Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Ahmet Acar"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Metronomic chemotherapy (MCT), characterized by the continuous administration of chemotherapeutics at a lower dose without prolonged drug-free periods, has garnered significant attention over the last 2 decades. Extensive evidence from both pre-clini
Externí odkaz:
https://doaj.org/article/73f4982b4c4148ce8c01a2e210ab940e
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Drug insensitivity is arguably one of the biggest challenges in cancer therapeutics. Although effective therapeutic solutions in cancer are limited due to the emergence of drug insensitivity, exploiting evolutionary understanding in this con
Externí odkaz:
https://doaj.org/article/656178e95b814c298ef31650598aab88
Autor:
Mehmet Arda Temena, Ahmet Acar
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Besides typical respiratory symptoms, COVID-19 patients also have gastrointestinal symptoms. Studies focusing on the gastrointestinal tumors derived from gastrointestinal tissues have raised a question whether these tumors might express high
Externí odkaz:
https://doaj.org/article/c28b182b27e044ccb743c206f1d703cf
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: One of the most significant challenges impeding cancer treatment effectiveness is drug resistance. Combining evolutionary understanding with drug resistance can pave the way for the identification of second-line drug options that can over
Externí odkaz:
https://doaj.org/article/69f1e2ed76ba4ac8a138bb1b195e4b78
Autor:
Subhamay Adhikary, Surajit Pathak, Vignesh Palani, Ahmet Acar, Antara Banerjee, Nader I. Al-Dewik, Musthafa Mohamed Essa, Sawsan G. A. A. Mohammed, M. Walid Qoronfleh
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 217 (2024)
Immunotherapy is now established as a potent therapeutic paradigm engendering antitumor immune response against a wide range of malignancies and other diseases by modulating the immune system either through the stimulation or suppression of immune co
Externí odkaz:
https://doaj.org/article/91b3dd543863490eb6fc38bcc4f745b1
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/01f7d4fc529c41188e716fb0dff2ad73
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0291942 (2023)
Complex evolutionary dynamics governing the drug resistance is one of the major challenges in cancer treatment. Understanding these mechanisms requires a sequencing technology with higher resolution to delineate whether pre-existing or de novo drug m
Externí odkaz:
https://doaj.org/article/b120d0ee37a34d2aa1eccb02edc11945
Autor:
Ahmet Acar, Ana Hidalgo-Sastre, Michael K. Leverentz, Christopher G. Mills, Simon Woodcock, Martin Baron, Giovanna M. Collu, Keith Brennan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Notch and Wnt are two essential signalling pathways that help to shape animals during development and to sustain adult tissue homeostasis. Although they are often active at the same time within a tissue, they typically have opposing effects
Externí odkaz:
https://doaj.org/article/3b960ed61ced47819d25ef2b2656f61c
Autor:
Ahmet Acar, Daniel Nichol, Javier Fernandez-Mateos, George D. Cresswell, Iros Barozzi, Sung Pil Hong, Nicholas Trahearn, Inmaculada Spiteri, Mark Stubbs, Rosemary Burke, Adam Stewart, Giulio Caravagna, Benjamin Werner, Georgios Vlachogiannis, Carlo C. Maley, Luca Magnani, Nicola Valeri, Udai Banerji, Andrea Sottoriva
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Evolutionary steering uses therapies to control tumour evolution by exploiting trade-offs. Here, using a barcoding approach applied to large cell populations, the authors explore evolutionary steering in lung cancer cells treated with EGFR inhibitors
Externí odkaz:
https://doaj.org/article/7266ff52e4984f1da8cfe86c3ba11937
Autor:
Bruno M. Simões, Ciara S. O’Brien, Rachel Eyre, Andreia Silva, Ling Yu, Aida Sarmiento-Castro, Denis G. Alférez, Kath Spence, Angélica Santiago-Gómez, Francesca Chemi, Ahmet Acar, Ashu Gandhi, Anthony Howell, Keith Brennan, Lisa Rydén, Stefania Catalano, Sebastiano Andó, Julia Gee, Ahmet Ucar, Andrew H. Sims, Elisabetta Marangoni, Gillian Farnie, Göran Landberg, Sacha J. Howell, Robert B. Clarke
Publikováno v:
Cell Reports, Vol 12, Iss 12, Pp 1968-1977 (2015)
Breast cancers (BCs) typically express estrogen receptors (ERs) but frequently exhibit de novo or acquired resistance to hormonal therapies. Here, we show that short-term treatment with the anti-estrogens tamoxifen or fulvestrant decrease cell prolif
Externí odkaz:
https://doaj.org/article/4e3f3b9ddd9b4156ad6b16efe17dc30a