Výsledky vyhledávání - "Aiala Salvador"

Akademický článek

Overcoming the Inflammatory Stage of Non-Healing Wounds: In Vitro Mechanism of Action of Negatively Charged Microspheres (NCMs)

Autor: Edorta Santos-Vizcaino, Aiala Salvador, Claudia Vairo, Manoli Igartua, Rosa Maria Hernandez, Luis Correa, Silvia Villullas, Garazi Gainza

Publikováno v: Nanomaterials, Vol 10, Iss 6, p 1108 (2020)

Negatively charged microspheres (NCMs) represent a new therapeutic approach for wound healing since recent clinical trials have shown NCM efficacy in the recovery of hard-to-heal wounds that tend to stay in the inflammatory phase, unlocking the heali

Externí odkaz: https://doaj.org/article/3aef48e17b6f444e822ee8cad2a62755

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Computational and Experimental Evaluation of the Immune Response of Neoantigens for Personalized Vaccine Design

Autor: Iker Malaina, Lorena Gonzalez-Melero, Luis Martínez, Aiala Salvador, Ana Sanchez-Diez, Aintzane Asumendi, Javier Margareto, Jose Carrasco-Pujante, Leire Legarreta, María Asunción García, Martín Blas Pérez-Pinilla, Rosa Izu, Ildefonso Martínez de la Fuente, Manoli Igartua, Santos Alonso, Rosa Maria Hernandez, María Dolores Boyano

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 10; Pages: 9024

In the last few years, the importance of neoantigens in the development of personalized antitumor vaccines has increased remarkably. In order to study whether bioinformatic tools are effective in detecting neoantigens that generate an immune response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4574d1328e26faacde8a5168e2e2d0b2
https://doi.org/10.3390/ijms24109024

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Kosmetika onkologikoa: kimioterapiak eta erradioterapiak larruazalean eragindako efektu desiragaitzak eta horiek tratatzeko konposatu naturaletan oinarritutako formulazio berriak

Autor: Rosa Maria Hernandez, Edorta Santos-Vizcaino, Manoli Igartua, Aiala Salvador, José Luis Pedraz, A. Esquisabel, Miren Izaguirre

Publikováno v: Addi. Archivo Digital para la Docencia y la Investigación
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Sarritan, tratamendu onkologikoek pazientearen bizi-kalitatea baldintzatu dezaketen efektu desiragaitzak sortzen dituzte, minbizi-zelulak kaltetzeaz gain, bes-telako ehun osasuntsuak suntsitzen baitituzte. Lan honetan tratamendu onkologikoen ondorioz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aff78d2f3964fafb44979a20edea22e
http://hdl.handle.net/10810/38967

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Dissociation of skeletal muscle for flow cytometric characterization of immune cells in macaques

Autor: Aurélie Ploquin, Karin Loré, Gustaf Lindgren, José DelaO Hernández, Daphne A. Stanley, Hugues Fausther-Bovendo, Frank Liang, Richard A. Koup, Aiala Salvador Martinez, Nancy J. Sullivan, Jason M. Brenchley

Publikováno v: Journal of Immunological Methods. 425:69-78

The majority of vaccines and several treatments are administered by intramuscular injection. The aim is to engage and activate immune cells, although they are rare in normal skeletal muscle. The phenotype and function of resident as well as infiltrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad97feb40445aeef3058accdeb32694
https://doi.org/10.1016/j.jim.2015.06.011

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Designing improved poly lactic-co-glycolic acid microspheres for a malarial vaccine: incorporation of alginate and polyinosinic–polycytidilic acid

Autor: José Luis Pedraz, Rosa Maria Hernandez, Aiala Salvador, Manoli Igartua

Publikováno v: Journal of Microencapsulation. 31:560-566

Vaccination using proteins and peptides is currently gaining importance. One of the major drawbacks of this approach is the lack of an efficient immune response when the antigens are administered without adjuvants. In this study, we have taken the ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0807feb13cb40184bccf8a3f8317ba54
https://doi.org/10.3109/02652048.2014.885608

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Plasmodium falciparummalaria vaccines: current status, pitfalls and future directions

Autor: Rosa Maria Hernandez, Manoli Igartua, José Luis Pedraz, Aiala Salvador

Publikováno v: Expert Review of Vaccines. 11:1071-1086

Currently, a vaccine against malaria has not yet been licensed. Different approaches have been explored with different immune responses, but neither has fulfilled the criteria for being approved. The most advanced candidate, RTS,S, is undergoing Phas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde9218d4347566576c8bc2212ad69a6
https://doi.org/10.1586/erv.12.87

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Combination of immune stimulating adjuvants with poly(lactide-co-glycolide) microspheres enhances the immune response of vaccines

Autor: José Luis Pedraz, Rosa Ma Hernández, Aiala Salvador, Manoli Igartua

Publikováno v: Vaccine. 30:589-596

The development of vaccines that generate mixed humoral and cellular immune responses is a challenge in vaccinology. Poly(lactide-co-glycolide) microspheres are vaccine adjuvants which possess the advantage of allowing the coencapsulation of other ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d50e4483f44dc3736f5d404613539e0
https://doi.org/10.1016/j.vaccine.2011.11.057

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An Overview on the Field of Micro- and Nanotechnologies for Synthetic Peptide-Based Vaccines

Autor: José Luis Pedraz, Manoli Igartua, Rosa María Hernández, Aiala Salvador

Publikováno v: Journal of Drug Delivery
Addi. Archivo Digital para la Docencia y la Investigación
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Journal of Drug Delivery, Vol 2011 (2011)

18 p. The development of synthetic peptide-based vaccines has many advantages in comparison with vaccines based on live attenuated organisms, inactivated or killed organism, or toxins. Peptide-based vaccines cannot revert to a virulent form, allow a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83446faba7546b679d2c220bf4264a26

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Design and evaluation of surface and adjuvant modified PLGA microspheres for uptake by dendritic cells to improve vaccine responses

Autor: Aiala Salvador, Elizabeth A. Thompson, Kerrie J. Sandgren, José Luis Pedraz, Richard A. Koup, Manoli Igartua, Frank Liang, Karin Loré, Rosa Maria Hernandez

Publikováno v: International journal of pharmaceutics. 496(2)

Designing strategies for targeting antigens to dendritic cells is a major goal in vaccinology. Here, PLGA (poly lactic-co-glycolic acid) microspheres and with several surface modifications that affect to their uptake by human blood primary dendritic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cafc880e1a1394e28eee60405e8fb644
https://pubmed.ncbi.nlm.nih.gov/26475970

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Malaria Vaccine Adjuvants: Latest Update and Challenges in Preclinical and Clinical Research

Autor: José Luis Pedraz, Rosa Maria Hernandez, Elena Mata, Aiala Salvador, Manoli Igartua

Publikováno v: BioMed Research International, Vol 2013 (2013)
Addi. Archivo Digital para la Docencia y la Investigación
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BioMed Research International

There is no malaria vaccine currently available, and the most advanced candidate has recently reported a modest 30% efficacy against clinical malaria. Although many efforts have been dedicated to achieve this goal, the research was mainly directed to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda2a553534df603fcda9a06f133be94
https://doaj.org/article/b63d850f9ff24c4694ac658f75dc5a07

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