Výsledky vyhledávání - "Ahmed Kousba"

Autor: Marianne Scheel Fjording, Amanda Hays, Ahmed Kousba

Publikováno v: Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays ISBN: 9783030733179

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b93a64d2dc8a0c2acb2a5ba0d526419e
https://doi.org/10.1007/978-3-030-73317-9_100-1

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Phase I study of intravenously administered ATI-1123, a liposomal docetaxel formulation in patients with advanced solid tumors

Autor: Jessica Hart, Alain C. Mita, John Sarantopoulos, Ahmed Kousba, Kamalesh Kumar Sankhala, Laeeq Malik, Neil Senzer, John Charles, Nicole S. Gallegos, Gavin Anderson, Steven D. Weitman, Devalingam Mahalingam, Jon M. Rogers, John Nemunaitis

Publikováno v: Cancer Chemotherapy and Pharmacology. 74:1241-1250

ATI-1123 is a liposomal formulation of docetaxel and may be administered without the premedications and hypersensitivity reactions. This Phase I study examines the safety, tolerability, pharmacokinetics (PKs), and antitumor activity of ATI-1123.Patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d21f57e0fd0cf4b118daec858f85623
https://doi.org/10.1007/s00280-014-2602-x

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A 9-Month Toxicity and Toxicokinetic Assessment of Subcutaneous Pegylated Human C-peptide (CBX129801) in Cynomolgus Monkeys

Autor: Dennis Naas, Michelle Mazzoni, Ahmed Kousba, Teresa Morris

Publikováno v: International journal of toxicology. 34(4)

C-peptide is formed in the biosynthesis of insulin and is therefore deficient in patients with type 1 diabetes mellitus. A pegylated form of human synthetic C-peptide (CBX129801) has been developed to extend the half-life of the native peptide and is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398a5e7f56669b571fc2ef84e0096729
https://pubmed.ncbi.nlm.nih.gov/26111539

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Continuous system modeling of equilibrium dialysis for determinations of tissue partitioning of parathion and paraoxon

Autor: Lester G. Sultatos, Ahmed Kousba

Publikováno v: Toxicology Letters. 133:153-159

A tissue/blood partition coefficient, defined as the ratio of tissue chemical concentration to that of the venous outflow of the tissue when at equilibrium, is an important parameter required for physiological based pharmacokinetic models. While many

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f26048a95d9711ed05131899f44ffb9
https://doi.org/10.1016/s0378-4274(02)00131-5

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Cyclic conversion of the novel Src kinase inhibitor [7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine (TG100435) and Its N-oxide metabolite by flavin-containing monoxygenases and cytochrome P450 reductase

Autor: Ahmed, Kousba, Richard, Soll, Shiyin, Yee, Michael, Martin

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 35(12)

[7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine (TG100435) is a novel multi-targeted Src family kinase inhibitor with demonstrated anticancer activity in preclinical species. Potent kinase inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bcc64ff8835e31cbc34ec8cdf8954751
https://pubmed.ncbi.nlm.nih.gov/17881660

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Metabolism and pharmacokinetics of a novel Src kinase inhibitor TG100435 ([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and its active N-oxide metabolite TG100855 ([7-(2,6-dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)

Autor: Steven X, Hu, Richard, Soll, Shiyin, Yee, Daniel L, Lohse, Ahmed, Kousba, Binqi, Zeng, Xiyun, Yu, Andrew, McPherson, Joel, Renick, Jianguo, Cao, Arek, Tabak, John, Hood, John, Doukas, Glenn, Noronha, Michael, Martin

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 35(6)

TG100435 ([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) is a novel multitargeted, orally active protein tyrosine kinase inhibitor. The inhibition constants (K(i)) of TG100435 against Src, Lyn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8c7981b80db1a74ec1e48f4001aefc4f
https://pubmed.ncbi.nlm.nih.gov/17371799

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Interactions of rat brain acetylcholinesterase with the detergent Triton X-100 and the organophosphate paraoxon

Autor: Lester G. Sultatos, Clint Rosenfeld, Ahmed Kousba

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 63(2)

Inhibition of the critical enzyme acetylcholinesterase (E.C. 3.1.1.7) with subsequent cholinergic crisis is the mechanism of acute toxicity of the organophosphorus insecticides (B. E. Mileson et al., 1998, Toxicol. Sci.41, 8-20). Consequently, measur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bce2f846af765843c7aaafd07f43d7e
https://pubmed.ncbi.nlm.nih.gov/11568364

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Akademický článek

Development of Prodrug 4-Chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}-1,2,4-benzotriazin-7-yl)phenyl Benzoate (TG100801): A Topically Administered Therapeutic Candidate in Clinical Trials for the Treatment of Age-Related Macular...

Publikováno v: Journal of Medicinal Chemistry; Feb2008, Vol. 51 Issue 6, p1546-1559, 14p

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