Mechanical stimulation of induced pluripotent stem cell derived cardiac fibroblasts

Autor: Fjodor T. Bekedam, Rowan Smal, Marisa C. Smit, Jurjan Aman, Anton Vonk-Noordegraaf, Harm Jan Bogaard, Marie José Goumans, Frances S. De Man, Aida Llucià-Valldeperas

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)

Abstract Cardiac fibrosis contributes to the development of heart failure, and is the response of cardiac fibroblasts (CFs) to pressure or volume overload. Limiting factors in CFs research are the poor availability of human cells and the tendency of

Externí odkaz: https://doaj.org/article/585c620b0a47474eb2356249f8333fef

The thromboxane receptor antagonist NTP42 promotes beneficial adaptation and preserves cardiac function in experimental models of right heart overload

Autor: Eamon P. Mulvaney, Fabiana Renzo, Rui Adão, Emilie Dupre, Lucia Bialesova, Viviana Salvatore, Helen M. Reid, Glória Conceição, Julien Grynblat, Aida Llucià-Valldeperas, Jean-Baptiste Michel, Carmen Brás-Silva, Charles E. Laurent, Luke S. Howard, David Montani, Marc Humbert, Anton Vonk Noordegraaf, Frédéric Perros, Pedro Mendes-Ferreira, B. Therese Kinsella

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 9 (2022)

BackgroundPulmonary arterial hypertension (PAH) is a progressive disease characterized by increased pulmonary artery pressure leading to right ventricular (RV) failure. While current PAH therapies improve patient outlook, they show limited benefit in

Externí odkaz: https://doaj.org/article/61ac0e73143f434fb6aee88b5fe3d60f

A Cell-Enriched Engineered Myocardial Graft Limits Infarct Size and Improves Cardiac Function

Autor: Isaac Perea-Gil, MS, Cristina Prat-Vidal, PhD, Carolina Gálvez-Montón, DVM, PhD, Santiago Roura, PhD, Aida Llucià-Valldeperas, PhD, Carolina Soler-Botija, PhD, Oriol Iborra-Egea, MS, Idoia Díaz-Güemes, DVM, PhD, Verónica Crisóstomo, DVM, PhD, Francisco M. Sánchez-Margallo, DVM, PhD, Antoni Bayes-Genis, MD, PhD

Publikováno v: JACC: Basic to Translational Science, Vol 1, Iss 5, Pp 360-372 (2016)

Myocardial infarction (MI) remains a dreadful disease around the world, causing irreversible sequelae that shorten life expectancy and reduce quality of life despite current treatment. Here, the authors engineered a cell-enriched myocardial graft, co

Externí odkaz: https://doaj.org/article/bac55280760c45a7895fad68a7452975

Interplay of sex hormones and long-term right ventricular adaptation in a Dutch PAH-cohort

Autor: Joanne A. Groeneveldt, Christophe Guignabert, Rowan Smal, Samara M.A. Jansen, Berend E. Westerhof, Peter Dorfmüller, Frances S. de Man, Frank P. T. Oosterveer, Anne Keogh, Harm Jan Bogaard, Annemieke C. Heijboer, Marie-José Goumans, Lilian J. Meijboom, Anton Vonk Noordegraaf, M. Louis Handoko, Hans W.M. Niessen, Olaf Mercier, A. Josien Smits, Cathelijne Emma van der Bruggen, Jessie Van Wezenbeek, Marc Humbert, Joost W. van Leeuwen, J. Tim Marcus, Aida Llucià-Valldeperas, Cris dos Remedios

Publikováno v: Journal of Heart and Lung Transplantation, 41(4), 445-457. Elsevier USA
Journal of heart and lung transplantation, 41(4), 445-457. Elsevier USA
The Journal of Heart and Lung Transplantation
The Journal of Heart and Lung Transplantation, 2021, Online ahead of print. ⟨10.1016/j.healun.2021.11.004⟩
Journal of Heart and Lung Transplantation. Elsevier USA
van Wezenbeek, J, Groeneveldt, JA, Llucià Valldeperas, A, van der Bruggen, CEE, Jansen, SMA, Smits, AJ, Smal, R, van Leeuwen, J W, dos Remedios, C, Keogh, A, Humbert, M, Dorfmuller, P, Mercier, O, Guignabert, C, Niessen, JWM, Handoko, ML, Marcus, JT, Meijboom, LJ, Oosterveer, F P T, Westerhof, BE, Heijboer, AC, Bogaard, HJ, Vonk-Noordegraaf, A, Goumans, M-J T H & de Man, FS 2021, ' Interplay of sex hormones and long-term right ventricular adaptation in a Dutch PAH-cohort ', Journal of Heart and Lung Transplantation . < https://www.jhltonline.org/article/S1053-2498(21)02581-X/fulltext >
van Wezenbeek, J, Groeneveldt, J A, Llucià-Valldeperas, A, van der Bruggen, C E, Jansen, S M A, Smits, A J, Smal, R, van Leeuwen, J W, Remedios, C D, Keogh, A, Humbert, M, Dorfmüller, P, Mercier, O, Guignabert, C, Niessen, H W M, Handoko, M L, Marcus, J T, Meijboom, L J, Oosterveer, F P T, Westerhof, B E, Heijboer, A C, Bogaard, H J, Noordegraaf, A V, Goumans, M J & de Man, F S 2022, ' Interplay of sex hormones and long-term right ventricular adaptation in a Dutch PAH-cohort ', Journal of Heart and Lung Transplantation, vol. 41, no. 4, pp. 445-457 . https://doi.org/10.1016/j.healun.2021.11.004
Journal of Heart and Lung Transplantation, 41(4), 445-457. ELSEVIER SCIENCE INC

BACKGROUND: To investigate the association between altered sex hormone expression and long-term right ventricular (RV) adaptation and progression of right heart failure in a Dutch cohort of Pulmonary Arterial Hypertension (PAH)-patients across a wide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d4dd802a7c4895dedb51dcb85dea6d9
https://research.vumc.nl/en/publications/adf739fe-a8b8-412a-880f-03a44d45aa95

Decellularization of porcine heart tissue to obtain extracellular matrix based hydrogels

Autor: Rabeil, Sakina, Aida, Llucià-Valldeperas, Ana, Henriques Lourenço, Abhishek, Harichandan, Sandro, Gelsomino, Paul, Wieringa, Carlos, Mota, Lorenzo, Moroni

Publikováno v: Methods in cell biology. 157

The use of hydrogels derived from the extracellular matrix (ECM) in tissue engineering applications aims to overcome the conundrum of mimicking the complexity of ECM composition in vitro. In this chapter, we describe a method of decellularization and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4c2465a932e470ca5cafd5860a1d0798
https://pubmed.ncbi.nlm.nih.gov/32334718