Synthesis, molecular modelling, and biological evaluation of novel quinoxaline derivatives for treating type II diabetes

Autor: Fatmah Ali S. Alasmary, Dalal A. Abdullah, Vijay H. Masand, Abir Ben Bacha, Abdelsattar Mansour Omar Ebeid, Moustafa E. El-Araby, Ahmed M Alafeefy

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)

Quinoxalines are benzopyrazine derivatives with significant therapeutic impact in the pharmaceutical industry. They proved to be useful against inflammation, bacterial, fungal, viral infection, diabetes and other applications. Very recently, in Janua

Externí odkaz: https://doaj.org/article/ffec69356bab4219b307daf6812c7f51

Symmetric molecules with 1,4-triazole moieties as potent inhibitors of tumour-associated lactate dehydrogenase-A

Autor: Abdul-Malek S. Altamimi, Ahmed M. Alafeefy, Agnese Balode, Igor Vozny, Aleksandrs Pustenko, Mohey Eldin El Shikh, Fatmah A. S. Alasmary, Sherif A. Abdel-Gawad, Raivis Žalubovskis

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 147-150 (2018)

A series of symmetric molecules incorporating aryl or pyridyl moieties as central core and 1,4-substituted triazoles as a side bridge was synthesised. The new compounds were investigated as lactate dehydro-genase (LDH, EC 1.1.1.27) inhibitors. The ca

Externí odkaz: https://doaj.org/article/d98384a4355f4f28b80fc52997be5e32

Anti-ulcerogenic and anti-ulcerative colitis (UC) activities of seven amines derivatives

Autor: Amani S. Awaad, Ahmed M. Alafeefy, Fatmah A.S. Alasmary, Reham M. El-Meligy, Saleh I. Alqasoumi

Publikováno v: Saudi Pharmaceutical Journal, Vol 25, Iss 8, Pp 1125-1129 (2017)

The Novel target compounds (CP-1-7) were synthesized and tested at doses up to 1000 mg/kg for their entitled activities. They exerted promising results without any behavioral changes and mortality in mice. Therefore, according to the results obtained

Externí odkaz: https://doaj.org/article/89176b6bbe5645d7ad8bcd1b6072793a

New quinoxalinone inhibitors targeting secreted phospholipase A2 and α-glucosidase

Autor: Fatmah A. S. Alasmary, Fatima S. Alnahdi, Abir Ben Bacha, Amr M. El-Araby, Nadine Moubayed, Ahmed M. Alafeefy, Moustafa E. El-Araby

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 1143-1151 (2017)

Elevated blood glucose and increased activities of secreted phospholipase A2 (sPLA2) are strongly linked to coronary heart disease. In this report, our goal was to develop small heterocyclic compound that inhibit sPLA2. The title compounds were also

Externí odkaz: https://doaj.org/article/8cab571f7d2242e7b0e008bc771b6d4d

Aryl derivatives of 3H-1,2-benzoxathiepine 2,2-dioxide as carbonic anhydrase inhibitors

Autor: Anastasija Balašova, Mikhail Krasavin, Aleksandrs Pustenko, Raivis Žalubovskis, Claudiu T. Supuran, Ahmed M. Alafeefy, Alessio Nocentini

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 245-254 (2020)

A new series of homosulfocoumarins (3H-1,2-benzoxathiepine 2,2-dioxides) possessing various substitution patterns and moieties in the 7, 8 or 9 position of the heterocylic ring were prepared by original procedures and investigated for the inhibition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b4f299e27b89ef9bb2024913387524a
https://doi.org/10.1080/14756366.2019.1695795