Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Ahmed T Ayoub"'
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 6, p e1004313 (2015)
Microtubules are long filamentous hollow cylinders whose surfaces form lattice structures of αβ-tubulin heterodimers. They perform multiple physiological roles in eukaryotic cells and are targets for therapeutic interventions. In our study, we carr
Externí odkaz:
https://doaj.org/article/d7478414d1ba4da28ff54cb728ba4cc8
Autor:
Marc St George, Ahmed T Ayoub, Asok Banerjee, Cassandra D M Churchill, Philip Winter, Mariusz Klobukowski, Carol E Cass, Richard F Ludueña, Jack A Tuszynski, Sambasivarao Damaraju
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129168 (2015)
Our previous work identified an intermediate binding site for taxanes in the microtubule nanopore. The goal of this study was to test derivatives of paclitaxel designed to bind to this intermediate site differentially depending on the isotype of β-t
Externí odkaz:
https://doaj.org/article/f52f0efb56234a809812dbd19309eb40
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 1488-1496 (2021)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
Modulation of the structure and function of biomaterials is essential for advancing bio-nanotechnology and biomedicine. Microtubules (MTs) are self-assembled protein polymers that are essential for fundamental cellular process
Modulation of the structure and function of biomaterials is essential for advancing bio-nanotechnology and biomedicine. Microtubules (MTs) are self-assembled protein polymers that are essential for fundamental cellular process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a7f984af2f5762d14156680bf0d4f2
https://doi.org/10.1016/j.csbj.2021.02.007
https://doi.org/10.1016/j.csbj.2021.02.007
Autor:
Mostafa A. Fouad, Eman Maher Zahran, Samar Yehia Desoukey, Mohamed Kamel, Hany Ezzat Khalil, M. Alaraby Salem, Ahmed T. Ayoub, Usama Ramadan Abdelmohsen
Publikováno v:
South African Journal of Botany. 131:311-319
Ocimum forskolei (Habak), Lamiaceae, is an endemic species from Yemen and KSA; where our present study was aimed at investigating the Metabolic profiling coupled with LC HR-MS analysis of the dichloromethane fraction from the aerial parts of that pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aa50cfba1e11025005b6716c33e0559
https://doi.org/10.1016/j.sajb.2020.03.004
https://doi.org/10.1016/j.sajb.2020.03.004
Publikováno v:
Data in Brief, Vol 38, Iss, Pp 107337-(2021)
Data in Brief
Data in Brief
We present molecular dynamics (MD) trajectories of a single ring of B-lattice microtubule ring consisting of 13 tubulin heterodimers. The data contain trajectories of this molecular system ran under various conditions (two temperature values, three i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc895e00475d62a40a21e5c9b1593ab
http://www.sciencedirect.com/science/article/pii/S2352340921006211
http://www.sciencedirect.com/science/article/pii/S2352340921006211
Autor:
Marina Lusic, Steeve Boulant, Iart Luca Shytaj, Christopher J. Neufeldt, Petr Chlanda, Mirko Cortese, Ralf Bartenschlager, Oliver T. Fackler, Ahmed T. Ayoub, Bojana Lucic, Mahmoud M. Tolba, Lara Gallucci, Andrea Savarino, Liv Zimmermann, Vibor Laketa, Mohamed Fares, Megan L. Stanifer
Combinations of direct-acting antivirals are needed to minimize drug-resistance mutations and stably suppress replication of RNA viruses. Currently, there are limited therapeutic options against the Severe Acute Respiratory Syndrome Corona Virus 2 (S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89a318db23beae4fa9314b71a9390ce0
https://doi.org/10.1101/2021.03.09.434219
https://doi.org/10.1101/2021.03.09.434219
Autor:
Jack A. Tuszynski, Marianne Nebsen, Medhat A. Al-Ghobashy, Olivia A. Attallah, Ahmed T. Ayoub
Publikováno v:
RSC Advances. 8:14280-14292
Analytical methods should be accurate and specific to measure plasma drug concentration. Nevertheless, current sample preparation techniques suffer from limitations, including matrix interference and intensive sample preparation. In this study, a nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6812907d0785503f8960810b8acbc051
https://doi.org/10.1039/c8ra02379d
https://doi.org/10.1039/c8ra02379d
Autor:
Daniel Havelka, Ahmed T. Ayoub, Francesca Apollonio, Jiri Prusa, Jack A. Tuszynski, Michal Cifra, Micaela Liberti, Paolo Marracino
Intense pulsed electric fields are known to act at the cell membrane level and are already being exploited in biomedical and biotechnological applications. However, it is not clear if intra-cellular components such as cytoskeletal proteins could be d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9722c01326fc59db7be3784509a6ac
https://doi.org/10.1101/533984
https://doi.org/10.1101/533984
Autor:
Daniel Havelka, Michal Cifra, Francesca Apollonio, Jack A. Tuszynski, Jiří Průša, Micaela Liberti, Ahmed T. Ayoub, Paolo Marracino
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Intense pulsed electric fields are known to act at the cell membrane level and are already being exploited in biomedical and biotechnological applications. However, it is not clear if electric pulses within biomedically-attainable parameters could di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1daec1839d4cb2def6ef50cfc4ac94
http://hdl.handle.net/11573/1412004
http://hdl.handle.net/11573/1412004
Publikováno v:
ACS Omega
ACS Omega, Vol 4, Iss 2, Pp 4461-4471 (2019)
ACS Omega, Vol 4, Iss 2, Pp 4461-4471 (2019)
Lankacidin C, which is an antibiotic produced by the organism Streptomyces rochei, shows considerable antitumor activity. The mechanism of its antitumor activity remained elusive for decades until it was recently shown to overstabilize microtubules b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fabe49baf73173949167649d4179c3a3
https://pubmed.ncbi.nlm.nih.gov/31459641
https://pubmed.ncbi.nlm.nih.gov/31459641