Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ahram, Jang"'
Mechanistic patterns and clinical implications of oncogenic tyrosine kinase fusions in human cancers
Autor:
Taek-Chin Cheong, Ahram Jang, Qi Wang, Giulia C. Leonardi, Biagio Ricciuti, Joao V. Alessi, Alessandro Di Federico, Mark M. Awad, Maria K. Lehtinen, Marian H. Harris, Roberto Chiarle
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Tyrosine kinase (TK) fusions are frequently found in cancers, either as initiating events or as a mechanism of resistance to targeted therapy. Partner genes and exons in most TK fusions are followed typical recurrent patterns, but the underl
Externí odkaz:
https://doaj.org/article/f91a851ffb1747f5bdae9ea30cb198bb
Autor:
Ahram Jang, Maria K. Lehtinen
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-15 (2022)
Abstract Choroid plexus (ChP) epithelial cells are crucial for the function of the blood-cerebrospinal fluid barrier (BCSFB) in the developing and mature brain. The ChP is considered the primary source and regulator of CSF, secreting many important f
Externí odkaz:
https://doaj.org/article/db765aad283a4e85bc7ef0bacec82486
Autor:
Ahram Jang, Maria K. Lehtinen
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 101975- (2023)
Summary: Experimentally targeting mouse choroid plexus (ChP) provides a valuable approach for investigating mechanisms of ChP-cerebrospinal fluid (CSF) biology. Here, we provide a protocol to deliver adeno-associated viral vectors (AAVs) by in utero
Externí odkaz:
https://doaj.org/article/876a4ac0e725412cb4e7960c57199433
Autor:
Ahram Jang, Maria K. Lehtinen
Publikováno v:
STAR protocols. 4(1)
Experimentally targeting mouse choroid plexus (ChP) provides a valuable approach for investigating mechanisms of ChP-cerebrospinal fluid (CSF) biology. Here, we provide a protocol to deliver adeno-associated viral vectors (AAVs) by in utero intracere
Autor:
Taek-Chin Cheong, Ahram Jang, Qi Wang, Giulia C. Leonardi, Maria K. Lehtinen, Marian H. Harris, Roberto Chiarle
Publikováno v:
Cancer Research. 83:313-313
Introduction: Tyrosine kinase (TK) fusions are common events in the development of resistance to targeted therapy for non-small cell lung cancer (NSCLC) and others. The mechanisms by which recurrent breakpoints are generated in solid tumors and by wh
Autor:
Karol Kaiser, Ahram Jang, Petra Kompanikova, Melody P. Lun, Jan Prochazka, Ondrej Machon, Neil Dani, Michaela Prochazkova, Benoit Laurent, Daniel Gyllborg, Renee van Amerongen, Ryann M. Fame, Suhasini Gupta, Feizhen Wu, Roger A. Barker, Ivana Bukova, Radislav Sedlacek, Zbynek Kozmik, Ernest Arenas, Maria K. Lehtinen, Vitezslav Bryja
Publikováno v:
Development
The choroid plexus (ChP) produces cerebrospinal fluid and forms an essential brain barrier. ChP tissues form in each brain ventricle, each one adopting a distinct shape, but remarkably little is known about the mechanisms underlying ChP development.
Autor:
Ahram, Jang, Boryana, Petrova, Taek-Chin, Cheong, Miriam E, Zawadzki, Jill K, Jones, Andrew J, Culhane, Frederick B, Shipley, Roberto, Chiarle, Eric T, Wong, Naama, Kanarek, Maria K, Lehtinen
Publikováno v:
Neuron. 110:3288-3301.e8
For many cancer patients, chemotherapy produces untreatable life-long neurologic effects termed chemotherapy-related cognitive impairment (CRCI). We discovered that the chemotherapy methotrexate (MTX) adversely affects oxidative metabolism of non-can
Autor:
Vitezslav Bryja, Ivana Bukova, Zbynek Kozmik, Ahram Jang, Daniel Gyllborg, Ernest Arenas, Karol Kaiser, Ryann M. Fame, Renée van Amerongen, Radislav Sedlacek, Neil Dani, Ondrej Machon, Michaela Prochazkova, Feizhen Wu, Suhasini Gupta, Roger A. Barker, Petra Kompanikova, Melody P. Lun, Benoit Laurent, Maria K. Lehtinen, Jan Prochazka
Publikováno v:
Development. 148
The choroid plexus (ChP) produces cerebrospinal fluid and forms an essential brain barrier. ChP tissues form in each brain ventricle, each one adopting a distinct shape, but remarkably little is known about the mechanisms underlying ChP development.
Autor:
Karol Kaiser, Renée van Amerongen, Ernest Arenas, Zbynek Kozmik, Ivana Uramova, Petra Kompanikova, Jan Prochazka, Michaela Prochazkova, Ondrej Machon, Roger A. Barker, Radislav Sedlacek, Melody P. Lun, Maria K. Lehtinen, Benoit Laurent, Ahram Jang, Vitezslav Bryja, Daniel Gyllborg, Feizhen Wu
The choroid plexus (ChP) produces cerebrospinal fluid and forms a critical barrier between the brain and the circulation. While the ChP forms in each brain ventricle, it adopts a different shape in each one and remarkably little is known about the me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5fe8015214ad5987669c8d706d2ed1
https://doi.org/10.1101/2020.05.07.082370
https://doi.org/10.1101/2020.05.07.082370
Autor:
Danielle Dionne, Lan Nguyen, Maria K. Lehtinen, Cristin McCabe, Samantha J. Riesenfeld, Christopher Rodman, Vitezslav Bryja, Jin Cui, Gilad Green, Jan Prochazka, Karol Kaiser, Orit Rozenblatt-Rosen, Aviv Regev, Neil Dani, Naomi Habib, Joshua P. Head, Ahram Jang, Michaela Prochazkova, Feng Zhang, Rebecca H. Herbst, Radislav Sedlacek, Frederick B. Shipley
Publikováno v:
Cell
The choroid plexus (ChP), located in each brain ventricle, produces cerebrospinal fluid (CSF) and forms the blood-CSF barrier, but is under-characterized. Here, we combine single cell RNA-Seq and spatial mapping of RNA and proteins to construct an at