Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Ahmed Mamai"'
Autor:
Alice Shi Ming Li, Serah Kimani, Brian Wilson, Mahmoud Noureldin, Héctor González-Álvarez, Ahmed Mamai, Laurent Hoffer, John P. Guilinger, Ying Zhang, Moritz von Rechenberg, Jeremy S. Disch, Christopher J. Mulhern, Belinda L. Slakman, John W. Cuozzo, Aiping Dong, Gennady Poda, Mohammed Mohammed, Punit Saraon, Manish Mittal, Pratik Modh, Vaibhavi Rathod, Bhashant Patel, Suzanne Ackloo, Vijayaratnam Santhakumar, Magdalena M Szewczyk, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, Richard Marcellus, Marie-Aude Guié, Anthony D. Keefe, Peter J. Brown, Levon Halabelian, Rima Al-awar, Masoud Vedadi
Publikováno v:
Journal of Medicinal Chemistry. 66:5041-5060
Autor:
Ahmed Mamai, Anh M. Chau, Brian J. Wilson, Iain D. Watson, Babu B. Joseph, Pandiaraju R. Subramanian, Monzur M. Morshed, Justin A. Morin, Michael A. Prakesch, Tianbao Lu, Pete Connolly, Douglas A. Kuntz, Neil C. Pomroy, Gennady Poda, Kong Nguyen, Richard Marcellus, Graig Strathdee, Brigitte Theriault, Ratheesh Subramaniam, Mohammed Mohammed, Ayome Abibi, Manuel Chan, Jeffrey Winston, Taira Kiyota, Elijus Undzys, Ahmed Aman, Nigel Austin, Marc Du Jardin, Kathryn Packman, Ulrike Phillippar, Riccardo Attar, James Edwards, Jeff O’Meara, David E. Uehling, Rima Al-awar, Gilbert G. Privé, Methvin B. Isaac
Publikováno v:
ACS Medicinal Chemistry Letters. 14:199-210
Autor:
Sumera Perveen, Carlos A. Zepeda-Velázquez, David McLeod, Richard Marcellus, Mohammed Mohammed, Megha Abbey, Deeba Ensan, Dimitrios Panagopoulos, Viacheslav Trush, Elisa Gibson, Aiping Dong, Levon Halabelian, Gennady Poda, Julie Owen, Ahmed Aman, Taira Kiyota, Ahmed Mamai, Cheryl H. Arrowsmith, Peter J. Brown, Matthieu Schapira, Rima Al-awar, Masoud Vedadi
RBBP4 is a nuclear WD40 motif-containing protein widely implicated in various cancers and a putative drug target. It interacts with multiple proteins within diverse complexes such as nucleosome remodeling and deacetylase (NuRD) complex and polycomb r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44cf4448a4ef25f58c7154a98ab95c5c
https://doi.org/10.1101/2022.01.05.475077
https://doi.org/10.1101/2022.01.05.475077
Autor:
Kurumi Y. Horiuchi, Roslin Adamson, Ahmed Aman, Ahmed Mamai, Soyoung Kim, Haiching Ma, Sue Cramp, Taira Kiyota, Alex N. Bullock, David Uehling, Jeff A O'Meara, Eleanor Williams, Methvin Isaac, J Nicole Hamblin, Ekaterina Kuznetsova, Julie Owen, David McLeod, Jong Fu Wong, Gennady Poda, David Smil, Owen G Roberts, Aled M. Edwards, Alison Howarth, Brian J. Wilson, Rima Al-awar
There are currently no effective chemotherapeutic drugs approved for the treatment of diffuse intrinsic pontine glioma (DIPG), an aggressive pediatric cancer resident in the pons region of the brainstem. Radiation therapy is beneficial but not curati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dafcc5d75dab7a89554a419605d3d343
https://ora.ox.ac.uk/objects/uuid:4cce623b-5222-4aab-8937-7fb64280705f
https://ora.ox.ac.uk/objects/uuid:4cce623b-5222-4aab-8937-7fb64280705f
Autor:
Dongfang Meng, Dann L. Parker, Robin Kirwan, M A Powles, Jennifer Nielsen Kahn, James M. Apgar, Fred Racine, Paul A. Liberator, Amy M. Flattery, Andrew Galgoci, Kingsley H. Nelson, James M. Balkovec, Andrew S. Misura, Weiming Fan, Donald M. Sperbeck, Michael Robert Peel, Robert A. Giacobbe, Mark L. Greenlee, Ahmed Mamai, Jasminka Dragovic, Kenneth J. Wildonger, Hao Liu, Robert R. Wilkening, Mary Motyl, Shu Lee, Ming-Jo Hsu, Charles Gill, George K. Abruzzo
Publikováno v:
Bioorganicmedicinal chemistry letters. 32
We previously reported medicinal chemistry efforts that identified MK-5204, an orally efficacious β-1,3-glucan synthesis inhibitor derived from the natural product enfumafungin. Further extensive optimization of the C2 triazole substituent identifie
