Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Ai Sheng Ho"'
Autor:
Yi-Fang Chang, Ken-Hong Lim, Ya-Wen Chiang, Zong-Lin Sie, Jungshan Chang, Ai-Sheng Ho, Chun-Chia Cheng
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-14 (2019)
Abstract Background HER3 mediates drug resistance against epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs), resulting in tumor relapse in lung cancers. Previously, we demonstrated that EGFR induces HER3 overexpression, which
Externí odkaz:
https://doaj.org/article/cb61132664c64b758ae2440f5c1e07b1
Autor:
Chih-Liang Wang, Ai-Sheng Ho, Chun-Chao Chang, Zong-Lin Sie, Cheng-Liang Peng, Jungshan Chang, Chun-Chia Cheng
Publikováno v:
Cancer Immunology, Immunotherapy. 72:1865-1880
Radiotherapy (RT) not only damages tumors but also induces interferon (IFN) expression in tumors. IFNs mediate PD-L1 to exhaust CD8+ T cells, but which also directly impact tumor cells and potentially activate anti-tumor immune surveillance. Little i
Autor:
Chun-Chia Cheng, Po-Nien Liao, Ai-Sheng Ho, Ken-Hong Lim, Jungshan Chang, Ying-Wen Su, Caleb Gon-Shen Chen, Ya-Wen Chiang, Bi-Ling Yang, Huan-Chau Lin, Yu-Cheng Chang, Chun-Chao Chang, Yi-Fang Chang
Publikováno v:
Journal of Biomedical Science, Vol 25, Iss 1, Pp 1-12 (2018)
Abstract Background Cancer stem cells are capable of undergoing cell division after surviving cancer therapies, leading to tumor progression and recurrence. Inhibitory agents against cancer stem cells may be therapeutically used for efficiently eradi
Externí odkaz:
https://doaj.org/article/6fa8fbb263aa47dc8b21de866be2cfc8
Autor:
Chun-Chia Cheng, Yi-Fang Chang, Ai-Sheng Ho, Zong-Lin Sie, Jung-Shan Chang, Cheng-Liang Peng, Chun-Chao Chang
Publikováno v:
Biomedicines, Vol 9, Iss 10, p 1349 (2021)
Irradiation-broken DNA fragments increase type I interferon and chemokines secretion in tumor cells. Since radiotherapy may augment tumor immunotherapy, we hypothesize that the chemokines increased by irradiation could recruit CD8+ T cells to suppres
Externí odkaz:
https://doaj.org/article/ce04b150a5124871b008367f2df050a0
Autor:
Chun-I. Wang, Yi-Fang Chang, Zong-Lin Sie, Ai-Sheng Ho, Jung-Shan Chang, Cheng-Liang Peng, Chun-Chia Cheng
Publikováno v:
Cells, Vol 10, Iss 10, p 2515 (2021)
Tumor cells express immune checkpoints to exhaust CD8+ T cells. Irradiation damages tumor cells and augments tumor immunotherapy in clinical applications. However, the radiotherapy-mediated molecular mechanism affecting CD8+ T cell activity remains e
Externí odkaz:
https://doaj.org/article/4b52418cbd594aae840c6aa3d1c19614
Autor:
Wei-Chen Lin, Wei-Chen Tai, Chung-Hsin Chang, Chia-Hung Tu, I-Che Feng, Ming-Jium Shieh, Chen-Shuan Chung, Hsu-Heng Yen, Jen-Wei Chou, Jau-Min Wong, Yu-Hwa Liu, Tien-Yu Huang, Chiao-Hsiung Chuang, Tzung-Jiun Tsai, Feng-Fan Chiang, Chien-Yu Lu, Wen-Hung Hsu, Fang-Jung Yu, Te-Hsin Chao, Deng-Chyang Wu, Ai-Sheng Ho, Hung-Hsin Lin, Chun-Lung Feng, Keng-Liang Wu, Ming-Wun Wong, Chien-Chih Tung, Chun-Chi Lin, Chia-Chang Chen, Huang-Ming Hu, Lung-Sheng Lu, Huann-Sheng Wang, I-Chen Wu, Hsin-Yu Kuo, Jia-Feng Wu, Hsiang Yao Shih, Yen-Hsuan Ni, Shu-Lun Tang, Peng-Hsu Chen, Shu-Chen Wei
Publikováno v:
Inflammatory Bowel Diseases.
Background This nationwide prospective registry study investigated the real-world effectiveness, safety, and persistence of vedolizumab (VDZ) in inflammatory bowel disease (IBD) patients in Taiwan. Disease relapse rates after VDZ discontinuation due
Autor:
Chih-Liang Wang, Ai-Sheng Ho, Chun-Chao Chang, Zong-Lin Sie, Cheng-Liang Peng, Jungshan Chang, Chun-Chia Cheng
Radiotherapy (RT) not only damages tumors but also induces interferon (IFN) expression in tumors. IFNs-mediate PD-L1 exhausts CD8+ T cells but which also directly impact tumor cells and potentially activate anti-tumor immune surveillance. Little is k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5d0257f5623cb181451dbcc2b9f280f
https://doi.org/10.21203/rs.3.rs-2204386/v1
https://doi.org/10.21203/rs.3.rs-2204386/v1
Autor:
Chun-Chia Cheng, Bi-Ling Yang, Wen-Chao Chen, Ai-Sheng Ho, Zong-Lin Sie, Hsin-Chi Lin, Chun-Chao Chang
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7315 (2020)
Signal transducer and activator of transcription 3 (STAT3), a transcriptional factor involved in tumorigenesis and cancer stemness formation, contributes to drug resistance in cancer therapies. STAT3 not only mediates gene transcription but also part
Externí odkaz:
https://doaj.org/article/fed23275c3c74d29893efbdad4ae95ea
Autor:
Chun-Chia Cheng, Jungshan Chang, Stanley Ching-Cheng Huang, Huan-Chau Lin, Ai-Sheng Ho, Ken-Hong Lim, Chun-Chao Chang, Ling Huang, Yu-Cheng Chang, Yi-Fang Chang, Cheng-Wen Wu
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182149 (2017)
Cancer stem cell survival is the leading factor for tumor recurrence after tumor-suppressive treatments. Therefore, specific and efficient inhibitors of cancer stemness must be discovered for reducing tumor recurrence. YM155 has been indicated to sig
Externí odkaz:
https://doaj.org/article/60ce4b2bc6fc42939c1b03b8255c5c8d
Autor:
Yi Fang Chang, Bi Ling Yang, Zong Lin Sie, Cheng Liang Peng, Jungshan Chang, Ya Wen Chiang, Ai Sheng Ho, Ken-Hong Lim, Chun Chia Cheng, Hsin Chi Lin
Publikováno v:
Cancer Immunology, Immunotherapy. 70:1351-1364
The mechanism exhausting CD8+ T cells is not completely clear against tumors. Literature has demonstrated that cigarette smoking disables the immunological activity, so we propose nicotine is able to exhaust CD8+ T cells. The CD8+ T cells from health