Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ahmed Zafer"'
Publikováno v:
Bio-Protocol, Vol 14, Iss 12 (2024)
Chimeric antigen receptors (CARs) are synthetic fusion proteins that can reprogram immune cells to target specific antigens. CAR-expressing T cells have emerged as an effective treatment method for hematological cancers; despite this success, the mec
Externí odkaz:
https://doaj.org/article/3da41a5fd7f84bb69d160e028c5cde96
Autor:
Scott McComb, Mehdi Arbabi-Ghahroudi, Kevin A. Hay, Brian A. Keller, Sharlene Faulkes, Michael Rutherford, Tina Nguyen, Alex Shepherd, Cunle Wu, Anne Marcil, Annie Aubry, Greg Hussack, Devanand M. Pinto, Shannon Ryan, Shalini Raphael, Henk van Faassen, Ahmed Zafer, Qin Zhu, Susanne Maclean, Anindita Chattopadhyay, Komal Gurnani, Rénald Gilbert, Christine Gadoury, Umar Iqbal, Dorothy Fatehi, Anna Jezierski, Jez Huang, Robert A. Pon, Mhairi Sigrist, Robert A. Holt, Brad H. Nelson, Harold Atkins, Natasha Kekre, Eric Yung, John Webb, Julie S. Nielsen, Risini D. Weeratna
Publikováno v:
Molecular Therapy: Oncology, Vol 32, Iss 1, Pp 200775- (2024)
Chimeric antigen receptor (CAR) T cell therapies targeting B cell-restricted antigens CD19, CD20, or CD22 can produce potent clinical responses for some B cell malignancies, but relapse remains common. Camelid single-domain antibodies (sdAbs or nanob
Externí odkaz:
https://doaj.org/article/2b9541fc680c4b00a851c3c1cf34b814
Autor:
Jez Huang, Ying Betty Li, Claudie Charlebois, Tina Nguyen, Ziying Liu, Darin Bloemberg, Ahmed Zafer, Ewa Baumann, Caroline Sodja, Sonia Leclerc, Gwen Fewell, Qing Liu, Balabhaskar Prabhakarpandian, Scott McComb, Danica B. Stanimirovic, Anna Jezierski
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-15 (2022)
Abstract Human blood brain barrier (BBB) models derived from induced pluripotent stem cells (iPSCs) have become an important tool for the discovery and preclinical evaluation of central nervous system (CNS) targeting cell and gene-based therapies. Ch
Externí odkaz:
https://doaj.org/article/d53305594e694de79d738dc205e52f5f
Autor:
Scott McComb, Tina Nguyen, Alex Shepherd, Kevin A. Henry, Darin Bloemberg, Anne Marcil, Susanne Maclean, Ahmed Zafer, Rénald Gilbert, Christine Gadoury, Robert A. Pon, Traian Sulea, Qin Zhu, Risini D. Weeratna
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Epidermal growth factor family receptor (EGFR) is commonly overexpressed in many solid tumors and an attractive target for chimeric antigen receptor (CAR)-T therapy, but as EGFR is also expressed at lower levels in healthy tissues a therapeutic strat
Externí odkaz:
https://doaj.org/article/937b7637066e4c68807a453d8653a886
Autor:
Md Zahid Hossain, Mohammad Ali Alshahrani, Abdulmajeed Saeed Alasmari, Khaled Mashoor Hyderah, Ahmed Zafer Alshabab, Mutaz Ali Hassan, Abdo Mohammed Abdulrazzaq
Publikováno v:
Saudi Journal of Oral Sciences, Vol 8, Iss 3, Pp 150-156 (2021)
Introduction: Periodontal diseases (gingivitis and periodontitis) are one of the main concerns for oral health affecting around 20%–50% of the world population. Aims: The aim of this study was to formulate a predictive model for periodontal disease
Externí odkaz:
https://doaj.org/article/d956e397bec54895a525c670e7bea518
Autor:
Darin Bloemberg, Tina Nguyen, Susanne MacLean, Ahmed Zafer, Christine Gadoury, Komal Gurnani, Anindita Chattopadhyay, Josée Ash, Julie Lippens, Doreen Harcus, Martine Pagé, Annie Fortin, Robert A. Pon, Rénald Gilbert, Anne Marcil, Risini D. Weeratna, Scott McComb
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 16, Iss , Pp 238-254 (2020)
Chimeric antigen receptor (CAR) development involves extensive empirical characterization of antigen-binding domain (ABD)/CAR constructs for clinical suitability. Here, we present a cost-efficient and rapid method for evaluating CARs in human Jurkat
Externí odkaz:
https://doaj.org/article/b53d7d3e370f450b9900f99abd4d6663
Autor:
Fanny Tzelepis, Valeria Alcon, Renu Dudani, Komal Gurnani, Ahmed Zafer, Ellen S. Everson, Kevin G. Young, Holger Rüssmann, Lakshmi Krishnan, Subash Sad
Publikováno v:
Cell Reports, Vol 2, Iss 6, Pp 1710-1721 (2012)
Pathogens that reside in the phagosomes of infected cells persist despite the presence of potent T cell responses. We addressed the mechanism of immune evasion by using a mouse model of Salmonella typhimurium (ST). Recombinants of ST were generated t
Externí odkaz:
https://doaj.org/article/49f47a73423b4db59d9bacde7a690d6d
Autor:
Mohammad Abdo Abdulrazzaq, Faisal Hassan Almilaq, Abdulrahman Ahmed Aseri, Md. Zahid Hossain, Sultan Mohammed Alanazi, Monsour Heba Almakrami, Ahmed Zafer Alshabab, Ibrahim Saleh Alhareth, Khaled Mashoor Hyderah
Publikováno v:
European Journal of Dental and Oral Health. 2:1-10
Background: The common periodontal diseases are of public health concern, with 20-50 percent of the global population affected by gingivitis and or periodontitis. Aim: The aim of this study was to explore the common periodontal diseases occurring amo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ba4c0614696382d7f7db66013ffe402
https://doi.org/10.24018/ejdent.2021.2.3.54
https://doi.org/10.24018/ejdent.2021.2.3.54
Autor:
Anna Jezierski, Jez Huang, Betty (Ying) Li, Claudie Charlebois, Tina Nguyen, Ziying Liu, Darin Bloemberg, Ahmed Zafer, Ewa Baumann, Caroline Sodja, Sonia Leclerc, Gwen Fewell, Qing Liu, Balabhaskar Prabhakarpandian, Scott McComb, Danica B. Stanimirovic
Human blood brain barrier (BBB) models derived from induced pluripotent stem cell (iPSC) have become an important tool for discovery and preclinical evaluation of central nervous system (CNS) targeting cell and gene-based therapies. Chimeric antigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d930f7fe2945d57d9f3ebb16765cd200
https://doi.org/10.21203/rs.3.rs-1466429/v1
https://doi.org/10.21203/rs.3.rs-1466429/v1
Publikováno v:
J Leukoc Biol
Selectin-ligand interactions are important for leukocyte homing and functionality. The roles of selectin-ligand interactions in modulating immunity to intracellular infections are not completely understood. Mice lacking the expression of fucosyltrans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff8bafa82a8721aff8887ad9cb6e482f
https://doi.org/10.1002/jlb.4a1216-499r
https://doi.org/10.1002/jlb.4a1216-499r