Autor:
Gennady Poda, Marko Jakopović, Levon Halabelian, Methvin Isaac, Nikolina Radulovich, Michael Prakesch, Caroline Huard, Ahmed Aman, Dhananjay Joshi, Zhong Yao, Manuel Chan, Wiebke Schormann, Richard Marcellus, Babu Joseph, Rima Al-awar, Luka Drecun, Mohammed Mohammed, Li Niu, Brigitte L. Thériault, María Sánchez-Osuna, David Uehling, Ahmed Mamai, Ming-Sound Tsao, Jasmin Coulombe-Huntington, Taira Kiyota, Evelyne Lima-Fernandes, Punit Saraon, Ankit Rai, Jamie Snider, David W. Andrews, Cheryl H. Arrowsmith, Farzaneh Aboualizadeh, Natasha B. Leighl, Miroslav Samaržija, Victoria Wong, Anna Lyakisheva, Mike Tyers, Ratheesh Subramanian, Adrian G. Sacher, Fengling Li, Masoud Vedadi, Igor Stagljar, Shivanthy Pathmanathan
Publikováno v:
Journal of Molecular Biology. 433:167294
Activating mutations in the epidermal growth factor receptor (EGFR) are common driver mutations in non-small cell lung cancer (NSCLC). First, second and third generation EGFR tyrosine kinase inhibitors (TKIs) are effective at inhibiting mutant EGFR N
Autor:
James M. Balkovec, Robert A. Giacobbe, Jennifer Nielsen Kahn, Ming Jo Hsu, Weiming Fan, Ahmed Mamai, Michael Robert Peel, James M. Apgar, Amy M. Flattery, Paul A. Liberator, Fred Racine, Bahanu Habulihaz, Mary Motyl, Kingsley H. Nelson, Robert R. Wilkening, Robin Kirwan, M A Powles, George K. Abruzzo, Andrew Galgoci, Charles Gill, Andrew S. Misura, Shu Lee, Jasminka Dragovic, Hao Liu, Mark L. Greenlee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5813-5818
The clinical success of the echinocandins, which can only be administered parentally, has validated β-1,3-glucan synthase (GS) as an antifungal target. Semi-synthetic modification of enfumafungin, a triterpene glycoside natural product, was performe
Autor:
Brian J. Wilson, Methvin Isaac, Ayome Abibi, Michael Prakesch, Ratheesh Subramaniam, Ahmed Aman, Doug Kuntz, Rima Al-awar, Elijus Undzys, Justin Morin, Jeffrey Winston, Neil C. Pomroy, Craig Strathdee, Carly Griffin, Pandiaraju Subramanian, Herman Cheung, Gil G. Privé, Iain D. G. Watson, Taira Kiyota, Manuel Chan, Richard Marcellus, Anh Chau, Gennady Poda, Babu Joseph, David Uehling, Brigitte L. Thériault, Ahmed Mamai
Publikováno v:
Cancer Research. 79:7-7
The transcription factor B cell lymphoma 6 (BCL6) is required for the generation of an effective humoral immune response through the development and maintenance of germinal centers (GCs). The inhibition of the protein−protein interaction between BC
Autor:
Dann L. Parker, James M. Apgar, Robert A. Giacobbe, Ming Jo Hsu, Kingsley H. Nelson, Gregory J. Pacofsky, Paul A. Liberator, Fred Racine, Dongfang Meng, Ghjuvanni Coti, James M. Balkovec, Ahmed Mamai, Brian H. Heasley, Mark L. Greenlee, Jennifer Nielsen Kahn, Michael Robert Peel, Robert R. Wilkening, Hao Liu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6811-6816
Orally bioavailable inhibitors of β-(1,3)- d -glucan synthase have been pursued as new, broad-spectrum fungicidal therapies suitable for treatment in immunocompromised patients. Toward this end, a collaborative medicinal chemistry program was establ
Autor:
Ahmed Mamai, Susanna Grönberg, Rima Al-awar, Tommy Alain, Stephen Baird, David Uehling, Douglas J. Mahoney, Jan Brun, David F. Stojdl, Methvin Isaac, Ahmed Aman, Charles Lefebvre, Mikael Prakesh, Theresa Falls, Cina A. Sanaei, Brian J. Wilson, Nelson Pearce, Kristina J. Allan
Publikováno v:
Cancer Cell. 20:443-456
SummaryTo identify therapeutic opportunities for oncolytic viral therapy, we conducted genome-wide RNAi screens to search for host factors that modulate rhabdoviral oncolysis. Our screens uncovered the endoplasmic reticulum (ER) stress response pathw