Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Ai Kaiho"'
Autor:
Yuki Mori, Yoshino Akizuki, Rikuto Honda, Miyu Takao, Ayaka Tsuchimoto, Sota Hashimoto, Hiroaki Iio, Masakazu Kato, Ai Kaiho-Soma, Yasushi Saeki, Jun Hamazaki, Shigeo Murata, Toshikazu Ushijima, Naoko Hattori, Fumiaki Ohtake
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Targeted protein degradation is a groundbreaking modality in drug discovery; however, the regulatory mechanisms are still not fully understood. Here, we identify cellular signaling pathways that modulate the targeted degradation of the antic
Externí odkaz:
https://doaj.org/article/4f25f96a86114608b7624ec4158746a7
Autor:
Daichi Sadato, Chizuko Hirama, Ai Kaiho-Soma, Ayaka Yamaguchi, Hiroko Kogure, Sonomi Takakuwa, Mina Ogawa, Noriko Doki, Kazuteru Ohashi, Hironori Harada, Keisuke Oboki, Yuka Harada
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0255257 (2021)
Gene abnormalities, including mutations and fusions, are important determinants in the molecular diagnosis of myeloid neoplasms. The use of bone marrow (BM) smears as a source of DNA and RNA for next-generation sequencing (NGS) enables molecular diag
Externí odkaz:
https://doaj.org/article/3173f9b171914b53b197c507cbe2a672
Autor:
Hikaru Tsuchiya, Daocharad Burana, Fumiaki Ohtake, Naoko Arai, Ai Kaiho, Masayuki Komada, Keiji Tanaka, Yasushi Saeki
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Ubiquitylation is a dynamic post-translational modification involved in the regulation of numerous cellular processes. Here the authors describe Ub-ProT: a method to measure the length of substrate-attached ubiquitin chains in biological samples, and
Externí odkaz:
https://doaj.org/article/2b014eb25d6c43bab969807300ebe60e
Autor:
Masayoshi Itoh, Miki Kojima, Sayaka Nagao-Sato, Eri Saijo, Timo Lassmann, Mutsumi Kanamori-Katayama, Ai Kaiho, Marina Lizio, Hideya Kawaji, Piero Carninci, Alistair R R Forrest, Yoshihide Hayashizaki
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30809 (2012)
BackgroundCap analysis of gene expression (CAGE) is a 5' sequence tag technology to globally determine transcriptional starting sites in the genome and their expression levels and has most recently been adapted to the HeliScope single molecule sequen
Externí odkaz:
https://doaj.org/article/812f9b1b98994c8f9777da73842d64fa
Autor:
Mutsumi Kanamori-Katayama, Ai Kaiho, Yuri Ishizu, Yuko Okamura-Oho, Okio Hino, Masaaki Abe, Takumi Kishimoto, Hisahiko Sekihara, Yukio Nakamura, Harukazu Suzuki, Alistair R R Forrest, Yoshihide Hayashizaki
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25391 (2011)
BACKGROUND: Mesothelioma is a highly malignant tumor that is primarily caused by occupational or environmental exposure to asbestos fibers. Despite worldwide restrictions on asbestos usage, further cases are expected as diagnosis is typically 20-40 y
Externí odkaz:
https://doaj.org/article/86f9b3d6cf96493d9ea77b93c0613514
Autor:
Yoshino Akizuki, Mai Morita, Yuki Mori, Ai Kaiho-Soma, Shivani Dixit, Akinori Endo, Marie Shimogawa, Gosuke Hayashi, Mikihiko Naito, Akimitsu Okamoto, Keiji Tanaka, Yasushi Saeki, Fumiaki Ohtake
Publikováno v:
Nature Chemical Biology. 19:311-322
Targeted protein degradation through chemical hijacking of E3 ubiquitin ligases is an emerging concept in precision medicine. The ubiquitin code is a critical determinant of the fate of substrates. Although two E3s, CRL2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf421bd83d488f3135158c321fa1f64
https://doi.org/10.1038/s41589-022-01178-1
https://doi.org/10.1038/s41589-022-01178-1
Autor:
Yifan Huang, Hiroshi Morita, Ai Kaiho-Soma, Fumiaki Ohtake, Yusuke Hirasawa, Kazunori Takahashi, Naoki Kanoh, Hiromasa Yokoe
Publikováno v:
Bioconjugate Chemistry. 33:142-151
Trivalent PROTACs having a functionalization site with controlled orientation were designed, synthesized, and evaluated. Based on the X-ray structure of BRD protein degrader MZ1 (1) in complex with human VHL and BRD4BD2, we expected that the 1,2-disu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5733de9a0c9eb730ed0289be4856b1d4
https://doi.org/10.1021/acs.bioconjchem.1c00490
https://doi.org/10.1021/acs.bioconjchem.1c00490
Autor:
Ai Kaiho-Soma, Chizuko Hirama, Hironori Harada, Daichi Sadato, Mina Ogawa, Noriko Doki, Kazuteru Ohashi, Keisuke Oboki, Sonomi Takakuwa, Hiroko Kogure, Yuka Harada, Ayaka Yamaguchi
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0255257 (2021)
PLoS ONE
PLoS ONE
Gene abnormalities, including mutations and fusions, are important determinants in the molecular diagnosis of myeloid neoplasms. The use of bone marrow (BM) smears as a source of DNA and RNA for next-generation sequencing (NGS) enables molecular diag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62737ea0804d6a3523e9989e07921cfc
https://doaj.org/article/3173f9b171914b53b197c507cbe2a672
https://doaj.org/article/3173f9b171914b53b197c507cbe2a672
Publikováno v:
Genes to Cells
In eukaryotic nuclei, a number of phase‐separated nuclear bodies (NBs) are present. RNA polymerase II (Pol II) is the main player in transcription and forms large condensates in addition to localizing at numerous transcription foci. Cajal bodies (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75e513d4a9ca2407122b7de71f89e3d
https://doi.org/10.1101/2020.12.25.424380
https://doi.org/10.1101/2020.12.25.424380
Autor:
Mikihiko Naito, Keiji Tanaka, Fumiaki Ohtake, Yosuke Demizu, Yoshino Akizuki, Akinori Endo, Ai Kaiho-Soma, Katsuhide Igarashi, Takuji Shoda, Yasushi Saeki, Yasuko Kawase
Publikováno v:
Molecular cell. 81(7)
Targeted protein degradation is an emerging therapeutic paradigm. Small-molecule degraders such as proteolysis-targeting chimeras (PROTACs) induce the degradation of neo-substrates by hijacking E3 ubiquitin ligases. Although ubiquitylation of endogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f801f315ec73bdff7bbac9e4608008f6
https://pubmed.ncbi.nlm.nih.gov/33798411
https://pubmed.ncbi.nlm.nih.gov/33798411