Výsledky vyhledávání - "Ai Takeda-Watanabe"

Anagliptin ameliorates albuminuria and urinary liver-type fatty acid-binding protein excretion in patients with type 2 diabetes with nephropathy in a glucose-lowering-independent manner

Autor: Munehiro Kitada, Ai Takeda-Watanabe, Atsushi Nakagawa, Keizo Kanasaki, Shin-ichi Tsuda, Daisuke Koya, Makoto Nishizawa, Kazunori Konishi, Mizue Fujii

Publikováno v: BMJ Open Diabetes Research & Care

Objective The objective of this study is to elucidate the effect of anagliptin on glucose/lipid metabolism and renoprotection in patients with type 2 diabetic nephropathy. Methods Twenty-five patients with type 2 diabetic nephropathy received anaglip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff0afb4910790540e9efac2bbb0255f
http://europepmc.org/articles/PMC5530236

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Restoration of the Hypothalamic-pituitary-adrenal Response to Hypoglycemia in Type 2 Diabetes by Avoiding Chronic Hypoglycemia

Autor: Toshiki Otoda, Makoto Nishizawa, Atsushi Nakagawa, Kazunori Konishi, Munehiro Kitada, Shin-ichi Tsuda, Daisuke Koya, Keizo Kanasaki, Megumi Kanasaki, Takako Nagai, Ai Takeda-Watanabe

Publikováno v: Internal Medicine

An impaired ability to sense and respond to drug-induced hypoglycemia is a common and serious complication in diabetic patients. The hypothalamic-pituitary-adrenal (HPA) axis activity plays a critical role in the counterregulatory response to hypogly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca87587495fbaeaf47cc1632d5920b3
https://pubmed.ncbi.nlm.nih.gov/27904111

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Sirtuins and renal diseases: relationship with aging and diabetic nephropathy

Autor: Munehiro Kitada, Shinji Kume, Ai Takeda-Watanabe, Keizo Kanasaki, Daisuke Koya

Publikováno v: Clinical Science (London, England : 1979)

Sirtuins are members of the Sir2 (silent information regulator 2) family, a group of class III deacetylases. Mammals have seven different sirtuins, SIRT1–SIRT7. Among them, SIRT1, SIRT3 and SIRT6 are induced by calorie restriction conditions and ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4055ae0b65db646f19c8a4a1d9c7496
https://doi.org/10.1042/cs20120190

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Three ileus cases associated with the use of dipeptidyl peptidase-4 inhibitors in diabetic patients

Autor: Ai Takeda-Watanabe, Tomoe Nomura, Atsushi Nakagawa, Yasuto Tomita, Ranji Hayashi, Yasuharu Nakano, Munehiro Kitada, Hisakazu Shiroeda, Shin-ichi Tsuda, Takako Nagai, Takeo Kosaka, Keizo Kanasaki, Nobuhiko Ueda, Megumi Kanasaki, Daisuke Koya, Makoto Nishizawa, Kazunori Konishi, Hiroki Ito, Mizue Fujii

Publikováno v: Journal of Diabetes Investigation

Dipeptidyl peptidase (DPP)‐4 inhibitors are a new class of antidiabetic drugs that increase incretin hormone levels to enhance blood sugar level‐dependent insulinotropic effects, suppress glucagon action, and reduce bowel motility. These incretin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0e73dcbcf3a1384beb196eb3983cc1
https://doi.org/10.1111/jdi.12095

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Calorie restriction in overweight males ameliorates obesity-related metabolic alterations and cellular adaptations through anti-aging effects, possibly including AMPK and SIRT1 activation

Autor: Munehiro Kitada, Keizo Kanasaki, Shin-ichi Tsuda, Ai Takeda-Watanabe, Shinji Kume, Daisuke Koya

Publikováno v: Biochimica et biophysica acta. 1830(10)

Background Calorie restriction (CR) is accepted as an experimental anti-aging paradigm. Several important signal transduction pathways including AMPK and SIRT1 are implicated in the regulation of physiological processes of CR. However, the mechanisms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c0d3655facc17cb2d1f5b89dad360a
https://pubmed.ncbi.nlm.nih.gov/23800577

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