Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Ahmet Dirim Arslan"'
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78780 (2013)
Chronic myeloid leukemia (CML) and Ph+ acute lymphoblastic leukemia (ALL) are characterized by the presence of the BCR-ABL oncoprotein, which leads to activation of a plethora of pro-mitogenic and pro-survival pathways, including the mTOR signaling c
Externí odkaz:
https://doaj.org/article/24052efa13034cfc8650dcc815e472d7
Autor:
Leonidas C. Platanias, C. David James, Ramana V. Davuluri, Craig Horbinski, Ichiro Nakano, Shi-Yuan Cheng, Stewart Goldman, Angel A. Alvarez, Jessica Clymer, Ahmet Dirim Arslan, Yingtao Bi, Hridi Hussain, Lisa P. Magnusson, Kristen Alley, Frank D. Eckerdt, Jonathan B. Bell
Supplementary materials and methods for ALDEFLUOR assay and CD44 staining and data showing that patient-derived GSCs are enriched for ALDH+ cells and express CD44.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785a01ca791720334b4a42e4cfc7aca6
https://doi.org/10.1158/1541-7786.22514899
https://doi.org/10.1158/1541-7786.22514899
Autor:
Olga Frankfurt, Gavin T. Blyth, Connor Lantz, Eleanor N. Fish, Leonidas C. Platanias, Ahmet Dirim Arslan, Mariafausta Fischietti, Elspeth M. Beauchamp, Young Ah Goo, Elizabeth A. Eklund, Jessica K. Altman, Paul M. Thomas, Angela Yang, Imo Akpan, Sameem Abedin, Alissa Nelson, Sara G. Radecki
Publikováno v:
Blood. 133:1171-1185
Aberrant activation of mTOR signaling in acute myeloid leukemia (AML) results in a survival advantage that promotes the malignant phenotype. To improve our understanding of factors that contribute to mammalian target of rapamycin (mTOR) signaling act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d5a0c39cc3ff71bff2a8c52ea01bc84
https://doi.org/10.1182/blood-2018-08-870089
https://doi.org/10.1182/blood-2018-08-870089
Autor:
Ahmet Dirim Arslan, Antonella Sassano, Mariafausta Fischietti, Diana Saleiro, Pawel Lisowski, Ewa M. Kosciuczuk, Leonidas C. Platanias, Eleanor N. Fish, Frank Eckerdt
Publikováno v:
Oncogene
We provide evidence that the IFN-regulated member of the Schlafen (SLFN) family of proteins, SLFN5, promotes the malignant phenotype in glioblastoma multiforme (GBM). Our studies indicate that SLFN5 expression promotes motility and invasiveness of GB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be0a95591abbb6162687569b2f8c3d9a
https://doi.org/10.1038/onc.2017.205
https://doi.org/10.1038/onc.2017.205
Autor:
Kazumi Ebine, Christina R. Chow, Krishan Kumar, Benjamin Kwok, Ahmet Dirim Arslan, Frank Eckerdt, Hidayatullah G. Munshi, Leonidas C. Platanias, David J. Bentrem
Publikováno v:
Molecular Cancer Research. 14:216-227
Human pancreatic ductal adenocarcinoma (PDAC) tumors are associated with dysregulation of mRNA translation. In this report, it is demonstrated that PDAC cells grown in collagen exhibit increased activation of the MAPK-interacting protein kinases (MNK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96be7f8b1d50ce273316490a457b27e
https://doi.org/10.1158/1541-7786.mcr-15-0285
https://doi.org/10.1158/1541-7786.mcr-15-0285
Autor:
Bo Hu, Asneha Iqbal, Angel Alvarez, Jonathan B. Bell, Ahmet Dirim Arslan, Stewart Goldman, Shi Yuan Cheng, Frank Eckerdt, Constadina Arvanitis, Leonidas C. Platanias
Publikováno v:
BioTechniques. 60:43-46
Tumor spheroids are becoming an important tool for the investigation of cancer stem cell (CSC) function in tumors; thus, low-cost and high-throughput methods for drug screening of tumor spheroids are needed. Using neurospheres as non-adherent three-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f8c90e4359b3da678de2b0a47b3419
https://doi.org/10.2144/000114372
https://doi.org/10.2144/000114372
Autor:
Ewa M. Kosciuczuk, Zofia Warminska, Eleanor N. Fish, Diana Saleiro, Barbara Kroczynska, Leonidas C. Platanias, Swarna Mehrotra, Gavin T. Blyth, Jacek Jemielity, Robert L. Rafidi, Ahmet Dirim Arslan, Beata Majchrzak-Kita
Publikováno v:
Journal of Biological Chemistry. 291:2389-2396
We provide evidence for a unique pathway engaged by the type II IFN receptor, involving mTORC2/AKT-mediated downstream regulation of mTORC1 and effectors. These events are required for formation of the eukaryotic translation initiation factor 4F comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::527b5fd54063d55be496e6d513645503
https://doi.org/10.1074/jbc.m115.664995
https://doi.org/10.1074/jbc.m115.664995
Autor:
Mariafausta Fischietti, Eleanor N. Fish, Patrick A. Ozark, Gavin T. Blyth, Leonidas C. Platanias, Neha K. Reddy, Diana Saleiro, Roger J. Davis, Curt M. Horvath, Ewa M. Kosciuczuk, Beata Majchrzak-Kita, Ahmet Dirim Arslan
Publikováno v:
Science signaling. 11(557)
It is well established that activation of the transcription factor signal transducer and activator of transcription 1 (STAT1) is required for the interferon-γ (IFN-γ)-mediated antiviral response. Here, we found that IFN-γ receptor stimulation also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca93b578c7f9f09b01855f1ecff62b56
https://pubmed.ncbi.nlm.nih.gov/30459284
https://pubmed.ncbi.nlm.nih.gov/30459284
Autor:
Eleanor N. Fish, Ahmet Dirim Arslan, Mariafausta Fischietti, Antonella Sassano, Beata Majchrzak-Kita, Diana Saleiro, Hidayatullah G. Munshi, Kazumi Ebine, Leonidas C. Platanias
Publikováno v:
Molecular and cellular biology. 38(16)
Although members of the Slfn family have been implicated in the regulation of type I interferon (IFN) responses, the mechanisms by which they mediate their effects remain unknown. In the present study, we provide evidence that targeted disruption of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e498a94caa671c4875936e3aff86d22
https://pubmed.ncbi.nlm.nih.gov/29866656
https://pubmed.ncbi.nlm.nih.gov/29866656
Autor:
Nicholas J. Donato, Leonidas C. Platanias, Francis J. Giles, Gavin T. Blyth, Elspeth M. Beauchamp, Ahmet Dirim Arslan, Dany A. Curi, Jessica K. Altman
Publikováno v:
Oncotarget
We investigated the efficacy of targeting the PIM kinase pathway in Philadelphia chromosome-positive (Ph+) leukemias. We provide evidence that inhibition of PIM, with the pan-PIM inhibitor SGI-1776, results in suppression of classic PIM effectors and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec25fd4704dc1029b7d0b490ff7ceba
http://europepmc.org/articles/PMC4741759
http://europepmc.org/articles/PMC4741759