Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Ai Bee Ong"'
1
A comparative study of dynamic contrast-enhanced MRI parameters as biomarkers for anti-angiogenic drug therapy
Autor: Septian Hartono, Ai Bee Ong, Tong San Koh, Norita Sukri, Choon Hua Thng, Chuing Ing Wong, Rod A. Humerickhouse, Boon Cher Goh, Ross A. Soo, Helmut Rumpel, Bee Choo Tai, Albert S. C. Low
Publikováno v: NMR in Biomedicine. 24:1169-1180
The aim of the present study was to compare three tracer kinetics methods for the analysis of dynamic contrast-enhanced (DCE) MRI data, namely the generalized kinetics model, the distributed-parameter model and the initial area under the tumor tracer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f173e57a514370da654dbfe050c8435
https://doi.org/10.1002/nbm.1680
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2
Ketoconazole Renders Poor CYP3A Phenotype Status With Midazolam as Probe Drug
Autor: Ai-Bee Ong, Wei Peng Yong, How Sung Lee, Soo-Chin Lee, Boon Cher Goh, Norita Sukri, Ross A. Soo, Lai-San Tham, Lingzhi Wang, Lu Fan
Publikováno v: Therapeutic Drug Monitoring. 28:255-261
Drugs metabolized by cytochrome CYP3A isoenzymes have wide interindividual variability and normally distributed plasma clearance distributions. This makes precise dosing difficult to achieve clinically, which may compromise safe therapy. We hypothesi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea13cb5b3b714cef34081baf1ca7c03a
https://doi.org/10.1097/01.ftd.0000194497.55269.d9
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3
Phenotyping CYP3A using midazolam in cancer and noncancer Asian patients
Autor: Ai Bee Ong, How Sung Lee, Boon Cher Goh, Lu Fan, Robert Lim, Charlotte Chua, Lingzhi Wang, Yok Moi Khoo
Publikováno v: British Journal of Clinical Pharmacology. 55:270-277
Aims To investigate CYP3A activity in cancer and noncancer Asian patients using midazolam and to reveal possible alternative traits for phenotyping CYP3A. Methods Intravenous midazolam 2.5 mg or 2.5–8 mg was administered to 27 cancer and 24 noncanc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6801f582470e7b431745917d9f354095
https://doi.org/10.1046/j.1365-2125.2003.01767.x
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4
Explaining Interindividual Variability of Docetaxel Pharmacokinetics and Pharmacodynamics in Asians Through Phenotyping and Genotyping Strategies
Autor: Soo Chin Lee, Jatinder K. Lamba, Lingzhi Wang, Hong-Liang Lim, Robert Lim, Erin G. Schuetz, How Sung Lee, Jia-Yi Guo, Boon Cher Goh, Lu Fan, Ai-Bee Ong
Publikováno v: Journal of Clinical Oncology. 20:3683-3690
PURPOSE: To explain the variability of docetaxel pharmacokinetics through study of CYP3A phenotype and genotype, and MDR1 genotype. PATIENTS AND METHODS: We studied the pharmacokinetics and pharmacodynamics of docetaxel in patients in whom it was ind
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::564f914eb8c88fe609d6ced767b726e7
https://doi.org/10.1200/jco.2002.01.025
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5
Multi-centre phase II trial of Thalidomide in the treatment of unresectable hepatocellular carcinoma
Autor: Seng Weng Wong, Ai Bee Ong, Robert Lim, Benjamin Chuah, Michael Millward, Stephen Clarke, Boon Cher Goh, Kong Hl, Michael Boyer
Publikováno v: Acta oncologica (Stockholm, Sweden). 46(2)
Hepatocellular carcinoma (HCC) is a hypervascular tumour, which overexpresses vascular endothelial growth factor. Thalidomide is an antiangiogenic agent with activity in refractory multiple myeloma. The purpose of this multi-centre phase II study was
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::849aaac63dc69e08646f1c9e67e8b65e
https://pubmed.ncbi.nlm.nih.gov/17453375
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6
Phenotyping CYP3A using midazolam in cancer and noncancer Asian patients
Autor: How Sung, Lee, Boon Cher, Goh, Lu, Fan, Yok Moi, Khoo, Lingzhi, Wang, Robert, Lim, Ai Bee, Ong, Charlotte, Chua
Publikováno v: British journal of clinical pharmacology. 55(3)
To investigate CYP3A activity in cancer and noncancer Asian patients using midazolam and to reveal possible alternative traits for phenotyping CYP3A.Intravenous midazolam 2.5 mg or 2.5-8 mg was administered to 27 cancer and 24 noncancer patients, res
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6e8a279686183584640a9304e9f48cc7
https://pubmed.ncbi.nlm.nih.gov/12630977
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8
Dynamic contrast enhanced MRI (DCE MRI) for assessment of effects of anti-angiogenic therapy: Comparison of the transfer constant (Ktrans) to blood flow and permeability derived by a distributed parameters model
Autor: Tong San Koh, Choon Hua Thng, Ai-Bee Ong, Boon Cher Goh, Rod A. Humerickhouse, Norita Sukri, James B. K. Khoo, Ross A. Soo, Bee Choo Tai, H. Rumpel
Publikováno v: Journal of Clinical Oncology. 25:14109-14109
14109 Background: Transfer constant (Ktrans) and IAUC60 normalized with arterial input function are commonly used dynamic contrast enhanced magnetic resonance imaging (DCE MRI) parameters. The distributed parameters model (DP) is a DCE MRI model that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::567f47f3bc795d5424b9baf1719f60ce
https://doi.org/10.1200/jco.2007.25.18_suppl.14109
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