Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Aida Oliván-Viguera"'
Publikováno v:
Sensors, Vol 23, Iss 23, p 9454 (2023)
Cardiotoxicity, characterized by adverse impacts on normal heart function due to drug exposure, is a significant concern due to the potentially serious side effects associated with various pharmaceuticals. It is essential to detect the cardiotoxicity
Externí odkaz:
https://doaj.org/article/8fc9e4369a6b43918ad429109938f065
Autor:
Laura García-Mendívil, María Pérez-Zabalza, Konstantinos Mountris, Sam Duwé, Nick Smisdom, Marta Pérez, Lluís Luján, Esther Wolfs, Ronald B. Driesen, José María Vallejo-Gil, Pedro Carlos Fresneda-Roldán, Javier Fañanás-Mastral, Manuel Vázquez-Sancho, Marta Matamala-Adell, Juan Fernando Sorribas-Berjón, Javier André Bellido-Morales, Francisco Javier Mancebón-Sierra, Alexánder Sebastián Vaca-Núñez, Carlos Ballester-Cuenca, Aida Oliván-Viguera, Emiliano Diez, Laura Ordovás, Esther Pueyo
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103822- (2022)
Summary: Age-related fibrosis in the left ventricle (LV) has been mainly studied in animals by assessing collagen content. Using second-harmonic generation microscopy and image processing, we evaluated amount, aggregation and spatial distribution of
Externí odkaz:
https://doaj.org/article/9e20c6751f95457bbf486b1eec24443c
Autor:
Javier Lozano-Gerona, Aida Oliván-Viguera, Pablo Delgado-Wicke, Vikrant Singh, Brandon M Brown, Elena Tapia-Casellas, Esther Pueyo, Marta Sofía Valero, Ángel-Luis Garcia-Otín, Pilar Giraldo, Edgar Abarca-Lachen, Joaquín C Surra, Jesús Osada, Kirk L Hamilton, Siba P Raychaudhuri, Miguel Marigil, Ángeles Juarranz, Heike Wulff, Hiroto Miura, Yolanda Gilaberte, Ralf Köhler
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0222619 (2020)
Ion channels have recently attracted attention as potential mediators of skin disease. Here, we explored the consequences of genetically encoded induction of the cell volume-regulating Ca2+-activated KCa3.1 channel (Kcnn4) for murine epidermal homeos
Externí odkaz:
https://doaj.org/article/007ac73a43e4438e83b0321c8c8bf679
Autor:
Ulf Simonsen, Anna K. Winther, Aida Oliván-Viguera, Simon Comerma-Steffensen, Ralf Köhler, Toke Bek
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 8, p 2032 (2019)
We investigated whether the substrate for nitric oxide (NO) production, extracellular l-arginine, contributes to relaxations induced by activating small (SKCa) conductance Ca2+-activated potassium channels. In endothelial cells, acetylcholine increas
Externí odkaz:
https://doaj.org/article/f65ac9524bab4c089ab47740994984bc
Autor:
Marta Sofía Valero, Mariano Ramón-Gimenez, Javier Lozano-Gerona, Pablo Delgado-Wicke, Pilar Calmarza, Aida Oliván-Viguera, Víctor López, Ángel-Luis Garcia-Otín, Salvador Valero, Esther Pueyo, Kirk L. Hamilton, Hiroto Miura, Ralf Köhler
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 5, p 1193 (2019)
Abstract: The epithelial intermediate-conductance calcium/calmodulin-regulated KCa3.1 channel is considered to be a regulator of intestine function by controlling chloride secretion and water/salt balance. Yet, little is known about the functional im
Externí odkaz:
https://doaj.org/article/077eebc4fcc9448ea0bb40fda0d3ea27
Autor:
Maj Rabjerg, Aida Oliván-Viguera, Lars Koch Hansen, Line Jensen, Linda Sevelsted-Møller, Steen Walter, Boye L Jensen, Niels Marcussen, Ralf Köhler
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0122992 (2015)
Ca2+-activated K+ channels have been implicated in cancer cell growth, metastasis, and tumor angiogenesis. Here we hypothesized that high mRNA and protein expression of the intermediate-conductance Ca2+-activated K+ channel, KCa3.1, is a molecular ma
Externí odkaz:
https://doaj.org/article/b9ac3e59408f4faa92dbf27206edcfdb
Autor:
Ana Isabel Fernández-Mariño, Pilar Cidad, Delia Zafra, Laura Nocito, Jorge Domínguez, Aida Oliván-Viguera, Ralf Köhler, José R López-López, María Teresa Pérez-García, Miguel Ángel Valverde, Joan J Guinovart, José M Fernández-Fernández
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0118148 (2015)
Despite the substantial knowledge on the antidiabetic, antiobesity and antihypertensive actions of tungstate, information on its primary target/s is scarce. Tungstate activates both the ERK1/2 pathway and the vascular voltage- and Ca2+-dependent larg
Externí odkaz:
https://doaj.org/article/25b697aef0f54fd5af54d19183c72a86
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112081 (2014)
Cytochrome P450- and ω-hydrolase products (epoxyeicosatrienoic acids (EETs), hydroxyeicosatetraeonic acid (20-HETE)), natural omega-3 fatty acids (ω3), and pentacyclic triterpenes have been proposed to contribute to a wide range of vaso-protective
Externí odkaz:
https://doaj.org/article/dbeaad14abfd49da994535929c647dff
Autor:
Aida Oliván-Viguera, Marta Sofía Valero, María Divina Murillo, Heike Wulff, Angel-Luis García-Otín, José-Miguel Arbonés-Mainar, Ralf Köhler
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58614 (2013)
KCa3.1 channels are calcium/calmodulin-regulated voltage-independent K(+) channels that produce membrane hyperpolarization and shape Ca(2+)-signaling and thereby physiological functions in epithelia, blood vessels, and white and red blood cells. Up-r
Externí odkaz:
https://doaj.org/article/b254920c5f294d459acec2370a58b5c3
Autor:
Kate Lykke Lambertsen, Jan Bert Gramsbergen, Mithula Sivasaravanaparan, Nicholas Ditzel, Linda Maria Sevelsted-Møller, Aida Oliván-Viguera, Maj Rabjerg, Heike Wulff, Ralf Köhler
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47744 (2012)
The calmodulin/calcium-activated K(+) channel KCa3.1 is expressed in red and white blood cells, epithelia and endothelia, and possibly central and peripheral neurons. However, our knowledge about its contribution to neurological functions and behavio
Externí odkaz:
https://doaj.org/article/0fad14b82d2e47bda172ff3266e8e9bb