Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ai-Ching Wong"'
Autor:
Diana Zatreanu, Helen M. R. Robinson, Omar Alkhatib, Marie Boursier, Harry Finch, Lerin Geo, Diego Grande, Vera Grinkevich, Robert A. Heald, Sophie Langdon, Jayesh Majithiya, Claire McWhirter, Niall M. B. Martin, Shaun Moore, Joana Neves, Eeson Rajendra, Marco Ranzani, Theresia Schaedler, Martin Stockley, Kimberley Wiggins, Rachel Brough, Sandhya Sridhar, Aditi Gulati, Nan Shao, Luned M. Badder, Daniela Novo, Eleanor G. Knight, Rebecca Marlow, Syed Haider, Elsa Callen, Graeme Hewitt, Joost Schimmel, Remko Prevo, Christina Alli, Amanda Ferdinand, Cameron Bell, Peter Blencowe, Chris Bot, Mathew Calder, Mark Charles, Jayne Curry, Tennyson Ekwuru, Katherine Ewings, Wojciech Krajewski, Ellen MacDonald, Hollie McCarron, Leon Pang, Chris Pedder, Laurent Rigoreau, Martin Swarbrick, Ed Wheatley, Simon Willis, Ai Ching Wong, Andre Nussenzweig, Marcel Tijsterman, Andrew Tutt, Simon J. Boulton, Geoff S. Higgins, Stephen J. Pettitt, Graeme C. M. Smith, Christopher J. Lord
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Polθ has been recently identified as a therapeutic target in cancer but specific inhibitors are currently unavailable. Here, the authors identify small molecule inhibitors of Polθ’s polymerase activity which elicit BRCA1/2 synthetic lethality, en
Externí odkaz:
https://doaj.org/article/a5462d8522964b13a5f79a9e1b35250a
Autor:
Duncan C. Miller, Tristan Reuillon, Lauren Molyneux, Timothy Blackburn, Simon J. Cook, Noel Edwards, Jane A. Endicott, Bernard T. Golding, Roger J. Griffin, Ian Hardcastle, Suzannah J. Harnor, Amy Heptinstall, Pamela Lochhead, Mathew P. Martin, Nick C. Martin, Stephanie Myers, David R. Newell, Richard A. Noble, Nicole Phillips, Laurent Rigoreau, Huw Thomas, Julie A. Tucker, Lan-Zhen Wang, Michael J. Waring, Ai-Ching Wong, Stephen R. Wedge, Martin E. M. Noble, Celine Cano
Publikováno v:
Journal of Medicinal Chemistry. 65:6513-6540
The nonclassical extracellular signal-related kinase 5 (ERK5) mitogen-activated protein kinase pathway has been implicated in increased cellular proliferation, migration, survival, and angiogenesis; hence, ERK5 inhibition may be an attractive approac
Autor:
Christina Alli, Christopher J. Lord, Marcel Tijsterman, Katherine Ewings, Marco Ranzani, Ai Ching Wong, Claire McWhirter, Martin Swarbrick, Harry Finch, Robert A. Heald, Rachel Brough, Nan Shao, Rebecca Marlow, Shaun Moore, Vera Grinkevich, Ellen Macdonald, Jayne Curry, Helen M. R. Robinson, Graeme Hewitt, Eleanor Knight, Christopher Bot, Syed Haider, Mathew Calder, Theresia A. Schaedler, Hollie McCarron, Luned M. Badder, Aditi Gulati, Martin Stockley, Eeson Rajendra, Sophie Langdon, Stephen J. Pettitt, Simon J. Boulton, Chris Pedder, Elsa Callen, Ed Wheatley, Wojciech Krajewski, André Nussenzweig, Daniela Novo, Peter Blencowe, Jayesh B. Majithiya, Laurent Rigoreau, Lerin Geo, Cameron Bell, Kimberley A. Wiggins, Diana Zatreanu, Geoff S. Higgins, Remko Prevo, Tennyson Ekwuru, Leon Pang, Simon N. Willis, Sandhya Sridhar, Marie Boursier, Diego Grande, Joana F. Neves, Mark Charles, Joost Schimmel, Andrew Tutt, Niall M. B. Martin, Omar Alkhatib, Amanda Ferdinand, Graeme C. M. Smith
Publikováno v:
Nature Communications, 12(1). NATURE RESEARCH
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
To identify approaches to target DNA repair vulnerabilities in cancer, we discovered nanomolar potent, selective, low molecular weight (MW), allosteric inhibitors of the polymerase function of DNA polymerase Polθ, including ART558. ART558 inhibits t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50fa596497393cd588028cd95531690
https://hdl.handle.net/1887/3213877
https://hdl.handle.net/1887/3213877
Autor:
Simon J. Cook, Mathew P. Martin, Julie A. Tucker, Miller Duncan Charles, Timothy J. Blackburn, Stephanie M. Myers, Ai-Ching Wong, Nick C. Martin, Mercedes Arasta, Martin E.M. Noble, Huw D. Thomas, Ruth H. Bawn, Lan-Zhen Wang, Noel Edwards, Pamela A. Lochhead, Celine Cano, Suzannah J. Harnor, Tristan Reuillon, Laurent Rigoreau, Lauren Molyneux, Roger J. Griffin, David R. Newell, Bernard T. Golding, Tim Hammonds, Amy B. Heptinstall, P.J. Owen, Stephen R. Wedge, Ian R. Hardcastle, Leon Pang, Jane A. Endicott
