Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Aicha, Saadane"'
Autor:
Nicole El-Darzi, Natalia Mast, David A. Buchner, Aicha Saadane, Brian Dailey, Georgios Trichonas, Irina A. Pikuleva
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
A small dose of the anti-HIV drug efavirenz (EFV) was previously discovered to activate CYP46A1, a cholesterol-eliminating enzyme in the brain, and mitigate some of the manifestation of Alzheimer’s disease in 5XFAD mice. Herein, we investigated the
Externí odkaz:
https://doaj.org/article/ed746dc3793c44e1a259e662f90f526e
Autor:
Aicha Saadane, Alexey Petrov, Natalia Mast, Nicole El-Darzi, Tung Dao, Ahab Alnemri, Ying Song, Joshua L. Dunaief, Irina A. Pikuleva
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 12, Pp 2368-2382 (2018)
Apolipoprotein E (APOE) is a component of lipid-transporting particles and a recognition ligand for receptors, which bind these particles. The APOE isoform ε2 is a risk factor for age-related macular degeneration; nevertheless, APOE absence in human
Externí odkaz:
https://doaj.org/article/8e7f00fc91ce48059d39929de8c8557c
Autor:
Bruce A Berkowitz, Robert H Podolsky, Karen Lins Childers, Aicha Saadane, Timothy S Kern, Robin Roberts, Hailey Olds, Joydip Joy, Collin Richards, Tilman Rosales, Michael Schneider, Brennan Schilling, Arthur Orchanian, Emma Graffice, Kenan Sinan, Haohua Qian, Lamis Harp
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0245161 (2021)
PurposeThe phosphodiesterase inhibitor sildenafil is a promising treatment for neurodegenerative disease, but it can cause oxidative stress in photoreceptors ex vivo and degrade visual performance in humans. Here, we test the hypotheses that in wildt
Externí odkaz:
https://doaj.org/article/b014038296a542b78b217a813892662a
Autor:
Aicha Saadane, Alexander A. Veenstra, Martin S. Minns, Jie Tang, Yunpeng Du, Fatima Abubakr Elghazali, Emma M. Lessieur, Eric Pearlman, Timothy S. Kern
Publikováno v:
Diabetologia, vol 66, iss 3
Aims/hypothesis Accumulating evidence suggests that leucocytes play a critical role in diabetes-induced vascular lesions and other abnormalities that characterise the early stages of diabetic retinopathy. However, the role of monocytes has yet to be
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238727 (2020)
PurposeFemale mice have been found to be resistant to streptozotocin (STZ)-induced diabetes, and pre-clinical research related to diabetic complications commonly omits females. The purpose of this study was to develop a method to induce diabetes in f
Externí odkaz:
https://doaj.org/article/1a0d1aec47344c88ac9990711886ffcf
Autor:
Jennings C. Luu, Aicha Saadane, Henri Leinonen, Elliot H. Choi, Fangyuan Gao, Dominik Lewandowski, Maximilian Halabi, Christopher L. Sander, Arum Wu, Jacob M. Wang, Rupesh Singh, Songqi Gao, Emma M. Lessieur, Zhiqian Dong, Grazyna Palczewska, Robert F. Mullins, Neal S. Peachey, Philip D. Kiser, Marcin Tabaka, Timothy S. Kern, Krzysztof Palczewski
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Chronic, progressive retinal diseases, such as age-related macular degeneration (AMD), diabetic retinopathy, and retinitis pigmentosa, arise from genetic and environmental perturbations of cellular and tissue homeostasis. These disruptions accumulate
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
N,N-dimethyl-3β-hydroxycholenamide (DMHCA) is an experimental pharmaceutical and a steroidal liver X receptor (LXR) agonist, which does not induce undesired hepatic lipogenesis. Herein, DMHCA was evaluated for its retinal effects on normal C57BL/6J
Externí odkaz:
https://doaj.org/article/d441b06c1871469d803240d713e79c47
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 1, Pp 81-97 (2015)
Effects of serum cholesterol on cholesterol content in the retina are currently unknown. It is also unclear how cholesterol levels are controlled in the retina. High-cholesterol diet and oral administrations of simvastatin were used to modulate serum
Externí odkaz:
https://doaj.org/article/a44e95ea5bc0451e99451e63edc1129e
Autor:
Irina A. Pikuleva, Erin Prendergast, Tung Dao, Aicha Saadane, Ilya Bederman, Emmy Schwarz, Artem A. Astafev, Alexey M. Petrov, Natalia Mast, Nicole El-Darzi
Publikováno v:
Cellular and Molecular Life Sciences. 78:963-983
Apolipoprotein D (APOD) is an atypical apolipoprotein with unknown significance for retinal structure and function. Conversely, apolipoprotein E (APOE) is a typical apolipoprotein with established roles in retinal cholesterol transport. Herein, we im
Publikováno v:
Diabetologia. 65(10)
Induction of intercellular adhesion molecule-1 (ICAM-1) has been implicated in the development of macrovascular and microvascular diseases such as diabetic retinopathy. Lesions of diabetic retinopathy are unique to the retina but the reason for this