Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Ahmed S I, Aly"'
Autor:
Leila Kianifard, Ab. Matteen Rafiqi, Osman Akcakir, Ahmed S. I. Aly, Peter F. Billingsley, Serdar Uysal
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The control of malaria parasite transmission from mosquitoes to humans is hampered by decreasing efficacies of insecticides, development of drug resistance against the last-resort antimalarials, and the absence of effective vaccines. Herein,
Externí odkaz:
https://doaj.org/article/1534aaddcdb448de98cf1a1e30b61c83
Publikováno v:
Vaccines, Vol 10, Iss 11, p 1884 (2022)
Host cell-free, axenic development of liver stages (LS) of the malaria parasite has been demonstrated. Here we explored axenic liver stages as a novel live whole parasite malaria vaccine platform, which is unaltered and not prone to human-error, comp
Externí odkaz:
https://doaj.org/article/9bb49840d2d84a70a22b145d39af9908
Autor:
Paul J. F. Rider, Mohd Kamil, Ilknur Yilmaz, Habibe N. Atmaca, Merve Kalkan-Yazici, Mehmet Ziya Doymaz, Konstantin G. Kousoulas, Ahmed S. I. Aly
Publikováno v:
Vaccines, Vol 10, Iss 2, p 300 (2022)
Here, we present the construction of an attenuated herpes simplex virus type-1 (HSV-1)-vectored vaccine, expressing three liver-stage (LS) malaria parasite exported proteins (EXP1, UIS3 and TMP21) as fusion proteins with the VP26 viral capsid protein
Externí odkaz:
https://doaj.org/article/9087e92fed274eeca9d6468fef19a1c0
Publikováno v:
Biology Open, Vol 5, Iss 8, Pp 1022-1029 (2016)
Polyamines are positively-charged organic molecules that are important for cellular growth and division. Polyamines and their synthesizing enzymes are particularly abundant in rapidly proliferating eukaryotic cells such as parasitic protozoa and canc
Externí odkaz:
https://doaj.org/article/d2365126f23e42bbb2a77dd2cfbd1f15
Publikováno v:
FEMS Microbiology Letters. 370
Iron is an essential cofactor for eukaryotic cells, as well as a toxic metal under certain conditions. On the other hand, glucose is the preferred energy and carbon source by most organisms and is an important signaling molecule in the regulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76a0779e01c6c3e1e1729879ffcd4b15
https://doi.org/10.1093/femsle/fnad022
https://doi.org/10.1093/femsle/fnad022
Autor:
Mohd Kamil, Habibe N. Atmaca, Sinem Unal, Umit Y. Kina, Pinar Burak, Gozde Deveci, Ilknur Yilmaz, Ahmed S. I. Aly
Publikováno v:
Antimicrob Agents Chemother
We generated highly chloroquine (CQ)-resistant (ResCQ) Plasmodium yoelii parasites by stepwise exposure to increasing concentrations of CQ and CQ-sensitive parasites (SenCQ) by parallel mock treatments. No mutations in genes that are associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed4ae8a63a9e381ec803faa3211ebe0
https://doi.org/10.1128/aac.00269-22
https://doi.org/10.1128/aac.00269-22
Autor:
Sophia M. Reeder, Emma L. Reuschel, Mamadou A. Bah, Kun Yun, Nicholas J. Tursi, Kevin Y. Kim, Jacqueline Chu, Faraz I. Zaidi, Ilknur Yilmaz, Robert J. Hart, Benjamin Perrin, Ziyang Xu, Laurent Humeau, David B. Weiner, Ahmed S. I. Aly
Publikováno v:
Vaccines, Vol 8, Iss 1, p 21 (2020)
The need for a malaria vaccine is indisputable. A single vaccine for Plasmodium pre-erythrocytic stages targeting the major sporozoite antigen circumsporozoite protein (CSP) has had partial success. Additionally, CD8+ T cells targeting liver-stage (L
Externí odkaz:
https://doaj.org/article/bf7ea69c369f4f4399d88722a7c17bb4
Publikováno v:
mBio, Vol 8, Iss 4 (2017)
ABSTRACT In sexually reproducing organisms, meiosis is an essential step responsible for generation of haploid gametes from diploid somatic cells. The quest for understanding regulatory mechanisms of meiotic recombination in Plasmodium led to identif
Externí odkaz:
https://doaj.org/article/aac28b585e6e485389f6b0e47717bc0d
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)
Coenzyme A (CoA) is an essential universal cofactor for all prokaryotic and eukaryotic cells. In nearly all non-photosynthetic cells, CoA biosynthesis depends on the uptake and phosphorylation of vitamin B5 (pantothenic acid or pantothenate). Recentl
Externí odkaz:
https://doaj.org/article/a79a8b0a45a247d8bcc08f018ba1d2b3
Publikováno v:
Biomed Opt Express
Diagnosis of malaria in endemic areas is hampered by the lack of a rapid, stain-free and sensitive method to directly identify parasites in peripheral blood. Herein, we report the use of Fourier ptychography to generate wide-field high-resolution qua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af1346c91991769ecc427ed4fdac3df3
https://europepmc.org/articles/PMC9352279/
https://europepmc.org/articles/PMC9352279/
