Structure-activity relationship studies of Imidazo[1',2':1,6]pyrido[2,3-d]pyrimidine derivatives to develop selective FGFR inhibitors as anticancer agents for FGF19-overexpressed hepatocellular carcinoma.

Autor: Kim J; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, South Korea; Department of Drug Discovery, Hanmi Research Center, Hanmi Pharm. Co. Ltd., Gyeonggi-do, 18469, South Korea., Jung SH; Department of Drug Discovery, Hanmi Research Center, Hanmi Pharm. Co. Ltd., Gyeonggi-do, 18469, South Korea., Lee JC; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, South Korea., Kim WJ; Department of Drug Discovery, Hanmi Research Center, Hanmi Pharm. Co. Ltd., Gyeonggi-do, 18469, South Korea., Byun J; Department of Drug Discovery, Hanmi Research Center, Hanmi Pharm. Co. Ltd., Gyeonggi-do, 18469, South Korea., Ahn YG; Department of Drug Discovery, Hanmi Research Center, Hanmi Pharm. Co. Ltd., Gyeonggi-do, 18469, South Korea., Park HJ; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, South Korea. Electronic address: hyunju85@skku.edu.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2025 Jan 15; Vol. 282, pp. 117047. Date of Electronic Publication: 2024 Nov 12.

Statistical comparison for assessing agreement between two mass spectrometric methods for the analysis of polychlorinated dibenzo-p-dioxins and furans (PCDDs/Fs) in contaminated soils.

Autor: Jo J; Department of Environmental Science & Engineering, Ewha Womans University, Seoul, 03760, South Korea., Son Y; Department of Environmental Engineering, Kumoh National Institute of Technology, Gumi, 39177, South Korea; Department of Energy Engineering Convergence, Kumoh National Institute of Technology, 39177, South Korea., Park MK; Department of Environmental Engineering, Jeju National University, 63243, South Korea., Lee JY; Department of Environmental Science & Engineering, Ewha Womans University, Seoul, 03760, South Korea., Chu H; Metropolitan Seoul Center, Korea Basic Science Institute, University-Industry Cooperation Building, 150, Bugahyeon-ro, Seodaemun-gu, Seoul, 03759, South Korea., Ahn YG; Metropolitan Seoul Center, Korea Basic Science Institute, University-Industry Cooperation Building, 150, Bugahyeon-ro, Seodaemun-gu, Seoul, 03759, South Korea. Electronic address: ygahn@kbsi.re.kr.

Publikováno v: Chemosphere [Chemosphere] 2024 Sep; Vol. 363, pp. 142806. Date of Electronic Publication: 2024 Jul 08.

Design and synthesis of 4th generation EGFR inhibitors against human triple (Del19/T790M/C797S) mutation.

Autor: Jeon J; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea; Hanmi Research Center, Hanmi Pharmaceutical Co., Ltd., Hwaseong, 18469, Republic of Korea., Jang SY; Hanmi Research Center, Hanmi Pharmaceutical Co., Ltd., Hwaseong, 18469, Republic of Korea., Kwak EJ; Hanmi Research Center, Hanmi Pharmaceutical Co., Ltd., Hwaseong, 18469, Republic of Korea., Lee SH; Hanmi Research Center, Hanmi Pharmaceutical Co., Ltd., Hwaseong, 18469, Republic of Korea., Byun JY; Hanmi Research Center, Hanmi Pharmaceutical Co., Ltd., Hwaseong, 18469, Republic of Korea., Kim YY; Hanmi Research Center, Hanmi Pharmaceutical Co., Ltd., Hwaseong, 18469, Republic of Korea., Ahn YG; Hanmi Research Center, Hanmi Pharmaceutical Co., Ltd., Hwaseong, 18469, Republic of Korea., Singh P; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea., Moon K; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea., Kim IS; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea. Electronic address: insukim@skku.edu.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2023 Dec 05; Vol. 261, pp. 115840. Date of Electronic Publication: 2023 Sep 27.

Belvarafenib penetrates the BBB and shows potent antitumor activity in a murine melanoma brain metastasis model.

Autor: Kim YY; Hanmi Research Center, Hanmi Pharm. Co. Ltd, Gyeonggi-Do, Korea., Park H; Hanmi Research Center, Hanmi Pharm. Co. Ltd, Gyeonggi-Do, Korea., Song T; Hanmi Research Center, Hanmi Pharm. Co. Ltd, Gyeonggi-Do, Korea., Choi K; Hanmi Research Center, Hanmi Pharm. Co. Ltd, Gyeonggi-Do, Korea., Dolton M; Genentech Inc, South San Francisco, CA, USA., Mao J; Genentech Inc, South San Francisco, CA, USA., Kim J; Hanmi Research Center, Hanmi Pharm. Co. Ltd, Gyeonggi-Do, Korea., Ahn YG; Hanmi Research Center, Hanmi Pharm. Co. Ltd, Gyeonggi-Do, Korea., Suh KH; Hanmi Research Center, Hanmi Pharm. Co. Ltd, Gyeonggi-Do, Korea., Kim YH; Hanmi Research Center, Hanmi Pharm. Co. Ltd, Gyeonggi-Do, Korea. yhkeem@hanmi.co.kr.

Publikováno v: Clinical & experimental metastasis [Clin Exp Metastasis] 2023 Apr; Vol. 40 (2), pp. 137-148. Date of Electronic Publication: 2023 Feb 10.

Gas chromatography-triple quadrupole mass spectrometry as a cost-effective method for the determination of polychlorinated dibenzo-p-dioxins and furans in contaminated soils.

Autor: Jo J; Department of Environmental Science and Engineering, Ewha Womans University, Seoul, 03760, South Korea., Son Y; Department of Environmental Engineering, Kumoh National Institute of Technology, Gumi, 39177, South Korea; Department of Energy Engineering Convergence, Kumoh National Institute of Technology, 39177, South Korea., Lee J; Department of Environmental Science and Engineering, Ewha Womans University, Seoul, 03760, South Korea., Lee D; Department of Environmental Engineering, Kumoh National Institute of Technology, Gumi, 39177, South Korea; Department of Energy Engineering Convergence, Kumoh National Institute of Technology, 39177, South Korea., Shin JH; Seoul Center, Korea Basic Science Institute, Seoul, 02841, South Korea., Ahn YG; Western Seoul Center, Korea Basic Science Institute, University-Industry Cooperation Building, 150, Bugahyeon-ro, Seodaemun-gu, Seoul, 03759, South Korea. Electronic address: ygahn@kbsi.re.kr.

Publikováno v: Chemosphere [Chemosphere] 2022 Dec; Vol. 308 (Pt 2), pp. 136286. Date of Electronic Publication: 2022 Sep 05.