Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Ahmet Bakan"'
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 9, p e1002705 (2012)
Catalytic loop motions facilitate substrate recognition and binding in many enzymes. While these motions appear to be highly flexible, their functional significance suggests that structure-encoded preferences may play a role in selecting particular m
Externí odkaz:
https://doaj.org/article/3196629757074ffb9aee626a0bfc5df0
Publikováno v:
Structural Biology in Drug Discovery
Publikováno v:
Molecular Pharmacology. 88:421-427
Cytochrome c (cyt c) release from mitochondria is accepted to be the point of no return for eliciting a cascade of interactions that lead to apoptosis. A strategy for containing sustained apoptosis is to reduce the mitochondrial permeability pore ope
Autor:
William J. McCarty, Abhinav Bhushan, Tong Ying Shun, Ahmet Bakan, Rohit Jindal, Shyam Sundhar Bale, Richard DeBiasio, D. Lansing Taylor, Lawrence Vernetti, Albert Gough, Berk Osman Usta, Inna Golberg, Martin L. Yarmush, Nina Senutovitch, Manjunath Hegde
Publikováno v:
Experimental Biology and Medicine. 239:1180-1191
The liver is a heterogeneous organ with many vital functions, including metabolism of pharmaceutical drugs and is highly susceptible to injury from these substances. The etiology of drug-induced liver disease is still debated although generally regar
Publikováno v:
Expert Opinion on Investigational Drugs. 23:661-673
Protein tyrosine (Tyr) phosphatases have been implicated in many diseases, most notably in cancer. While there are a significant number of clinically approved inhibitors of protein Tyr kinases, there are no drugs specifically targeting protein Tyr ph
Publikováno v:
Protein Science. 20:1645-1658
Modeling protein flexibility constitutes a major challenge in accurate prediction of protein–ligand and protein–protein interactions in docking simulations. The lack of a reliable method for predicting the conformational changes relevant to subst
Autor:
Gabriela Mustata, Ahmet Bakan, Mei Li, Michael W. Epperly, Ivet Bahar, Lin Zhang, Joel S. Greenberger, Nicki Zevola, Jian Yu
Publikováno v:
Current Topics in Medicinal Chemistry. 11:281-290
PUMA (p53 upregulated modulator of apoptosis) is a Bcl-2 homology 3 (BH3)-only Bcl-2 family member and a key mediator of apoptosis induced by a wide variety of stimuli. PUMA is particularly important in initiating radiation-induced apoptosis and dama
Publikováno v:
Chemical Reviews. 110:1463-1497
1.1. Protein Dynamics and Allostery 1.1.1. Dynamic Equilibrium between Pre-existing Conformations The ability of macromolecules to sample an ensemble of conformations has been evident for decades, starting from the statistical mechanical theory and s
Autor:
Billy W. Day, Gabriela Molina, Michael Tsang, Ivet Bahar, Ahmet Bakan, Weixiang Dai, Wade Znosko, Thomas E. Smithgall, Andreas Vogt, Pierre E. Queiroz de Oliveira, John S. Lazo
Publikováno v:
Nature chemical biology
The dual-specificity phosphatase 6 (Dusp6) functions as a feedback regulator of fibroblast growth factor (FGF) signaling to limit the activity of extracellular signal-regulated kinases (ERKs) 1 and 2. We have identified a small-molecule inhibitor of
Autor:
Ahmet Bakan, Fumito Koizumi, Kay M. Brummond, John J. Skoko, John S. Lazo, Archibong E. Yellow-Duke, Stefan Werner, Ivet Bahar, Branko Mitasev
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 322:940-947
Mitogen-activated protein kinase phosphatase 1 (MKP-1) is a tyrosine phosphatase superfamily member that dephosphorylates and inactivates cardinal mitogen-activated protein kinase (MAPK) substrates, such as p38, c-Jun NH(2)-terminal kinase, and extra