Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Ahmed M. Shoieb"'
Autor:
Arun R. Pandiri, Molly H. Boyle, Adam D. Aulbach, William Siska, Natalie D. Keirstead, Mary Carsillo, Ahmed M. Shoieb, Krista M. D. La Perle, Carole E. Harbison, Bindu Bennet, Torrie A. Crabbs
Publikováno v:
Toxicologic Pathology. 50:252-265
Samples of biologic specimens and their derivatives (eg, wet tissues, paraffin-embedded tissue blocks, histology slides, frozen tissues, whole blood, serum/plasma, and urine) are routinely collected during the course of nonclinical toxicity studies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a660b59b33db03c5d760cbb0b285235
https://doi.org/10.1177/01926233211049156
https://doi.org/10.1177/01926233211049156
Autor:
Jean G. Sathish, Siddhartha Bhatt, Jamie K. DaSilva, Declan Flynn, Stephen Jenkinson, Amit S. Kalgutkar, Maggie Liu, Balasubramanian Manickam, Jason Pinkstaff, William J. Reagan, Norimitsu Shirai, Ahmed M. Shoieb, Madhu Sirivelu, Saurabh Vispute, Allison Vitsky, Karen Walters, Todd A. Wisialowski, Lawrence W. Updyke
Publikováno v:
International journal of toxicology. 41(4)
COVID-19 is a potentially fatal infection caused by the SARS-CoV-2 virus. The SARS-CoV-2 3CL protease (Mpro) is a viral enzyme essential for replication and is the target for nirmatrelvir. Paxlovid (nirmatrelvir co-administered with the pharmacokinet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea1a7a89320457f06d9cf5a899cc71f
https://pubmed.ncbi.nlm.nih.gov/35603517
https://pubmed.ncbi.nlm.nih.gov/35603517
Autor:
Rani S. Sellers, Ahmed M. Shoieb, Shelli J. Schomaker, William J. Reagan, David W. Clarke, Victoria Markiewicz
Publikováno v:
Toxicologic Pathology. 48:845-856
The objectives were to characterize the kinetics of acute phase proteins (APPs) α-2 macroglobulin (A2M), α-1 acid glycoprotein (A1AGP), and fibrinogen (FIB), and injection site macroscopic and microscopic findings following intramuscular administra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c94467c3a93989a7a1badc445ab0ca
https://doi.org/10.1177/0192623320957281
https://doi.org/10.1177/0192623320957281
Autor:
Young-Ho Song, Crystal T. Bluette, Wenhu Huang, Chang-Ning Liu, Ahmed M. Shoieb, Balasubramanian Manickam, Qinghai Peng, Wei Zhang, Eyoung Shin
Publikováno v:
International journal of toxicology. 40(1)
Clinical use of the chemotherapeutic agent vincristine (VCR) is limited by chemotherapy-induced peripheral neuropathy (CiPN). A new formulation of VCR encapsulated by nanoparticles has been proposed and developed to alleviate CiPN. We hypothesized in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf59abea6111e2ad568950dd5fe8faab
https://pubmed.ncbi.nlm.nih.gov/33148080
https://pubmed.ncbi.nlm.nih.gov/33148080
Autor:
Ahmed M. Shoieb, Hesham S. Borg
Publikováno v:
Open Access Macedonian Journal of Medical Sciences; Vol. 8 No. D (2020): D-Dental Sciences; 173-177
AIM: The aim of the study was to compare the retention of two modalities: Multi-suction cup denture, and denture adhesive and to evaluate the change of retention by different time intervals. PATIENTS AND METHODS: Twelve completely edentulous patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05cf113f72f9ee4561ad90fcf94f83a
https://www.id-press.eu/mjms/article/view/4746
https://www.id-press.eu/mjms/article/view/4746
Autor:
