Increased Lifetime Risk of Intestinal Complications and Extraintestinal Manifestations in Crohn's Disease and Ulcerative Colitis

Autor: Gary R, Lichtenstein, Ahva, Shahabi, Seth A, Seabury, Darius N, Lakdawalla, Oliver Díaz, Espinosa, Sarah, Green, Michelle, Brauer, Robert N, Baldassano

Publikováno v: Gastroenterol Hepatol (N Y)

Patients with Crohn’s disease (CD) or ulcerative colitis (UC) have high morbidity rates owing to debilitating intestinal complications and extraintestinal manifestations (EIMs). We retrospectively identified patients in the Truven MarketScan databa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8ffcd73061650eab81a121e14edb9967
https://pubmed.ncbi.nlm.nih.gov/35505770

The economic burden of switching targeted disease-modifying anti-rheumatic drugs among rheumatoid arthritis patients

Autor: Ahva Shahabi, Tammy Curtice, Jason Shafrin, Alexander Marshall, Damemarie Paul, Lauren Zhao, Sarah Green

Publikováno v: Journal of medical economics. 22(4)

To estimate real world healthcare costs and resource utilization of rheumatoid arthritis (RA) patients associated with targeted disease modifying anti-rheumatic drugs (tDMARD) switching in general and switching to abatacept specifically.RA patients i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::088855eb9fe901e6d4431c34746bd555
https://pubmed.ncbi.nlm.nih.gov/30653389

Novel Gene Expression Signature Predictive of Clinical Recurrence After Radical Prostatectomy in Early Stage Prostate Cancer Patients

Autor: Jie Ren, Jian-Bing Fan, Inderbir S. Gill, Joseph G. Hacia, Siamak Daneshmand, Mariana C. Stern, Ahva Shahabi, Andy Sherrod, Jacek Pinski, Craig April, Juan Pablo Lewinger

Publikováno v: The Prostate. 76:1239-1256

BACKGROUND Current clinical tools have limited accuracy in differentiating patients with localized prostate cancer who are at risk of recurrence from patients with indolent disease. We aimed to identify a gene expression signature that jointly with c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f2724bb5689f51e123472ecc0992453
https://doi.org/10.1002/pros.23211

Lifetime Economic Burden of Crohn's Disease and Ulcerative Colitis by Age at Diagnosis

Autor: Robert N. Baldassano, Gary R. Lichtenstein, Ahva Shahabi, Oliver Díaz Espinosa, Seth A. Seabury, Michelle Brauer, Sarah Green, Darius N. Lakdawalla

Publikováno v: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 18(4)

Background & Aims Understanding the burden of Crohn’s disease (CD) and ulcerative colitis (UC) is important for measuring treatment value. We estimated lifetime health care costs incurred by patients with CD or UC by age at diagnosis. Methods We co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00e9de0df10f5918dd59dec55154997
https://pubmed.ncbi.nlm.nih.gov/31326606

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

Autor: Artitaya Lophatananon, W. Ryan Diver, Stig E. Bojesen, Roman Corral, Fredrick R. Schumacher, Stephen J. Chanock, Shannon K. McDonnell, Graham G. Giles, Craig C. Teerlink, Douglas F. Easton, Cezary Cybulski, Brian E. Henderson, Judith A. Clements, Ali Amin Al Olama, Francois Bacot, David P. Dearnaley, Elio Riboli, Peter Klarskov, Daniel Vincent, Rosemary A. Wilkinson, Danielle M. Karyadi, Michelle Guy, Vincent Khoo, Christopher A. Haiman, Afshan Siddiq, M. Andreas Røder, Amit Joshi, Jong Y. Park, Walther Vogel, Henrik Grönberg, Angela Cox, Rudolf Kaaks, Nora Pashayan, Timothy J. Key, C. R. J. Woodhouse, Jarmo Virtamo, Meredith Yeager, Malgorzata Tymrakiewicz, Sune F. Nielsen, Richard B. Hayes, Johanna Schleutker, Gianluca Severi, Robert Huddart, Wei Zheng, Thomas A. Sellers, Melanie Maranian, Shahana Ahmed, David E. Neal, Daniel Leongamornlert, Zsofia Kote-Jarai, Tiina Wahlfors, Loic Le Marchand, Kay-Tee Khaw, Tokhir Dadaev, Lisa A. Cannon-Albright, Janet L. Stanford, William J. Blot, Andy C. H. Lee, Freddie C. Hamdy, Siqun L. Zheng, Rosalind A. Eeles, Alison M. Dunning, Mariana C. Stern, Melissa C. Southey, Don M. Conroy, Kenneth Muir, Ahva Shahabi, Alan Horwich, Gerald L. Andriole, Antje E. Rinckleb, Srilakshmi Srinivasan, Tim Dudderidge, Joe Dennis, Radka Kaneva, Vanio Mitev, Angela Morgan, Sue A. Ingles, Adam S. Kibel, Markus Aly, Koveela Govindasami, Maya Ghoussaini, Jenny L Donovan, Manuel R. Teixeira, Emma J. Sawyer, Sara Lindström, Jiangfeng Xu, Maren Weischer, Ed Dicks, Jyotsna Batra, S Jugurnauth-Little, Hui-Yi Lin, Suzanne Kolb, Lisa B. Signorello, Dallas R. English, Antonis C. Antoniou, Federico Canzian, Anssi Auvinen, Mia M. Gaudet, Paula Paulo, Paul D.P. Pharoah, Heiko Müller, Qiuyin Cai, Børge G. Nordestgaard, Esther M. John, Sonja I. Berndt, D J Schaid, Daniele Campa, Chris Ogden, Colin Cooper, Craig Luccarini, Jan Lubinski, Elaine A. Ostrander, Ruth C. Travis, Dominika Wokołorczyk, John L. Hopper, Sofia Maia, Sara Benlloch, Chris Parker, Erika M. Kwon, Nicholas van As, Caroline Baynes, C. Slavov, Teuvo L.J. Tammela, Ethan M. Lange, Daniel C. Tessier, David J. Hunter, Dietrich Rothenbacher, Robert A. Stephenson, Liesel M. FitzGerald, Christiane Maier, Hermann Brenner, Kathleen A. Cooney, Graham A. Colditz, Felicity Lose, Edward J. Saunders, Demetrius Albanes, Stephen N. Thibodeau, Fredrik Wiklund, Amanda B. Spurdle, Jan Adolfsson, Susan M. Gapstur, Peter Kraft, Bettina F. Drake, Alan Thompson

Publikováno v: Nature Genetics
Nature Genetics; Vol 45

Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc5d5f82460009b403d064c3a16e687
https://doi.org/10.1038/ng.2560