Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ai-Leen Lam"'
Autor:
Åsa Andersson, Maree T. Smith, Ai Leen Lam, Julia Magiera, Nursyazwani Rethwan, Andy Kuo, Wim Meutermans, Richard J. Lewis, Bruce D. Wyse
Publikováno v:
European Journal of Pharmacology. 872:172947
Previously, we showed that no two of seven opioids administered by the intracerebroventricular route had the same potency rank order for evoking antinociception, constipation and respiratory depression in rats. To gain insight at the cellular level,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00fc358c463ce7fc4725fa2aabe0240
https://doi.org/10.1016/j.ejphar.2020.172947
https://doi.org/10.1016/j.ejphar.2020.172947
Autor:
Andy Kuo, Jiawei Shi, Zhiying Zhu, Luofan Ni, Maree T. Smith, Julia Magiera, Saijian Shi, Ai Leen Lam, Tingyou Li, Sunderajhan Sekar, Yajuan Qin
Publikováno v:
ACS chemical neuroscience. 10(1)
A series of fentanyl analogues modified at the phenyl group of the phenethyl with alkyl and/or hydroxyl and alkoxy, and the phenyl group in the anilido moiety replaced with benzyl or substituted benzyl, were synthesized. The in vitro opioid receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7463038be4655262b2c9fe3a260beaa
https://pubmed.ncbi.nlm.nih.gov/30179508
https://pubmed.ncbi.nlm.nih.gov/30179508
Publikováno v:
Journal of Pharmaceutical Sciences. 104:2334-2344
Intractable cancer-related pain complicated by a neuropathic component due to nerve impingement is poorly alleviated even by escalating doses of a strong opioid analgesic. To address this unmet medical need, we developed sustained-release, bioerodabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4ca67bf9b7f1a0058cb2be07a6d719
https://doi.org/10.1002/jps.24497
https://doi.org/10.1002/jps.24497
Autor:
Ai-Leen Lam, Bowen Song, Sunder Sekar, Cai Jun, Akihiro Ambo, Ma Yu, Lawrence H. Lazarus, Maree T. Smith, Julia Magiera, Bruce D. Wyse, Tingyou Li, Yunxin Cai, Yusuke Sasaki
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:2208-2219
Analogues of endomorphin (Dmt-Pro-Xaa-Xaa-NH2) modified at position 4 or at positions 4 and 3, and tripeptides (Dmt-Pro-Xaa-NH2) modified at position 3, with various phenylalanine analogues (Xaa=Trp, 1-Nal, 2-Nal, Tmp, Dmp, Dmt) were synthesized and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303b5849d4a8b5e37b2459c41ef22f58
https://doi.org/10.1016/j.bmc.2014.02.015
https://doi.org/10.1016/j.bmc.2014.02.015
Publikováno v:
Proceedings of the National Academy of Sciences. 103:4186-4191
Human centromeres are specialized chromatin domains containing the centromeric histone H3 variant CENP-A. CENP-A nucleosomes are interspersed with nucleosomes containing histone H3 dimethylated at lysine 4, distinguishing centromeric chromatin (CEN c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d1160c5d2e18bcbf35c33dc9a2214e
https://doi.org/10.1073/pnas.0507947103
https://doi.org/10.1073/pnas.0507947103
Publikováno v:
Chromosoma. 114:242-251
Epigenetic regulation of higher-order chromatin structure controls gene expression and the assembly of chromosomal domains during cell division, differentiation, and development. The proposed "histone code" integrates a complex system of histone modi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc377aa99bf7f44872e576357dde09c
https://doi.org/10.1007/s00412-005-0001-0
https://doi.org/10.1007/s00412-005-0001-0
Publikováno v:
Frontiers in Pharmacology; 3/14/2016, p1-14, 14p
Publikováno v:
Chromosoma; Sep2005, Vol. 114 Issue 4, p242-251, 10p, 2 Diagrams, 1 Chart