Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ahmed Khairallah Mahdi"'
Autor:
Marco Youssef William Zaki, Ahmed Khairallah Mahdi, Gillian Lucinda Patman, Anna Whitehead, João Pais Maurício, Misti Vanette McCain, Despina Televantou, Sameh Abou-Beih, Erik Ramon-Gil, Robyn Watson, Charlotte Cox, Jack Leslie, Caroline Wilson, Olivier Govaere, John Lunec, Derek Austin Mann, Sirintra Nakjang, Fiona Oakley, Ruchi Shukla, Quentin Mark Anstee, Dina Tiniakos, Helen Louise Reeves
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract The prevalence of obesity and non-alcoholic fatty liver disease (NAFLD) associated hepatocellular carcinoma (HCC) is rising, even in the absence of cirrhosis. We aimed to develop a murine model that would facilitate further understanding of
Externí odkaz:
https://doaj.org/article/c2466e2014fe4723915552556b300a2b
Autor:
Caroline L. Wilson, Olivier Govaere, A. Whitehead, Ahmed Khairallah Mahdi, Jack Leslie, Sirintra Nakjang, Robyn Watson, G.L. Patman, Marco Y W Zaki, Charlotte Cox, Erik Ramon-Gil, João Maurício, John Lunec, Sameh Abou-Beih, Fiona Oakley, Quentin M. Anstee, Ruchi Shukla, Helen L. Reeves, Misti Vanette McCain, Derek A. Mann, Despina Televantou, Dina Tiniakos
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
The prevalence of obesity and non-alcoholic fatty liver disease (NAFLD) associated hepatocellular carcinoma (HCC) is rising, even in the absence of cirrhosis. We aimed to develop a murine model that would facilitate further understanding of NAFLD-HCC
Autor:
Penny E. Lovat, Ahmed Khairallah Mahdi, Chiao-En Wu, Arman Esfandiari, John Lunec, Nan Wang, Yi-Hsuan Ho, Erhan Aptullahoglu
Publikováno v:
British Journal of Cancer
Background: Cutaneous melanoma is the most serious skin malignancy and new therapeutic strategies are needed for advanced melanoma. TP53 mutations are rare in cutaneous melanoma and hence activation of wild-type p53 is a potential therapeutic strateg
Autor:
Eric H. Karunanayake, Arman Esfandiari, Ahmed Khairallah Mahdi, C-E Wu, S.T. de Silva, John Lunec, Vahinipriya Manoharan, M Zanjirband, Kamani H. Tennekoon
Publikováno v:
Cancer Research. 77:P3-07
Background The tumor suppressor p53 is a central hub in molecular signaling pathways that control the integrity of the human genome. The p53 protein functions as a transcription factor and increases the expression of many cellular genes which contrib
Autor:
D. Tiniakos, Quentin M. Anstee, Fiona Oakley, John Lunec, Ruchi Shukla, Helen L. Reeves, Ahmed Khairallah Mahdi, Simon Cockell, Marco Y W Zaki
Publikováno v:
Journal of Hepatology. 68:S49
Autor:
Chiao-En Wu, Yi-Hsuan Ho, Arman Esfandiari, John Lunec, Colin Shepherd, Erhan Aptullahoglu, John Wen-Cheng Chang, Penny E. Lovat, Ahmed Khairallah Mahdi
Publikováno v:
Cancer Research. 77:2151-2151
Cutaneous melanoma is the most serious skin malignancy. The current study aimed to investigate the WIP1 inhibitor GSK2830371 and MDM2-p53 antagonists (nutlin-3, RG7388 and HDM201) alone and in combination treatment in cutaneous melanoma cell lines an