Galchenkova, Juraj Knoska, B. Seychell, Gleb Bourenkov, Ariana Peck, Stephan Niebling, D. Melo, Hévila Brognaro, Russell J. Cox, Rolf Hilgenfeld, W. Brehm, J. Lieske, Matthias Rarey, Aleksandra Usenik, Tobias Beck, Oleksandr Yefanov, Henry N. Chapman, Isabel Bento, C. Schmidt, M. Groessler, Ashwin Chari, Sven Falke, Katarina Karničar, Thomas J. Lane, Beatriz Escudero-Pérez, J. Boger, Bernhard Ellinger, Christian M. Günther, Christiane Ehrt, Markus Wolf, Jure Loboda, Thomas R. Schneider, Andrea Zaliani, P. Lourdu Xavier, Eike C. Schulz, J. Wollenhaupt, Brenna Norton-Baker, Ivars Karpics, Salah Awel, Aida Rahmani Mashhour, Frank Schlünzen, Chufeng Li, Henning Tidow, Robin Schubert, Y. Gevorkov, H. Andaleeb, P. Reinke, Stephan Günther, Christian G. Feiler, Manfred S. Weiss, Jo J. Zaitsev-Doyle, N. Ullah, M. Domaracky, Pontus Fischer, Linlin Zhang, Maria Kuzikov, V. Hennicke, W. Ewert, Faisal Hammad Mekky Koua, P. Gribbon, Xinyuanyuan Sun, Dominik Oberthuer, S. Meier, J. Pletzer-Zelgert, Kristina Lorenzen, Christian Betzel, M. Schwinzer, Bruno Alves Franca, Charlotte Uetrecht, S. Saouane, Pedram Mehrabi, Helen M. Ginn, Andrea R. Beccari, Johanna Hakanpää, Diana C. F. Monteiro, Ilona Dunkel, Janine-Denise Kopicki, Anna Hänle, Miriam Barthelmess, Jan Meyer, Dušan Turk, N. Werner, Thomas A. White, Boris Krichel, Winfried Hinrichs, F. Trost, Sebastian Günther, Filip Guicking, Vasundara Srinivasan, Alke Meents, Gisel E. Peña Murillo, Maria Marta Garcia Alai, Huijong Han, Arwen R. Pearson, Holger Fleckenstein
The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating tremendous health problems and economical challenges for mankind. To date, no effective drug is available to directly treat the disease and prevent virus spreading. In a search for a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78d640669dec95efad943e6c0a02e329
https://doi.org/10.1101/2020.11.12.378422
https://doi.org/10.1101/2020.11.12.378422
Autor:
Yaiza Fernández-García, Dominik Oberthuer, Christian Betzel, Tobias Beck, Markus Wolf, Kristina Lorenzen, M. Domaracky, Bruno Alves Franca, Jo J. Zaitsev-Doyle, Dušan Turk, Hévila Brognaro, Arwen R. Pearson, Henry N. Chapman, Jan Meyer, Robin Schubert, Stephan Günther, M. Galchenkova, Eike C. Schulz, B. Seychell, Manfred S. Weiss, H. Andaleeb, Aida Rahmani Mashhour, Y. Gevorkov, Sven Falke, Pedram Mehrabi, V. Hennicke, Beatriz Escudero-Pérez, Xinyuanyuan Sun, Juraj Knoska, Linlin Zhang, S. Meier, J. Pletzer-Zelgert, Holger Fleckenstein, N. Ullah, Rolf Hilgenfeld, Oleksandr Yefanov, Cromarte Rogers, Henry Gieseler, Thomas J. Lane, Ariana Peck, Alke Meents, C. Schmidt, J. Wollenhaupt, J. Lieske, Huijong Han, Helen M. Ginn, Bernhard Ellinger, Diana C. F. Monteiro, Christiane Ehrt, Pontus Fischer, Illona Dunkel, F. Trost, Luca Gelisio, Sebastian Günther, A. Tolstikova, Faisal Hammad Mekky Koua, Gisel Esperanza, D. Melo, Christian G. Feiler, Matthias Rarey, Andrea Zaliani, P. Reinke, M. Schwinzer, Russell J. Cox, Heshmat Noei, Salah Awel, N. Werner, Boris Krichel, Charlotte Uetrecht, Ashwin Chari, P. Gribbon, P. Lourdu Xavier, W. Brehm, S. Saouane, M. Groessler, Brenna Norton-Baker, Frank Schlünzen, Chufeng Li, Henning Tidow, Maria Kuzikov, Johanna Hakanpää, Miriam Barthelmess, Thomas A. White, Filip Guicking
Publikováno v:
Zenodo (2020). doi:10.1101/2020.05.02.043554
Here we present the crystal structure of SARS-CoV-2 main protease (Mpro) covalently bound to 2-methyl-1-tetralone. This complex was obtained by co-crystallization of Mpro with HEAT (2-(((4-hydroxyphenethyl)amino)methyl)-3,4-dihydronaphthalen-1(2H)-on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad748548ca306603280bbd7e9f68a2fe
https://hdl.handle.net/21.11116/0000-0006-61B1-421.11116/0000-0006-61B3-2
https://hdl.handle.net/21.11116/0000-0006-61B1-421.11116/0000-0006-61B3-2
Autor:
Christou, Nina-Eleni1, Apostolopoulou, Virginia2, Melo, Diogo V. M.3, Ruppert, Matthias4,5, Fadini, Alisia6,7, Henkel, Alessandra1, Sprenger, Janina1, Oberthuer, Dominik1, Günther, Sebastian1, Pateras, Anastasios1, Mashhour, Aida Rahmani1, Yefanov, Oleksandr M.1, Galchenkova, Marina1, Reinke, Patrick Y. A.1, Kremling, Viviane1, Scheer, T. Emilie S.1, Lange, Esther R.1, Middendorf, Philipp1, Schubert, Robin3, Zitter, Elke De8
Publikováno v:
Science. 12/1/2023, Vol. 382 Issue 6674, p1015-1020. 6p. 5 Color Photographs.
Autor:
Reinke, Patrick Y. A.1 (AUTHOR), de Souza, Edmarcia Elisa2 (AUTHOR), Günther, Sebastian1 (AUTHOR), Falke, Sven1 (AUTHOR), Lieske, Julia1 (AUTHOR), Ewert, Wiebke1 (AUTHOR), Loboda, Jure3,4 (AUTHOR), Herrmann, Alexander5 (AUTHOR), Rahmani Mashhour, Aida1 (AUTHOR), Karničar, Katarina3,6 (AUTHOR), Usenik, Aleksandra3,6 (AUTHOR), Lindič, Nataša3 (AUTHOR), Sekirnik, Andreja3 (AUTHOR), Botosso, Viviane Fongaro7 (AUTHOR), Santelli, Gláucia Maria Machado8 (AUTHOR), Kapronezai, Josana7 (AUTHOR), de Araújo, Marcelo Valdemir7,9 (AUTHOR), Silva-Pereira, Taiana Tainá9,10 (AUTHOR), Filho, Antônio Francisco de Souza9 (AUTHOR), Tavares, Mariana Silva9 (AUTHOR)
Publikováno v:
Communications Biology. 10/18/2023, Vol. 6 Issue 1, p1-13. 13p.