Extracellular regulated kinase 5 (ERK5) signalling has been implicated in driving a number of cellular phenotypes including endothelial cell angiogenesis and tumour cell motility. Novel ERK5 inhibitors were identified using high throughput screening,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b20469b74ddfa9b4388aacc50467a77
https://eprints.whiterose.ac.uk/148098/1/ERK5LeadIDPaper_EurJMedChem_2019_04_29.docx
https://eprints.whiterose.ac.uk/148098/1/ERK5LeadIDPaper_EurJMedChem_2019_04_29.docx
Autor:
Michael F. Olson, John Dunn, Ai Ching Wong, Tim Hammonds, Gavin Greenland, Susan M. Boyd, Diane Crighton, Mark Charles, Anne Cheasty, Tennyson Ekwuru, Joanna Brookfield, Martin Stockley, Michelle Riddick, Elisabeth Trivier
Publikováno v:
Journal of Medicinal Chemistry. 58:8309-8313
As part of a program to develop a small molecule inhibitor of LIMK, a series of aminothiazole inhibitors were discovered by high throughput screening. Scaffold hopping and subsequent SAR directed development led to a series of low nanomolar inhibitor
Autor:
Timothy J. Blackburn, Roger J. Griffin, Tim Hammonds, Betty Cottyn, Ian R. Hardcastle, Sandrine Vidot, Lauren Molyneux, Bernard T. Golding, Celine Cano, William Clegg, Ruth H. Bawn, Louise Bisset, Hing Y. Leung, David R. Newell, Ai-Ching Wong, Stephanie M. Myers, Laurent Rigoreau, Ross W. Harrington
Publikováno v:
ACS Combinatorial Science
ACS Combinatorial Science, ACS, 2016, 18, pp.444-455. ⟨10.1021/acscombsci.5b00155⟩
ACS Combinatorial Science (18), 444-455. (2016)
ACS Combinatorial Science, ACS, 2016, 18, pp.444-455. ⟨10.1021/acscombsci.5b00155⟩
ACS Combinatorial Science (18), 444-455. (2016)
International audience; The extracellular-related kinase 5 (ERK5) is a promising target for cancer therapy. A high-throughput screen was developed for ERK5, based on the IMAP FP progressive binding system, and used to identify hits from a library of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::002ffb5033573e80911c966b43ada6d9
https://eprints.gla.ac.uk/139945/1/139945.pdf
https://eprints.gla.ac.uk/139945/1/139945.pdf
Autor:
Tim Hammonds, Ai Ching Wong, Margaret Ainger, Mokdad Mezna, Michael F. Olson, Rebecca W. Scott
Publikováno v:
SLAS Discovery. 17:460-468
Kinases are attractive drug targets because of the central roles they play in signal transduction pathways and human diseases. Their well-formed adenosine triphosphate (ATP)-binding pockets make ideal targets for small-molecule inhibitors. For drug d
Autor:
Siobhan M. Hughes, Patricia Haus, Vanessa Petrucci, Thomas Leiser, Matthew J. Fuchter, S.S. Samlal, Andrew J. P. White, Robert J.K. Wood, Stephen Neidle, Fabrice Turlais, Matthias G. J. Baud, Ai Ching Wong, Lakjaya Buluwela, Franz-Josef Meyer-Almes, Mekala Gunaratnam
Publikováno v:
Journal of medicinal chemistry. 55(4)
Psammaplin A (11c) is a marine metabolite previously reported to be a potent inhibitor of two classes of epigenetic enzymes: histone deacetylases and DNA methyltransferases. The design and synthesis of a focused library based on the psammaplin A core
Autor:
Jenny McKelvie, Kelly A. Holmes, Julie Stock, Aurore Lejeune, Stephen S. Myatt, Michelle Barnard, Jon Roffey, Ai Ching Wong, Jason S. Carroll
Publikováno v:
Cancer Research. 75:LB-125
Estrogen receptor alpha (ERα) is expressed in ∼75% of breast cancers where it binds and regulates specific target genes which drive cancer cell proliferation. Hormone-based treatments such as selective estrogen receptor modulators (SERMs) and arom
Autor:
Myers, Stephanie M., Bawn, Ruth H., Bisset, Louise C., Blackburn, Timothy J., Cottyn, Betty, Molyneux, Lauren, Ai-Ching Wong, Cano, Celine, Clegg, William, Harrington, Ross. W., Hing Leung, Rigoreau, Laurent, Vidot, Sandrine, Golding, Bernard T., Griffin, Roger J., Hammonds, Tim, Newell, David R., Hardcastle, Ian R.
Publikováno v:
ACS Combinatorial Science; 8/8/2016, Vol. 18 Issue 8, p444-455, 12p