Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ahrathy Selathurai"'
Autor:
Ahrathy Selathurai, Greg M. Kowalski, Shaun A. Mason, Damien L. Callahan, Victoria C. Foletta, Paul A. Della Gatta, Angus Lindsay, Steven Hamley, Gunveen Kaur, Annie R. Curtis, Micah L. Burch, Teddy Ang, Sean L. McGee, Clinton R. Bruce
Publikováno v:
Molecular Metabolism, Vol 27, Iss , Pp 33-46 (2019)
Objective: Phosphatidylethanolamine (PtdEtn) is a major phospholipid in mammals. It is synthesized via two pathways, the CDP-ethanolamine pathway in the endoplasmic reticulum and the phosphatidylserine (PtdSer) decarboxylase (PSD) pathway in the mito
Externí odkaz:
https://doaj.org/article/014e06075bd9459593a0edd456e20e9c
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e72449 (2013)
BACKGROUND: Dysfunctional lipid metabolism is a hallmark of obesity and insulin resistance and a risk factor for various cardiovascular and metabolic complications. In addition to the well known increase in plasma triglycerides and free fatty acids,
Externí odkaz:
https://doaj.org/article/3db048d0465e417f8462f6dcd800ca20
Autor:
Teddy Ang, Ahrathy Selathurai, Angus Lindsay, Victoria C. Foletta, Gunveen Kaur, Clinton R. Bruce, Sean L. McGee, Micah L Burch, Shaun A. Mason, Steven Hamley, Paul A. Della Gatta, Damien L. Callahan, Grzegorz M Kowalski, Annie R Curtis
Publikováno v:
Molecular Metabolism, Vol 27, Iss, Pp 33-46 (2019)
Molecular Metabolism
Molecular Metabolism
Objective Phosphatidylethanolamine (PtdEtn) is a major phospholipid in mammals. It is synthesized via two pathways, the CDP-ethanolamine pathway in the endoplasmic reticulum and the phosphatidylserine (PtdSer) decarboxylase (PSD) pathway in the mitoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d48d5b907b2317df0cc50f55e04300
http://www.sciencedirect.com/science/article/pii/S2212877819302698
http://www.sciencedirect.com/science/article/pii/S2212877819302698
Publikováno v:
Diabetes. 66:2400-2406
Insulin clamp studies have shown that the suppressive actions of insulin on endogenous glucose production (EGP) are markedly more sensitive than for stimulating glucose disposal (Rd). However, clamp conditions do not adequately mimic postprandial phy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b726696b140f0c7a090ddff405956780
https://doi.org/10.2337/db17-0433
https://doi.org/10.2337/db17-0433
Autor:
Joachim Kloehn, Malcolm J. McConville, Ahrathy Selathurai, Stephanie A.M. Bayol, Séverine Lamon, Robert S. Lee-Young, Matthew J. Watt, Grzegorz M Kowalski, Micah L Burch, Clinton R. Bruce, Steven Hamley
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1851:210-219
Hepatic insulin resistance is a major risk factor for the development of type 2 diabetes and is associated with the accumulation of lipids, including diacylglycerol (DAG), triacylglycerols (TAG) and ceramide. There is evidence that enzymes involved i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803cf39e4e6a9be4431c52fbf4e4acaf
https://doi.org/10.1016/j.bbalip.2014.12.002
https://doi.org/10.1016/j.bbalip.2014.12.002
Autor:
Melissa L. Borg, Alexander Reichenbach, Matthew J. Watt, Zane B. Andrews, Ahrathy Selathurai, Brian J. Oldfield, Moyra B Lemus
Publikováno v:
Diabetes. 63:3647-3658
Neurons within the hypothalamic arcuate nucleus (ARC) are important regulators of energy balance. Recent studies suggest that neurogenesis in the ARC is an important regulator of body mass in response to pharmacological stressors. Regular exercise tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259e9103658259e7bee8529c4701c933
https://doi.org/10.2337/db13-1762
https://doi.org/10.2337/db13-1762
Autor:
Ahrathy Selathurai, Matthew J. Watt, Rachael R Mason, Maria Matzaris, Clinton R. Bruce, Ruzaidi Azli Mohd Mokhtar, Grzegorz M Kowalski, Nancy Mokbel, Peter J. Meikle
Publikováno v:
Molecular Metabolism
Defective control of lipid metabolism leading to lipotoxicity causes insulin resistance in skeletal muscle, a major factor leading to diabetes. Here, we demonstrate that perilipin (PLIN) 5 is required to couple intramyocellular triacylglycerol lipoly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ca94aca88bf8f6cd4daee9509a8ba4
https://doi.org/10.1016/j.molmet.2014.06.002
https://doi.org/10.1016/j.molmet.2014.06.002
Autor:
David P De Souza, Dedreia Tull, Brunda Nijagal, Steven Hamley, Malcolm J. McConville, Clinton R. Bruce, Ahrathy Selathurai, Greg M. Kowalski, Sean O'Callaghan, Joachim Kloehn
Publikováno v:
Scientific Reports
In humans, low-energy diets rapidly reduce hepatic fat and improve/normalise glycemic control. Due to difficulties in obtaining human liver, little is known about changes to the lipid species and pathway fluxes that occur under these conditions. Usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec08b956e98cb127d045503c22809952
Autor:
Greg M. Kowalski, Steve Risis, Clinton R. Bruce, Mark A. Febbraio, Ahrathy Selathurai, Kazuaki Yoshioka, Stuart M. Pitson, Jacquelyn M. Weir, Yoh Takuwa, Christine Yang, Peter J. Meikle, Robert S. Lee-Young, Joanne R Babb
Publikováno v:
Diabetes
The sphingolipids sphingosine-1-phosphate (S1P) and ceramide are important bioactive lipids with many cellular effects. Intracellular ceramide accumulation causes insulin resistance, but sphingosine kinase 1 (SphK1) prevents ceramide accumulation, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7c74cf54915b65b3f81d7fb481d634
https://doi.org/10.2337/db12-0029
https://doi.org/10.2337/db12-0029
Autor:
David P De Souza, Dedreia Tull, Greg M. Kowalski, Clinton R. Bruce, Steve Risis, Joachim Kloehn, Micah L Burch, Malcolm J. McConville, Ahrathy Selathurai, Sean O'Callaghan, Steven Hamley, Robert S. Lee-Young
Publikováno v:
Biochemical and biophysical research communications. 463(4)
Rationale Cardiac metabolism is thought to be altered in insulin resistance and type 2 diabetes (T2D). Our understanding of the regulation of cardiac substrate metabolism and insulin sensitivity has largely been derived from ex vivo preparations whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848cee618f2b12cd0cd1c3fa62d82e03
https://pubmed.ncbi.nlm.nih.gov/26086096
https://pubmed.ncbi.nlm.nih.gov/26086096