Unraveling the role of γδ T cells in the pathogenesis of an oncogenic avian herpesvirus

Autor: Mohammad A. Sabsabi, Ahmed Kheimar, Yu You, Dominik von La Roche, Sonja Härtle, Thomas W. Göbel, Theresa von Heyl, Benjamin Schusser, Benedikt B. Kaufer

Publikováno v: mBio, Vol 15, Iss 8 (2024)

ABSTRACT Marek’s disease virus (MDV) is an oncogenic alphaherpesvirus that causes deadly lymphomas in chickens. In chickens, up to 50% of all peripheral T cells are gamma delta (γδ) T cells. Until now, their role in MDV pathogenesis and tumor for

Externí odkaz: https://doaj.org/article/0c96e4576b904e06a16d362eecd77b83

In vitro infection of primary chicken lymphocytes with Marek’s disease virus

Autor: Luca D. Bertzbach, Marina Kohn, Yu You, Lisa Kossak, Mohammad A. Sabsabi, Ahmed Kheimar, Sonja Härtle, Benedikt B. Kaufer

Publikováno v: STAR Protocols, Vol 4, Iss 2, Pp 102343- (2023)

Summary: Marek’s disease virus (MDV) is a highly oncogenic alphaherpesvirus that infects immune cells and causes a deadly lymphoproliferative disease in chickens. Cytokines and monoclonal antibodies promote the survival of chicken lymphocytes in vi

Externí odkaz: https://doaj.org/article/6b80953abc8044f2bb0169e3344fbe22

A Genetically Engineered Commercial Chicken Line Is Resistant to Highly Pathogenic Avian Leukosis Virus Subgroup J

Autor: Ahmed Kheimar, Romina Klinger, Luca D. Bertzbach, Hicham Sid, You Yu, Andelé M. Conradie, Benjamin Schade, Brigitte Böhm, Rudolf Preisinger, Venugopal Nair, Benedikt B. Kaufer, Benjamin Schusser

Publikováno v: Microorganisms, Vol 9, Iss 5, p 1066 (2021)

Viral diseases remain a major concern for animal health and global food production in modern agriculture. In chickens, avian leukosis virus subgroup J (ALV-J) represents an important pathogen that causes severe economic loss. Until now, no vaccine or

Externí odkaz: https://doaj.org/article/3fb697d80e1f490082f724186f00830c

Telomeres and Telomerase: Role in Marek’s Disease Virus Pathogenesis, Integration and Tumorigenesis

Autor: Ahmed Kheimar, Renato L. Previdelli, Darren J. Wight, Benedikt B. Kaufer

Publikováno v: Viruses, Vol 9, Iss 7, p 173 (2017)

Telomeres protect the ends of vertebrate chromosomes from deterioration and consist of tandem nucleotide repeats (TTAGGG)n that are associated with a number of proteins. Shortening of the telomeres occurs during genome replication, thereby limiting t

Externí odkaz: https://doaj.org/article/7efa640f619249e2adb55e162f73eb4a

Development of a PROTAC-Based Targeting Strategy Provides a Mechanistically Unique Mode of Anti-Cytomegalovirus Activity

Autor: William D. Rawlinson, Markus Wild, Stuart T. Hamilton, Ahmed Kheimar, Manfred Marschall, Benedikt B. Kaufer, Jasmine E. L. Follett, Lars Herrmann, Jintawee Kicuntod, Svetlana B. Tsogoeva, Nadine Brückner, Friedrich Hahn, Christina Wangen

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 12858, p 12858 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12858

Human cytomegalovirus (HCMV) is a major pathogenic herpesvirus that is prevalent worldwide and it is associated with a variety of clinical symptoms. Current antiviral therapy options do not fully satisfy the medical needs; thus, improved drug classes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025fe4cd9b48d660f9617837c866f6cb
https://www.mdpi.com/1422-0067/22/23/12858