Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Ahmed M, Gouda"'
Autor:
Ahmed M. Gouda, Ashraf E. Sileem, Hanan M. Elnahas, Ahmed E. Tawfik, Refaat A. Eid, Ayed A. Shati, Saleh M. Al-Qahtani, Samy A. Dawood, Mohammed A. Alshehri, Mohamed Eissa, Mohamed A. Soltan, Ahmed E. Noreldin, Amir Helmy Elwishahy, Essamedin M. Negm
Publikováno v:
Medicina, Vol 60, Iss 8, p 1346 (2024)
Background and Objectives: Ventilator-associated pneumonia (VAP) is a common complication in critically ill patients receiving mechanical ventilation. The incidence rates of VAP vary, and it poses significant challenges due to microbial resistance an
Externí odkaz:
https://doaj.org/article/f3752ba5372d45ad8ad0a92ed8e4c259
Autor:
Ahmed M. Gouda, Mohamed A. Soltan, Khalid Abd-Elghany, Ashraf E. Sileem, Hanan M. Elnahas, Marwa Abdel-Monem Ateya, Mahmoud H. Elbatreek, Khaled M. Darwish, Hanin A. Bogari, Manar O. Lashkar, Mohammed M. Aldurdunji, Sameh S. Elhady, Tarek A. Ahmad, Ahmed Mohamed Said
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Introduction:Klebsiella pneumoniae (K. pneumoniae) and Pseudomonas aeruginosa (P. aeruginosa) are the most common Gram-negative bacteria associated with pneumonia and coinfecting the same patient. Despite their high virulence, there is no effective v
Externí odkaz:
https://doaj.org/article/993fb5119913403e9533700e0e4c237b
Autor:
Mohammed Y. Behairy, Mohamed A. Soltan, Mohamed S. Adam, Ahmed M. Refaat, Ehab M. Ezz, Sarah Albogami, Eman Fayad, Fayez Althobaiti, Ahmed M. Gouda, Ashraf E. Sileem, Mahmoud A. Elfaky, Khaled M. Darwish, Muhammad Alaa Eldeen
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
The NRAS gene is a well-known oncogene that acts as a major player in carcinogenesis. Mutations in the NRAS gene have been linked to multiple types of human tumors. Therefore, the identification of the most deleterious single nucleotide polymorphisms
Externí odkaz:
https://doaj.org/article/608f9494b57e45638a0b7ad1939074dc
Autor:
Mohammed A.S. Abourehab, Alaa M. Alqahtani, Faisal A. Almalki, Ashraf N. Abdalla, Ahmed M. Gouda
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 4, Iss , Pp 100036- (2022)
In the present study, two new Schiff bases 10a,b were synthesized by the condensation of 9a,b with cinnamaldehyde. The chemical structures of 10a,b were confirmed using spectral (IR, mass, 1H NMR, 13C NMR, and DEPT C135) and elemental analysis. The e
Externí odkaz:
https://doaj.org/article/d42c4516ac41447c9aabec9e3fd7ea75
Autor:
Ahmed M. Shawky, Nashwa A. Ibrahim, Ashraf N. Abdalla, Mohammed A. S. Abourehab, Ahmed M. Gouda
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1312-1332 (2021)
In the present study, two new series of pyrrolizines bearing 3,4,5-trimethoxyphenyl moiety were designed, synthesised, and evaluated for their cytotoxic activity. The benzamide derivatives 16a–e showed higher cytotoxicity than their corresponding S
Externí odkaz:
https://doaj.org/article/b7aa083a55f3426d871c3f3786dfeea5
Autor:
Ahmed M. Shawky, Nashwa A. Ibrahim, Mohammed A. S. Abourehab, Ashraf N. Abdalla, Ahmed M. Gouda
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 15-33 (2021)
In the current study, virtual screening of a small library of 1302 pyrrolizines bearing urea/thiourea moieties was performed. The top-scoring hits were synthesised and evaluated for their cytotoxicity against three cancer (MCF-7, A2780, and HT29) and
Externí odkaz:
https://doaj.org/article/ff66a1b269f8469b88f7fd2224510c23
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 1001 (2022)
Janus kinase (JAK) is a family of cytoplasmic non-receptor tyrosine kinases that includes four members, namely JAK1, JAK2, JAK3, and TYK2. The JAKs transduce cytokine signaling through the JAK-STAT pathway, which regulates the transcription of severa
Externí odkaz:
https://doaj.org/article/accac52c55b747b4871cef3ad9252f32
Publikováno v:
Molecules, Vol 26, Iss 21, p 6677 (2021)
Targeting the EGFR with small-molecule inhibitors is a confirmed valid strategy in cancer therapy. Since the FDA approval of the first EGFR-TKI, erlotinib, great efforts have been devoted to the discovery of new potent inhibitors. Until now, fourteen
Externí odkaz:
https://doaj.org/article/3499b256055c44e789e51efe9a65e191
Autor:
Mohamed A. Soltan, Muhammad Alaa Eldeen, Nada Elbassiouny, Hasnaa L. Kamel, Kareem M. Abdelraheem, Hanaa Abd El-Gayyed, Ahmed M. Gouda, Mohammed F. Sheha, Eman Fayad, Ola A. Abu Ali, Khalid Abd El Ghany, Dalia A. El-damasy, Khaled M. Darwish, Sameh S. Elhady, Ashraf E. Sileem
Publikováno v:
Cells, Vol 10, Iss 11, p 3014 (2021)
During the current era of the COVID-19 pandemic, the dissemination of Mucorales has been reported globally, with elevated rates of infection in India, and because of the high rate of mortality and morbidity, designing an effective vaccine against muc
Externí odkaz:
https://doaj.org/article/dd6b0fcee57447549491a70f8859ea5a
Publikováno v:
Molecules, Vol 26, Iss 21, p 6423 (2021)
In the current study, a 2D similarity/docking-based study was used to predict the potential binding modes of icotinib, almonertinib, and olmutinib into EGFR. The similarity search of icotinib, almonertinib, and olmutinib against a database of 154 EGF
Externí odkaz:
https://doaj.org/article/3789cb7879d542b49ced84daf80db761