Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Ahmed M Alafeefy"'
Autor:
Fatmah Ali S. Alasmary, Dalal A. Abdullah, Vijay H. Masand, Abir Ben Bacha, Abdelsattar Mansour Omar Ebeid, Moustafa E. El-Araby, Ahmed M Alafeefy
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
Quinoxalines are benzopyrazine derivatives with significant therapeutic impact in the pharmaceutical industry. They proved to be useful against inflammation, bacterial, fungal, viral infection, diabetes and other applications. Very recently, in Janua
Externí odkaz:
https://doaj.org/article/ffec69356bab4219b307daf6812c7f51
Autor:
Abdelkader E Ashour, Shazia Jamal, Vino T Cheryan, Magesh Muthu, Khairy M A Zoheir, Ahmed M Alafeefy, Adel R Abd-Allah, Edi Levi, Adi L Tarca, Lisa A Polin, Arun K Rishi
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66733 (2013)
Medulloblastomas (MBs) constitute an aggressive class of intracranial pediatric tumors. Current multimodality treatments for MBs include surgery, ionizing radiation, and chemotherapy. Toxic side effects of therapies coupled with high incidence of rec
Externí odkaz:
https://doaj.org/article/e497f474c46f4f8b89d52f4f5def5f99
Autor:
Fatmah A. S. Alasmary, Anna M. Snelling, Mohammed E. Zain, Ahmed M. Alafeefy, Amani S. Awaad, Nazira Karodia
Publikováno v:
Molecules, Vol 20, Iss 8, Pp 15206-15223 (2015)
A library of 53 benzimidazole derivatives, with substituents at positions 1, 2 and 5, were synthesized and screened against a series of reference strains of bacteria and fungi of medical relevance. The SAR analyses of the most promising results showe
Externí odkaz:
https://doaj.org/article/d167e173dece4e8598fb30c7f0cf800c
Autor:
Anastasija Balašova, Mikhail Krasavin, Aleksandrs Pustenko, Raivis Žalubovskis, Claudiu T. Supuran, Ahmed M. Alafeefy, Alessio Nocentini
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 245-254 (2020)
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 245-254 (2020)
A new series of homosulfocoumarins (3H-1,2-benzoxathiepine 2,2-dioxides) possessing various substitution patterns and moieties in the 7, 8 or 9 position of the heterocylic ring were prepared by original procedures and investigated for the inhibition
Publikováno v:
Acta Crystallographica Section E, Vol 68, Iss 8, Pp o2405-o2406 (2012)
In the title compound, C28H21ClN4O4, the benzofuran ring systems make dihedral angles of 7.43 (8) and 30.92 (9)° with the chloro-substituted benzene ring. The dihedral angle between the two benzofuran ring systems is 27.41 (7)°. The two benzofuran
Externí odkaz:
https://doaj.org/article/6e77c581e985405c8b3c3ad239a16cf0
Publikováno v:
Acta Crystallographica Section E, Vol 68, Iss 8, Pp o2407-o2408 (2012)
In the title molecular salt, C16H13N2OS+·HSO4−, the thiazolo[3,2-a]benzimidazolium ring system is roughly planar [maximum deviation = 0.046 (3) Å] and makes a dihedral angle of 58.22 (11)° with the benzene ring. The methoxy group is almost copla
Externí odkaz:
https://doaj.org/article/534f0f895add4e5e93cfcf85db01b4a0
Publikováno v:
Acta Crystallographica Section E, Vol 68, Iss 7, Pp o2260-o2261 (2012)
In the title compound, C16H14N2O4, the dihedral angle between the aromatic rings is 12.45 (6)°. The central C(=O)—N—N=C bridge is roughly planar (r.m.s. deviation = 0.0346 Å) and makes dihedral angles of 13.01 (7) and 0.56 (7)° with the attach
Externí odkaz:
https://doaj.org/article/0ede50f5dcce4994a2de4d461dba11fd
Autor:
Reham M. El-Meligy, Amani S. Awaad, Ahmed M. Alafeefy, Fatmah A.S. Alasmary, Saleh I. Alqasoumi
Publikováno v:
Saudi Pharmaceutical Journal, Vol 25, Iss 8, Pp 1125-1129 (2017)
The Novel target compounds (CP-1-7) were synthesized and tested at doses up to 1000 mg/kg for their entitled activities. They exerted promising results without any behavioral changes and mortality in mice. Therefore, according to the results obtained
Autor:
Fatima S. Alnahdi, Nadine M. S. Moubayed, Moustafa E. El-Araby, Abir Ben Bacha, Amr M. El-Araby, Ahmed M. Alafeefy, Fatmah A.S. Alasmary
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 1143-1151 (2017)
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 1143-1151 (2017)
Elevated blood glucose and increased activities of secreted phospholipase A2 (sPLA2) are strongly linked to coronary heart disease. In this report, our goal was to develop small heterocyclic compound that inhibit sPLA2. The title compounds were also
Autor:
Nahed N. E. El-Sayed, Andrew G. Mercader, Ahmed M. Alafeefy, Indira G. Shibi, Vijay H. Masand, Devidas T. Mahajan
Publikováno v:
Journal of Molecular Structure. 1130:711-718
In the present work, sixty substituted 2-Phenylimidazopyridines previously reported with potent anti-human African trypanosomiasis (HAT) activity were selected to build genetic algorithm (GA) based QSAR models to determine the structural features tha