New series of 4,6-diaryl pyrimidines: facile synthesis and antiproliferative activity as dual EGFR/VEGFR-2 inhibitors

Autor: Yaser A. Mostafa, Jalil Abdeljalil Assoud, Ahmed Y. Desoky, Samy Mohamady, Nesma M. Mohamed, Ola I. A. Salem, Zainab M. Almarhoon, Stefan Bräse, Bahaa G. M. Youssif

Publikováno v: Frontiers in Chemistry, Vol 12 (2024)

IntroductionWe developed and produced a new series of 4,6-diaryl-pyrimidines 9–29 as antiproliferative agents targeting EGFR/VEGFR-2.MethodsThe antiproliferative efficacy of the novel targets was assessed against a panel of 60 NCI cancer cell lines

Externí odkaz: https://doaj.org/article/6cd27a190de540de84af81cc18e46b04

Self-adaptive Bioinspired Hummingbird-wing Stimulated Triboelectric Nanogenerators

Autor: Jean W. Zu, Islam Hassan, Abdelsalam A. Ahmed, Ken-Tye Yong, Nishtha Panwar, Ali Radhi, Ahmed Y. Desoky, Peiyi Song, Swee Chuan Tjin, Mohamed Gamaleldin, David Sinton

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Scientific Reports

Bio-inspired technologies have remarkable potential for energy harvesting from clean and sustainable energy sources. Inspired by the hummingbird-wing structure, we propose a shape-adaptive, lightweight triboelectric nanogenerator (TENG) designed to e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25df0e538f3ea477001340203e1a6f11
https://doaj.org/article/19b170fd513d431f98071103b038d398

Structural and Kinetic Studies of the Potent Inhibition of Metallo-β-lactamases by 6-Phosphonomethylpyridine-2-carboxylates

Autor: Laura Marrone, Emily E. Whittle, Ahmed Y. Desoky, Anthony P. Krismanich, Fanxing Zeng, James Spencer, Gary I. Dmitrienko, Philip Hinchliffe, Matthew B. Avison, Stefan Siemann, Niels C. Bols, Geneviève Labbé, Carol A. Tanner, Valerie J. Goodfellow, Karina Calvopiña

Publikováno v: Hinchliffe, P, Tanner, C A, Krismanich, A P, Labbé, G, Goodfellow, V J, Marrone, L, Desoky, A Y, Calvopiña, K, Whittle, E E, Zeng, F, Avison, M B, Bols, N C, Siemann, S, Spencer, J & Dmitrienko, G I 2018, ' Structural and Kinetic Studies of the Potent Inhibition of Metallo-β-lactamases by 6-Phosphonomethylpyridine-2-carboxylates ', Biochemistry, vol. 57, no. 12, pp. 1880-1892 . https://doi.org/10.1021/acs.biochem.7b01299

There are currently no clinically available inhibitors of metallo-β-lactamases (MBLs), enzymes that hydrolyze β-lactam antibiotics and confer resistance to Gram-negative bacteria. Here we present 6-phosphonomethylpyridine-2-carboxylates (PMPCs) as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a1821f399444ce71d2e778de7594f21
https://pubmed.ncbi.nlm.nih.gov/29485857

A Simple Molecular Rotor for Defining Nucleoside Environment within a DNA Aptamer-Protein Complex

Autor: Abigail J Van Riesen, Ahmed Y. Desoky, Florence D. Berger, Thomas Z. Cservenyi, Richard A. Manderville

Publikováno v: ACS chemical biology. 11(9)

The simple 5-furyl-2'-deoxyuridine ((Fur)dU) nucleobase exhibits dual probing characteristics displaying emissive sensitivity to changes in microenvironment polarity and to changes in solvent rigidity due to its molecular rotor character. Here, we de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5179615af0fe30bfac044c4de2d69f39
https://pubmed.ncbi.nlm.nih.gov/27447371

Preparation of trifluoroethyl- and phenyl-protected sulfates using sulfuryl imidazolium salts

Autor: Ahmed Y. Desoky, Laura J. Ingram, Scott D. Taylor, Jenifer L. Hendel

Publikováno v: Tetrahedron. 67:1281-1287

Sulfuryl imidazolium salts (SIS’s), a new class of sulfating agents, were prepared bearing the trifluoroethyl (TFE) and phenyl groups, two functionalities that have been used for the protection of sulfate monoesters, by subjecting the corresponding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02d7042f32f5219380966192ae55a834
https://doi.org/10.1016/j.tet.2010.11.085