Deoxamuscaroneoxime derivatives as useful muscarinic agonists to explore the muscarinic subsite

Autor: Michela Buccioni, Francesca Novi, Roberto Maggio, Alessandro Piergentili, Franco Cantalamessa, Maria Pigini, Cinzia Nasuti, Wilma Quaglia, Piero Angeli, Santi Spampinato, Gabriella Marucci, Mario Giannella, Ahmed R. Qasem

Publikováno v: Life Sciences. 70:1427-1446

A series of muscarinic agonists, straight chained, branched, cyclic alkyl and aromatic derivatives of the oxime 1 (demox) was designed with the aim of investigating their activity on muscarinic receptor subtypes. Effects on M 1 receptor were assessed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ad87c1259cf821bd1c2e347d40a8bbf
https://doi.org/10.1016/s0024-3205(01)01521-1

Contribution of alpha4beta1 integrin to the antiallergic effect of levocabastine

Autor: Paolo Govoni, Santi Spampinato, Ahmed R. Qasem, Monica Baiula, Claudio Bucolo, Domenico Fascì, Andrea Bedini, Antonino Spartà

Publikováno v: Biochemical pharmacology. 76(6)

Levocabastine is an antiallergic drug acting as a histamine H1-receptor antagonist. In allergic conjunctivitis (AC), it may also antagonize up-regulation of the intercellular adhesion molecule-1 (ICAM-1) expressed on epithelial conjunctival cells. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220a7172da755b6e69df1682da09b18e
https://pubmed.ncbi.nlm.nih.gov/18680729

Stability against enzymatic hydrolysis of endomorphin-1 analogues containing beta-proline

Autor: Santi Spampinato, Ahmed R. Qasem, Giuliana Cardillo, Alessandra Tolomelli, Luca Gentilucci, Maria Calienni

Publikováno v: 1 (2003): 1498–1502.
info:cnr-pdr/source/autori:G. Cardillo, L. Gentilucci, A. Tolomelli, M. Calienni, A. R. Qasem, S. Spampinato/titolo:Stability against enzymatic hydrolysis of endomorphin-1 analogues containing b-proline/doi:/rivista:/anno:2003/pagina_da:1498/pagina_a:1502/intervallo_pagine:1498–1502/volume:1

The enantiomer of endomorphin-1 (Tyr-Pro-Trp-PheNH2) and the analogues containing (S)- or (R)-beta-proline have been synthesized, and their affinities towards mu-opioid receptors have been measured. As expected, the incubations of the different pepti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b93e2807a159fd69b8c36b4cb9b1a6
https://pubmed.ncbi.nlm.nih.gov/12926278

Conformational analysis and m-opioid receptor affinity of short peptides, endomorphin models in a low polarity solvent

Autor: Santi Spampinato, Luca Gentilucci, Maria Calienni, Alessandra Tolomelli, Ahmed R. Qasem, Giuliana Cardillo

Publikováno v: 1 (2003): 3010–3014.
info:cnr-pdr/source/autori:G. Cardillo, L. Gentilucci, A. Tolomelli, A., S. Spampinato, M.Calienni/titolo:Conformational analysis and m-opioid receptor affinity of short peptides, endomorphin models in a low polarity solvent/doi:/rivista:/anno:2003/pagina_da:3010/pagina_a:3014/intervallo_pagine:3010–3014/volume:1

Peptide carbamates containing the sequence H-Pro-Trp-PheNH2 showed in CDCl3 restricted conformations stabilized by the presence of a gamma-turn. To test the reliability of the peptides as endomorphin conformational models, we measured the affinities

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d433d92c7871538741ba14cde3063f7
https://publications.cnr.it/doc/70105