Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ai Ikejiri"'
Autor:
Makoto Saito, Yasushi Itoh, Fumihiko Yasui, Tsubasa Munakata, Daisuke Yamane, Makoto Ozawa, Risa Ito, Takayuki Katoh, Hirohito Ishigaki, Misako Nakayama, Shintaro Shichinohe, Kenzaburo Yamaji, Naoki Yamamoto, Ai Ikejiri, Tomoko Honda, Takahiro Sanada, Yoshihiro Sakoda, Hiroshi Kida, Thi Quynh Mai Le, Yoshihiro Kawaoka, Kazumasa Ogasawara, Kyoko Tsukiyama-Kohara, Hiroaki Suga, Michinori Kohara
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Here, the authors report bi-functional, wide tropic macrocycles that bind the influenza viral envelope protein hemagglutinin and inhibit virus infection by blocking adsorption and fusion and show efficacy in preventing severe pneumonia at later stage
Externí odkaz:
https://doaj.org/article/c9870560bd824a40938a1a8131ac4429
Autor:
Yutaka Kurebayashi, Shigenori Nagai, Ai Ikejiri, Masashi Ohtani, Kenji Ichiyama, Yukiko Baba, Taketo Yamada, Shohei Egami, Takayuki Hoshii, Atsushi Hirao, Satoshi Matsuda, Shigeo Koyasu
Publikováno v:
Cell Reports, Vol 34, Iss 12, Pp 108886- (2021)
Externí odkaz:
https://doaj.org/article/c88c1577489349dba6d9710dae095812
Autor:
Yutaka Kurebayashi, Shigenori Nagai, Ai Ikejiri, Masashi Ohtani, Kenji Ichiyama, Yukiko Baba, Taketo Yamada, Shohei Egami, Takayuki Hoshii, Atsushi Hirao, Satoshi Matsuda, Shigeo Koyasu
Publikováno v:
Cell Reports, Vol 1, Iss 4, Pp 360-373 (2012)
The PI3K-Akt-mTORC1 axis contributes to the activation, survival, and proliferation of CD4+ T cells upon stimulation through TCR and CD28. Here, we demonstrate that the suppression of this axis by deletion of p85α or PI3K/mTORC1 inhibitors as well a
Externí odkaz:
https://doaj.org/article/4a99576876914f6a89394ac8677c2a03
Autor:
Risa Ito, Tsubasa Munakata, Tomoko Honda, Shintaro Shichinohe, Kenzaburo Yamaji, Fumihiko Yasui, Michinori Kohara, Takahiro Sanada, Yasushi Itoh, Daisuke Yamane, Makoto Saito, Hiroaki Suga, Makoto Ozawa, Takayuki Katoh, Ai Ikejiri, Yoshihiro Sakoda, Yoshihiro Kawaoka, Kyoko Tsukiyama-Kohara, Misako Nakayama, Kazumasa Ogasawara, Thi Quynh Mai Le, Hiroshi Kida, Naoki Yamamoto, Hirohito Ishigaki
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Most anti-influenza drugs currently used, such as oseltamivir and zanamivir, inhibit the enzymatic activity of neuraminidase. However, neuraminidase inhibitor-resistant viruses have already been identified from various influenza virus isolates. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df0430e276a1f796588ffa8ae002636a
https://doaj.org/article/c9870560bd824a40938a1a8131ac4429
https://doaj.org/article/c9870560bd824a40938a1a8131ac4429
Autor:
Yoshihiro Sakoda, Shintaro Shichinohe, Masahiro Kitabatake, Yukiko Hayashi, Keisuke Munekata, Michinori Kohara, Hiroshi Kida, Ai Ikejiri, Yasushi Itoh, Misako Nakayama, Kazumasa Ogasawara, Hirohito Ishigaki, Fumihiko Yasui, Nobuo Sakaguchi
Publikováno v:
Scientific Reports
H5N1 highly pathogenic avian influenza (H5N1 HPAI) virus causes elevated mortality compared with seasonal influenza viruses like H1N1 pandemic influenza (H1N1 pdm) virus. We identified a mechanism associated with the severe symptoms seen with H5N1 HP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::223ee1904fc7f668a4ba3dbc28595473
