Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Ai J. Lin"'
Autor:
Ai J. Lin, Mara Kreishman-Deitrick, Diana Caridha, Qigui Li, Vasiliy Korotchenko, Lucia Gerena, Philip L. Smith, Ramadas Sathunuru
Publikováno v:
Journal of Medicinal Chemistry. 58:3411-3431
Chloroquine (CQ) has been used as first line malaria therapeutic drug for decades. Emergence of CQ drug-resistant Plasmodium falciparum malaria throughout endemic areas of the world has limited its clinical value. Mefloquine (MQ) has been used as an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76638643c71cd6f60c3180431264c5e
https://doi.org/10.1021/jm501809x
https://doi.org/10.1021/jm501809x
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:1541-1549
A series of new N -alky- and N -alkoxy-imidazolidinediones was prepared and assessed for prophylactic and radical curative activities in mouse and Rhesus monkey models. New compounds are generally metabolically stable, weakly active in vitro against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1af0e53f584f5c63d5488a463cb0061a
https://doi.org/10.1016/j.bmc.2010.12.028
https://doi.org/10.1016/j.bmc.2010.12.028
Publikováno v:
Journal of Heterocyclic Chemistry. 47:1056-1061
Facile methods were developed to prepare a series of 6-phenyl and 6-alkyl-2,4-diaminopyrimidine derivatives. The pyrimidine ring of the final products was constructed by treatment of a 1,3-dicarbonyl derivative with an amidine or guanidine. The 6-phe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5715650989d457d3b326033a1ffa8ae4
https://doi.org/10.1002/jhet.419
https://doi.org/10.1002/jhet.419
Publikováno v:
Journal of Heterocyclic Chemistry. 45:1673-1678
A novel and facile one-pot procedure for the preparation of 2,4-diamino-6-substituted-s-triazine derivatives (IIa-n) was reported. The scope of its application was demonstrated with a number of examples. The new procedure involved treatment of progua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2384f4e1940241277616765287a8d4c
https://doi.org/10.1002/jhet.5570450618
https://doi.org/10.1002/jhet.5570450618
Publikováno v:
Journal of Medicinal Chemistry. 50:889-896
Amodiaquine (AQ) and tebuquine are 4-aminoquinoline antimalarials with Mannich base side chain and are highly effective against chloroquine (CQ)-resistant strains of Plasmodium falciparum. Clinical use of AQ has been severely restricted due to hepato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e35c7bed7eac6652430fc8a52a91a2c4
https://doi.org/10.1021/jm061232x
https://doi.org/10.1021/jm061232x
Publikováno v:
Antimicrobial Agents and Chemotherapy. 50:1649-1655
Tetra-acetamide pyrroloquinazolinediamine (PQD-A4) and bis-ethylcarbamyl pyrroloquinazolinediamine (PQD-BE) are new derivatives of pyrroloquinazolinediamine (PQD) and are being investigated as potential chemotherapeutic agents for the treatment of ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::137359180c9c5564876aef6a1778df95
https://doi.org/10.1128/aac.50.5.1649-1655.2006
https://doi.org/10.1128/aac.50.5.1649-1655.2006
Autor:
Gettayacamin Montip, Jian Guan, Charles A. DiTusa, Donald R. Skillman, Wilbur K. Milhous, Quan Zhang, Ai J. Lin, Jean M. Karle
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:699-704
The reported synthetic procedure of WR182393, a 2-guanidinoimidazolidinedione derivative with high prophylactic antimalarial activity, was found to be a mixture of three closely related products. Poor solubility of WR182393 in both water and organic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b639e55ee981e94e605d659b1616c43b
https://doi.org/10.1016/j.bmc.2004.10.052
https://doi.org/10.1016/j.bmc.2004.10.052
Publikováno v:
Journal of Medicinal Chemistry. 45:3491-3496
A class of new pyrimidinyl peptidomimetic agents (compounds 1-6) were synthesized, and their in vitro antimalarial activities against Plasmodium falciparum were evaluated. The core structure of the new agents consists of a substituted 5-aminopyrimido
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21591aa77a3e52422261591a50f61a48
https://doi.org/10.1021/jm020104f
https://doi.org/10.1021/jm020104f
Publikováno v:
Journal of Medicinal Chemistry. 40:1396-1400
To search for water soluble dihydroartemisinin derivatives with higher efficacy and longer plasma half-life than artesunic or artelinic acid, a series of new stereoisomers of 4-(p-substituted phenyl)-4(R or S)-[10(alpha or beta)-dihydroartemisininoxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf45cdebaa08653374792c40db9cbf8c
https://doi.org/10.1021/jm9607919
https://doi.org/10.1021/jm9607919
Publikováno v:
Pharmaceutical Research. 14:1449-1454
Purpose. To study the reaction of artelinic acid with chemical model systems of cytochrome P-450 as a means of obtaining authentic samples of the putative metabolites necessary for identification of the mammalian metabolites of artelinic acid.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f41046de0ff8133af9370dee586d4185
https://doi.org/10.1023/a:1012185124972
https://doi.org/10.1023/a:1012185124972