Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Ai M. Fletcher"'
Publikováno v:
Journal of Natural Products. 85:306-312
Autor:
David Reza, Rosalino Balo, Jose M. Otero, Ai M. Fletcher, Rebeca García-Fandino, Victor M. Sanchez-Pedregal, Stephen G. Davies, Ramon J. Estevez, Juan C. Estevez
We describe the synthesis of trihydroxylated cyclohexane β-amino acids from (–)-shikimic acid, in their cis and trans configuration, and the incorporation of the trans isomer into a trans-2-aminocyclohexanecarboxylic acid peptide chain. Subsequent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::325ef2db0e5f65058856a31c77d0ff75
https://doi.org/10.26434/chemrxiv-2022-zdb5j
https://doi.org/10.26434/chemrxiv-2022-zdb5j
Publikováno v:
Journal of natural products. 85(7)
The first asymmetric synthesis of microgrewiapine C, a piperidine alkaloid isolated from
Publikováno v:
Organic & Biomolecular Chemistry. 17:1322-1335
The SuperQuat (4-substituted 5,5-dimethyloxazolidine-2-one) family of chiral auxiliaries was first developed by us in the 1990s to address the shortcomings of the Evans (4-substituted oxazolidin-2-one) family of chiral auxiliaries. The incorporation
Publikováno v:
Organicbiomolecular chemistry. 19(13)
Enantiorecognition between a racemic reagent and a racemic substrate can be a valuable process in organic synthesis. This review highlights representative examples of this phenomenon and the use of mutual kinetic resolution as a method for screening
d -Fagomine (1,2,5-trideoxy-1,5-imino-d-arabino-hexitol), a naturally occurring polyhydroxylated piperidine (iminosugar), and its stereoisomers display important biological activities such as glycosidase inhibition. This review delineates both de nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed7b05d8007a539a7ffcb42fed58edf
https://doi.org/10.1016/j.tet.2019.130727
https://doi.org/10.1016/j.tet.2019.130727
The key step in our synthetic strategy towards (S,S)-methylphenidate hydrochloride employs the ring-opening of an in situ formed aziridinium intermediate. Treatment of an α-hydroxy-β-amino ester with methanesulfonic anhydride promoted aziridinium f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b759c4fcb617a328d37682b5ae79051c
https://doi.org/10.1016/j.tet.2019.130713
https://doi.org/10.1016/j.tet.2019.130713
Autor:
Francis Xavier Wilson, Isabel V.L. Wilkinson, Jessica A. Rowley, Stephen G. Davies, Maria Chatzopoulou, Graham Michael Wynne, D. Elsey, Ai M. Fletcher, Enrico Emer, Timothy D. W. Claridge, Angela J. Russell, Jonathon M. Tinsley, Neil Robinson, Kay E. Davies, Richard Weaver, Nicky J. Willis, Shawn Harriman
Publikováno v:
Journal of Medicinal Chemistry.
5-(Ethylsulfonyl)-2-(naphthalen-2-yl)benzo[d]oxazole (ezutromid, 1) is a first-in-class utrophin modulator that has been evaluated in a phase 2 clinical study for the treatment of Duchenne muscular dystrophy (DMD). Ezutromid was found to undergo hepa
Publikováno v:
Synthesis. 50:64-83
Epoxidation of racemic trans -2-(N, N -dibenzylamino)cyclohex-3-en-1-ol, upon treatment with Cl 3 CCO 2 H then m -CPBA, proceeded with poor diastereoselectivity (ca. 60:40 dr), whilst epoxidation of racemic trans -2-(N -benzylamino)cyclohex-3-en-1-ol
Publikováno v:
Tetrahedron. 89:132056
An asymmetric synthesis of microcosamine A, microgrewiapine A and microgrewiapine B (Microcos paniculata alkaloids) is reported. Conjugate addition of lithium (S)-N-benzyl-N-(α-methylbenzyl)amide to tert-butyl crotonate followed by enolate oxidation