https://doi.org/10.1038/srep37915
https://doi.org/10.1038/srep37915
Autor:
Shohei Egami, Ai Ikejiri, Shigeo Koyasu, Kenji Ichiyama, Yukiko Baba, Taketo Yamada, Yutaka Kurebayashi, Masashi Ohtani, Atsushi Hirao, Shigenori Nagai, Satoshi Matsuda, Takayuki Hoshii
Publikováno v:
Cell Reports, Vol 1, Iss 4, Pp 360-373 (2012)
Cell Reports, Vol 34, Iss 12, Pp 108886-(2021)
Cell Reports, Vol 34, Iss 12, Pp 108886-(2021)
SummaryThe PI3K-Akt-mTORC1 axis contributes to the activation, survival, and proliferation of CD4+ T cells upon stimulation through TCR and CD28. Here, we demonstrate that the suppression of this axis by deletion of p85α or PI3K/mTORC1 inhibitors as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1bab885077738f778760573380ea27f
http://www.sciencedirect.com/science/article/pii/S2211124712000642
http://www.sciencedirect.com/science/article/pii/S2211124712000642
Autor:
Shigenori Nagai, Keiyo Takubo, Ai Ikejiri, Nobuhito Goda, Toshio Suda, Yutaka Kurebayashi, Mayuko Osada-Oka, Shigeo Koyasu
Publikováno v:
International Immunology. 24:137-146
Naive CD4(+) T cells are activated by antigen-presenting cells (APCs) and differentiate into distinct types of helper T (T(h)) cells in the lymph node or spleen. Oxygen (O(2)) tension is generally low in these secondary lymphoid tissues compared with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30e47ca751379889ef9cd5558dbabf4
https://doi.org/10.1093/intimm/dxr111
https://doi.org/10.1093/intimm/dxr111
Autor:
Takeshi Haga, Yuya Shimizu, Ai Ikejiri, Tomoyuki Miura, Hironori Miyata, Hidenori Matsui, Shino Kumabe, Li Huang, Yoshitaka Goto
Publikováno v:
Experimental Animals. 55:405-409
The ability of live attenuated Salmonella enterica serovar typhimurium (S. typhimurium) as a carrier of DNA vaccine was evaluated using model plasmid encoding beta-galactosidase (beta-Gal) and BALB/c mice. We constructed pBRCMVbeta, beta-Gal expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b82c599da40b9ccd63b7c62ea5cefdf6
https://doi.org/10.1538/expanim.55.405
https://doi.org/10.1538/expanim.55.405
Publikováno v:
Genes to Cells
IL-17-producing T helper (Th17) cells comprise a distinct Th subset involved in epithelial cell- and neutrophil-mediated immune responses against extracellular microbes. At the same time, Th17 cells play significant roles in the development of autoim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b41f6ef1e712767259d0dd45400070f
https://pubmed.ncbi.nlm.nih.gov/23383714
https://pubmed.ncbi.nlm.nih.gov/23383714
Autor:
Li Huang, Hironori Miyata, Hidenori Tanaka, Takeshi Haga, Kazuyuki Uchida, Ai Ikejiri, Ryo Akashi, Yuya Shimizu, Jun Toyama, Takumi Adachi, Yoshitaka Goto
Publikováno v:
The Journal of veterinary medical science. 70(5)
The aim of this study is to investigate the immunoadjuvant activity of the crude Momordica charantia lectin (crMCL) extracted from seed using beta-galactosidase (beta-gal) as the model antigen. BALB/c mice were injected intramuscularly with beta-gal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058c69d7b89ea0cfe4c741030400e2d2
https://pubmed.ncbi.nlm.nih.gov/18525182
https://pubmed.ncbi.nlm.nih.gov/18525182