Multimodal Probes: Superresolution and Transmission Electron Microscopy Imaging of Mitochondria, and Oxygen Mapping of Cells, Using Small-Molecule Ir(III) Luminescent Complexes

Autor: Luke K. McKenzie, Stanley W. Botchway, Michael D. Ward, Ahmet J. Cankut, Julia A. Weinstein, Jonathan R. Shewring, Elizabeth Edwards, Bethany J. Crowston

Publikováno v: Inorganic Chemistry. 56:15259-15270

We describe an Ir(III)-based small-molecule, multimodal probe for use in both light and electron microscopy. The direct correlation of data between light- and electron-microscopy-based imaging to investigate cellular processes at the ultrastructure l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87738e2bc8c156113713e97b8495eb29
https://doi.org/10.1021/acs.inorgchem.7b02633

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Sensitisation of Eu(III)- and Tb(III)-based luminescence by Ir(III) units in Ir/lanthanide dyads: evidence for parallel energy-transfer and electron-transfer based mechanisms

Autor: Simon C. Parker, Andrew Stephenson, Daniel Sykes, Steven J. P. Spall, Ahmet J. Cankut, Michael D. Ward, Julia A. Weinstein, Noorshida Mohd Ali

Publikováno v: Dalton transactions (Cambridge, England : 2003). 43(17)

A series of blue-luminescent Ir(III) complexes with a pendant binding site for lanthanide(III) ions has been synthesized and used to prepare Ir(III)/Ln(III) dyads (Ln = Eu, Tb, Gd). Photophysical studies were used to establish mechanisms of Ir→Ln (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccca3e4f8a4f93a76e63f2bb8d4f824f
https://pubmed.ncbi.nlm.nih.gov/24608523

Sensitisation of Eu(III)- and Tb(III)-based luminescence by Ir(III) units in Ir/lanthanide dyads: evidence for parallel energy-transfer and electron-transfer based mechanisms.

Autor: Sykes, Daniel, Cankut, Ahmet J., Mohd Ali, Noorshida, Stephenson, Andrew, Spall, Steven J. P., Parker, Simon C., Weinstein, Julia A., Ward, Michael D.

Publikováno v: Dalton Transactions: An International Journal of Inorganic Chemistry; 2014, Vol. 43 Issue 17, p6414-6428, 15p

Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells.

Autor: Jones S, Ahmet J, Ayton K, Ball M; Manchester Institute of Biotechnology, University of Manchester , Princess Street, Manchester, M1 7DN, U.K., Cockerill M, Fairweather E, Hamilton N, Harper P, Hitchin J, Jordan A, Levy C; Manchester Institute of Biotechnology, University of Manchester , Princess Street, Manchester, M1 7DN, U.K., Lopez R; Manchester Institute of Biotechnology, University of Manchester , Princess Street, Manchester, M1 7DN, U.K., McKenzie E; Manchester Institute of Biotechnology, University of Manchester , Princess Street, Manchester, M1 7DN, U.K., Packer M, Plant D, Simpson I, Simpson P, Sinclair I, Somervaille TC, Small H, Spencer GJ, Thomson G, Tonge M, Waddell I, Walsh J, Waszkowycz B, Wigglesworth M, Wiseman DH, Ogilvie D

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2016 Dec 22; Vol. 59 (24), pp. 11120-11137. Date of Electronic Publication: 2016 Dec 05.