Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ai, Okajima"'
Publikováno v:
Healthcare Informatics Research, Vol 30, Iss 4, Pp 355-363 (2024)
Objectives This study evaluated the efficacy of integrating a retrieval-augmented generation (RAG) model and a large language model (LLM) to improve the accuracy of drug name mapping across international vocabularies. Methods Drug ingredient names we
Externí odkaz:
https://doaj.org/article/bb09d319ac0b465196d360b32f52e44c
Autor:
Yoshiko Miura, Saki Ariizumi, Yuri Nishimura, Naoto Oku, Kenneth J. Shea, Ai Okajima, Adam Weisman, Yudai Narita, Yusuke Yonamine, Hiroyuki Koide, Shih Hui Lee, Keiichi Yoshimatsu, Yu Hoshino
Publikováno v:
Nature Chemistry. 9:715-722
Protein affinity reagents are widely used in basic research, diagnostics and separations and for clinical applications, the most common of which are antibodies. However, they often suffer from high cost, and difficulties in their development, product
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb8c93e3c1789eef5d009ef6f1e69205
https://doi.org/10.1038/nchem.2749
https://doi.org/10.1038/nchem.2749
Autor:
Mika Funahashi, Taku Nagai, Koji Yano, Akane Kurachi, Yoko Hibi, Kiyofumi Yamada, Keiko Yamamura, Ai Okajima, Yasuhiro Miyagawa, Noriko Kono, Sakiko Nishikawa
Publikováno v:
Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences). 43:161-168
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68df161afb2530550c7218cdc0da7ae5
https://doi.org/10.5649/jjphcs.43.161
https://doi.org/10.5649/jjphcs.43.161
Autor:
Naoto Oku, Satomi Yamaguchi Ikeuchi, Ai Okajima, Genki Nakamura, Eiichi Muraoka, Kosuke Shimizu
Publikováno v:
Biologicalpharmaceutical bulletin. 41(4)
The tumor microenvironment is one of the key factors contributing to the efficiency of drug delivery to a tumor. It has been reported that lymphangiogenesis is induced in certain tumors. Because the lymphatic system functions as a drainage one, it is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c03a10003f346b6fb6dcb7ba71e63b6b
https://pubmed.ncbi.nlm.nih.gov/29607940
https://pubmed.ncbi.nlm.nih.gov/29607940
Autor:
Hiroyuki, Koide, Keiichi, Yoshimatsu, Yu, Hoshino, Shih-Hui, Lee, Ai, Okajima, Saki, Ariizumi, Yudai, Narita, Yusuke, Yonamine, Adam C, Weisman, Yuri, Nishimura, Naoto, Oku, Yoshiko, Miura, Kenneth J, Shea
Publikováno v:
Nature chemistry. 9(7)
Protein affinity reagents are widely used in basic research, diagnostics and separations and for clinical applications, the most common of which are antibodies. However, they often suffer from high cost, and difficulties in their development, product
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::da7c7c17d7f1b2eb09a1280bd89ae6e2
https://pubmed.ncbi.nlm.nih.gov/28644480
https://pubmed.ncbi.nlm.nih.gov/28644480
Autor:
Ai Okajima, Masataka Date, Yamamoto, Nahoko Ogata, Masanori Matsushita, Kyoichi Inoue, Yoshitsugu Kubota, Kazushige Sakitani, Kayo Shibano, Tadayoshi Okumura, Wallace L. McKeehan, Mikio Kan, Toshihito Seki, Koichi Matsuzaki
Publikováno v:
Journal of Hepatology. 28:572-581
Transforming growth factor-beta (TGF-beta) is a family of multifunctional proteins that regulate hepatocyte proliferation, and biosynthesis of the extracellular matrix. In this study we examined whether modulation of TGF-beta receptor expression cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78907f0f133ebc6f9b280180770f05ba
https://doi.org/10.1016/s0168-8278(98)80280-8
https://doi.org/10.1016/s0168-8278(98)80280-8
Publikováno v:
Hepatology. 25:97-102
Hepatocyte growth factor activator (HGFA) is a serine protease that is responsible for localized activation of hepatocyte growth factor (HGF) in injured tissue. The activated HGF may be involved in regeneration of the injured tissue. HGFA is produced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a166526646596c826e4329bbcff2a0c5
https://doi.org/10.1002/hep.510250118
https://doi.org/10.1002/hep.510250118
Publikováno v:
European Journal of Biochemistry. 213:113-119
Hepatocyte growth factor/scatter factor (HGF/SF) is a potent mitogen for hepatocytes in primary culture. In response to liver damage, the levels of HGF/SF mRNA change in various tissues. In this study, we isolated a genomic DNA fragment containing th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::854b3e81fccc32284f0b0aa86fc84cd0
https://doi.org/10.1111/j.1432-1033.1993.tb17740.x
https://doi.org/10.1111/j.1432-1033.1993.tb17740.x
Publikováno v:
Hepato-gastroenterology. 51(56)
The activation pathway of hepatocyte growth factor (HGF), including HGF activator (HGFA) and HGFA inhibitor-1, 2 (HAI-1, 2), has recently been clarified. The present study examined mRNA expressions of HGF, HGFA and HAI-1 following partial hepatectomy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8ee3f197603c7ebc6af48f954c73b551
https://pubmed.ncbi.nlm.nih.gov/15086199
https://pubmed.ncbi.nlm.nih.gov/15086199
Autor:
Kenji Kuno, Yohji Ueno, Ai Okajima, Yoshitsugu Nakahashi, Kyoichi Inoue, Hiroaki Miyazaki, Yuji Naitoh, Shingo Yanagitani
Publikováno v:
Journal of biochemistry. 124(1)
The induction of metallothionein (MT) isoforms (MT-1, -2) by anticancer drugs was investigated in cultured rat hepatoma H4 II E C3 cells. The steady-state expression of MT-1 mRNAs was higher than that of MT-2 mRNAs. During incubation of the cells wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e33bcc65398d37bb43fb4513c367373
https://pubmed.ncbi.nlm.nih.gov/9644247
https://pubmed.ncbi.nlm.nih.gov/9644247