Design, Synthesis, and Molecular Docking Study of Novel 3-Cyanopyridine Derivatives for the Anti-Cancer Drug Target Survivin Protein

Autor: Ai-Qun Wu, Li-Qun Shen, Jia-Hao Lu, Wu-Ji Lai, Li-He Jiang, Fu-Hou Lei

Publikováno v: Medicinal chemistry (Shariqah (United Arab Emirates)).

Background: Survivin is an important member of the antiapoptotic protein family and controls the cell’s life cycle. Overexpression of survivin in tumor cells leads to inhibition of apoptosis, thus contributing to cancer cell proliferation. The larg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a1c76697af4b560e53e11dad1cc0daf
https://pubmed.ncbi.nlm.nih.gov/36043763

Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations

Autor: Laurie Burdette, Xiao-Hang Zhao, Guo-Lan Xing, Yin Li, Chaoyu Wang, Yu-Tang Gao, Jin Wang, William Wheeler, Ying Huang, Shengli Zhou, Haijun Yang, Teng Ma, Peter Kraft, She-Gan Gao, Chang-Wei Feng, Xiaoping Miao, Li-Sha Chen, Shu-Wei Ren, Hongbing Shen, Dongxin Lin, Zhaoming Wang, Yifeng Zhou, Woon-Puay Koh, Ilyar Sheyhidin, Zhao Xueke, Yi-Min Mao, Wei Hua Jia, Li Bei, Ji-Lin Li, Wen-Bin Yue, Wancai Yang, Xiu-Qing Peng, Maxwell P. Lee, Ya-Li Liu, Xiao Liu, Yang Ke, Liangdan Sun, Ying-Fa Zhou, Charles C. Chung, Nan Hu, Bin Liu, Xiao-Shan Feng, Margaret A. Tucker, Ti Ding, Yu Liu, Amy Hutchinson, Alisa M. Goldstein, Xiu-Min Li, En-Min Li, Kan Zhai, Yan Li, Zhi-Qing Yuan, Jing Liu, Jian-Wei Ku, Yuan Yuan, Yan-Rui Zhang, Zhihua Liu, Guang-Yan Lei, Qi-De Bao, Qimin Zhan, Wei Zheng, Wu Wei, Sa Tang, Er-Tao Guo, Qirenwang Qige, Linda M. Liao, Yu-Hua Yang, Jin-Hu Fan, Shuqing Chen, Wen-Jun Yang, Neal D. Freedman, Xi Chen, Kevin B. Jacobs, Jianhua Fu, Philip R. Taylor, Ze-Zhong Tang, Stephen J. Chanock, Kai Yu, Meredith Yeager, Zhou Fuyou, Ran Wang, Yan-Long Hu, Xiao-Ou Shu, Jeff Yuenger, Wen Tan, Feng Li, Ling Yuan, Guangfu Jin, Zhi-Chao Hou, Ji-Li Cui, Jie He, Changdong Lu, Jing-Jing Han, Zhibin Hu, Xuejun Zhang, Chunling Liu, Min Han, Yi Xin Zeng, Hong-Zhang Hao, Chen Wu, Jian-Min Yuan, Chuanhai Guo, Bao-Chi Liu, Li Sun, Xin-Min Li, Christian C. Abnet, Long-Qi Chen, Liu Qin Yang, Yan Qiao, Wei Zhang, Peng Zhang, Mitchell H. Gail, Hong-Li Lin, Lixuan Wei, Zhou Wang, Tangchun Wu, Hui Meng, Joseph F. Fraumeni, Dongyun Zhang, Guo Yuan, Carol Giffen, Zong-Min Fan, Lu-Wen Wang, Dianke Yu, Sanford M. Dawsey, Bao-Gen Ma, Xue-Min Li, Jun-Yan Hong, Jiang Chang, Xue-Ping Fan, Ai-Li Li, Yong-Bing Xiang, Mei Zhang, Fang-Heng Zhu, Qing-Peng Kong, Li-Dong Wang, Li Wang, Dong Xie, Xianbo Zuo, Xin Song, Jing-Li Ren, You-Lin Qiao, Liang Wang, Weixing Zhao, Zhonghu He, Han Xuena, Ai-Qun Wu

Publikováno v: Nature genetics

We conducted a joint (pooled) analysis of three genome-wide association studies (GWAS) of esophageal squamous cell carcinoma (ESCC) in individuals of Chinese ancestry (5,337 ESCC cases and 5,787 controls) with 9,654 ESCC cases and 10,058 controls for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae436ee982f6aa16938e933e73a86aa
http://europepmc.org/articles/PMC4212832

Observation and measurements of long thoracic nerve: a cadaver study and clinical consideration

Autor: Er-yu Chen, Ai-qun Wu, Dong Wang, Zhen Liu, Zhi-ying Zhang, Chuan-sen Zhang, Hui-Long Huang, Rui-Shan Dang, Jia-Feng Wang

Publikováno v: Surgical and Radiologic Anatomy. 30:569-573

Long thoracic nerve (LTN) is an important nerve originating from cervical nerve roots. It varies a lot in origins and branches, which lead to several clinical problems, such as diagnosis, prophylaxis and treatment of LTN injury. LTN was dissected in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaed05a940479aa4ff351f59577cd737
https://doi.org/10.1007/s00276-008-0368-8

Constraints on the nucleation rate in extended inflation

Autor: Ai-qun Wu

Publikováno v: Physical Review D. 45:2653-2664

We study the newly proposed extended inflation models in detail. We show through explicit examples that the $\ensuremath{\omega}(\ensuremath{\Phi})$ generalization of the original extended inflation might not be satisfactory because of severe constra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c3f6d7322f667f65e77a5383510b3b
https://doi.org/10.1103/physrevd.45.2653

[Effect of Salvia miltiorrhiza on neuropeptide Y1-36 and calcitonin gene-related peptide in neonatal rats with hypoxia-ischemic brain injury]

Autor: Xin-ru, Hong, Ai-qun, Wu, Zhen-dong, You

Publikováno v: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 22(8)

To observe the effects of Salvia miltiorrhiza (SM) on levels of neuropeptide Y1-36 and calcitonin gene-related peptide immune reactive substances (ir-NPY, ir-CGRP) in blood plasma and pons-oblongata after hypoxia-ischemic brain injury (HIBI) in neona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8720c8c3a730b821caac580202e78422
https://pubmed.ncbi.nlm.nih.gov/12572384