Antiobesity effects of coumestrol through expansion and activation of brown adipose tissue metabolism

Autor: Kim, Sang-Nam, Ahn, Sang-Yeop, Song, Hyun-Doo, Kwon, Hyun-Jung, Saha, Abhirup, Son, Yeonho, Cho, Yoon Keun, Jung, Young-Suk, Jeong, Hyun Woo, Lee, Yun-Hee

Publikováno v: In The Journal of Nutritional Biochemistry February 2020 76

Structural Modification and Biological Evaluation of 2,8-Disubstituted Adenine and Its Nucleosides as A2AAdenosine Receptor Antagonists: Exploring the Roles of Ribose at Adenosine Receptors

Autor: Kim, Gibae, Jarhad, Dnyandev B., Lee, Grim, Kim, Gyudong, Hou, Xiyan, Yu, Jinha, Lee, Chang Soo, Warnick, Eugene, Gao, Zhan-Guo, Ahn, Sang Yeop, Kwak, Dongik, Park, Kichul, Lee, Summer Dabin, Park, Tae-uk, Jung, So-young, Lee, Jong Hyun, Choi, Jong-Ryoul, Kim, Myeongjoong, Kim, Donghyun, Kim, Bongtae, Jacobson, Kenneth A., Jeong, Lak Shin

Publikováno v: Journal of Medicinal Chemistry; June 2024, Vol. 67 Issue: 12 p10490-10507, 18p

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Structural Modification and Biological Evaluation of 2,8-Disubstituted Adenine and Its Nucleosides as A 2A Adenosine Receptor Antagonists: Exploring the Roles of Ribose at Adenosine Receptors.

Autor: Kim G; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Jarhad DB; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Lee G; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Kim G; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; College of Pharmacy & Research Institute of Drug Development, Chonnam National University, Gwangju 61186, Republic of Korea., Hou X; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; College of Life Science, Dalian Minzu University, Dalian 116600, People's Republic of China., Yu J; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea., Lee CS; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Warnick E; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes, and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland 20892, United States., Gao ZG; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes, and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland 20892, United States., Ahn SY; Future Medicine Co., Ltd., 54 Changup-ro, Sujeong-gu, Seongnam, Gyeonggi-do 13449, Republic of Korea., Kwak D; Future Medicine Co., Ltd., 54 Changup-ro, Sujeong-gu, Seongnam, Gyeonggi-do 13449, Republic of Korea., Park K; LNPsolution, R&D Laboratory, 32 Dongguk-ro, Ilsandong-gu, Goyang, Gyeonggi-do 10326, Republic of Korea., Lee SD; LNPsolution, R&D Laboratory, 32 Dongguk-ro, Ilsandong-gu, Goyang, Gyeonggi-do 10326, Republic of Korea., Park TU; Preclincial Research Center (PRC), Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDI hub), Daegu 41061, Republic of Korea., Jung SY; Preclincial Research Center (PRC), Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDI hub), Daegu 41061, Republic of Korea., Lee JH; HK inno.N Corp., Seoul 04551, Republic of Korea., Choi JR; HK inno.N Corp., Seoul 04551, Republic of Korea., Kim M; HK inno.N Corp., Seoul 04551, Republic of Korea., Kim D; HK inno.N Corp., Seoul 04551, Republic of Korea., Kim B; HK inno.N Corp., Seoul 04551, Republic of Korea., Jacobson KA; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes, and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland 20892, United States., Jeong LS; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Future Medicine Co., Ltd., 54 Changup-ro, Sujeong-gu, Seongnam, Gyeonggi-do 13449, Republic of Korea.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Jun 27; Vol. 67 (12), pp. 10490-10507. Date of Electronic Publication: 2024 Jun 06.