Mohamed Abas, Mohamed A. Helal, Mostafa I Fayad, Rady El-Baz, Ahmed M. Shoieb, Mohammed M. Gad
Publikováno v:
Brazilian Dental Science. 23
Objective: was to evaluate the retentive force, fatigue resistance and deformity of clasps made from two materials cobalt chromium and poly ether et her ketone (PEEK). Material and Methods: sixteen models were fabricated, each one having lower 1st mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf9a3c86e5f791435cb77141c9d5baaa
https://doi.org/10.14295/bds.2020.v23i3.1935
https://doi.org/10.14295/bds.2020.v23i3.1935
Autor:
Chedo M. Bagi, David E. Zakur, Chris J. Somps, Chang-Ning Liu, Ahmed M. Shoieb, Edwin Berryman, Ingrid D. Pardo, Jon C. Cook, Magalie Boucher
Publikováno v:
Journal of Applied Toxicology. 38:193-200
Chemotherapy-induced peripheral neuropathy (CiPN) is a frequent adverse effect in patients and a leading safety consideration in oncology drug development. Although behavioral assessment and microscopic examination of the nerves and dorsal root gangl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae9129a49515d8e77c803ddd2e8cb907
https://doi.org/10.1002/jat.3513
https://doi.org/10.1002/jat.3513
Autor:
Dilinie P. Fernando, Gary Erik Aspnes, Sophie Y. Lavergne, Daniel W. Kung, Michael Herr, I. D. Pardo, Qifang Li, Norimitsu Shirai, Bryan Goodwin, Suvi T. M. Orr, Jun Zhou, Julie Purkal, Matthew S. Dowling, Kentaro Futatsugi, R. J. Barnes, Declan Flynn, Ahmed M. Shoieb, David Hepworth, T. J. Schmahai, Mark Niosi, W. P. Gorczyca, Kim Huard, John C. Pettersen, Sylvie Perez, Shawn Cabral, James R. Gosset, Theunis C. Goosen
Publikováno v:
MedChemComm. 8:771-779
Small molecule DGAT2 inhibitors have shown promise for the treatment of metabolic diseases in preclinical models. Herein, we report the first toxicological evaluation of imidazopyridine-based DGAT2 inhibitors and show that the arteriopathy associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343a6e4a5a0b00a3db0ba47eb2198e13
https://doi.org/10.1039/c6md00564k
https://doi.org/10.1039/c6md00564k
Autor:
Leslie G. Lorello, Jim McNally, Hugh D. Conlon, Michael W. Leach, Carol F. Kirchhoff, Teresa Annette Smolarek, Andrew Saati, Sarah Koob, Mazin Derzi, Ahmed M. Shoieb, Penny Sharpe, Michael W. Bolt, Theodore R. Johnson
Publikováno v:
Advances in Therapy
Introduction PF-06438179, a potential biosimilar to Remicade® (infliximab, Janssen Biotech, Inc.), is a chimeric mouse–human monoclonal antibody targeting human tumor necrosis factor alpha (TNF). Methods Analytical (small subset reported here) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af1eb4ef54c3121972985f519b27fd07
https://doi.org/10.1007/s12325-016-0403-9
https://doi.org/10.1007/s12325-016-0403-9
Autor:
Michael W. Leach, Leslie G. Lorello, Gregory L. Finch, Sharon L. Ripp, Ahmed M. Shoieb, Shawn P. O'Neil, Jameel Syed, Zaher A. Radi, Matthew S. Thompson, Mazin Derzi
Publikováno v:
Regulatory Toxicology and Pharmacology. 112:104587
Adalimumab, a recombinant fully human monoclonal antibody targeting tumor necrosis factor (TNF), is approved in the United States and Europe to treat various inflammatory and autoimmune indications. Biosimilars are approved biologics highly similar,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b782c4c13b3cd4d270d27d6799df466
https://doi.org/10.1016/j.yrtph.2020.104587
https://doi.org/10.1016/j.yrtph.2020.104587