CD38‐NADase is a new major contributor to Duchenne muscular dystrophic phenotype

Autor: Antoine de Zélicourt, Abdallah Fayssoil, Mbarka Dakouane‐Giudicelli, Isley De Jesus, Ahmed Karoui, Faouzi Zarrouki, Florence Lefebvre, Arnaud Mansart, Jean‐Marie Launay, Jerome Piquereau, Mariana G Tarragó, Marcel Bonay, Anne Forand, Sophie Moog, France Piétri‐Rouxel, Elise Brisebard, Claudia C S Chini, Sonu Kashyap, Matthew J Fogarty, Gary C Sieck, Mathias Mericskay, Eduardo N Chini, Ana Maria Gomez, José‐Manuel Cancela, Sabine de la Porte

Publikováno v: EMBO Molecular Medicine, Vol 14, Iss 5, Pp 1-23 (2022)

Abstract Duchenne muscular dystrophy (DMD) is characterized by progressive muscle degeneration. Two important deleterious features are a Ca2+ dysregulation linked to Ca2+ influxes associated with ryanodine receptor hyperactivation, and a muscular nic

Externí odkaz: https://doaj.org/article/ff8aa5831114408f802cc62d7a45fce4

Spatiotemporal AMPKα2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only

Autor: Mélanie Gressette, Eric Jacquet, Marta Novotova, Vladimir Veksler, Mathias Mericskay, Kaveen Bedouet, Audrey Solgadi, Ahmed Karoui, Maria-Nieves Sanz, Anne Garnier, Renée Ventura-Clapier, Lucile Grimbert, Catherine Rucker-Martin, Christophe Lemaire, Susana Gomez, Jérôme Piquereau

Publikováno v: Biology of Sex Differences, Vol 12, Iss 1, Pp 1-24 (2021)
Biology of Sex Differences
Biology of Sex Differences, BioMed Central, 2021, 12 (1), ⟨10.1186/s13293-021-00394-z⟩
Biology of Sex Differences, 2021, 12 (1), ⟨10.1186/s13293-021-00394-z⟩

Background The AMP-activated protein kinase (AMPK) is a major regulator of cellular energetics which plays key role in acute metabolic response and in long-term adaptation to stress. Recent works have also suggested non-metabolic effects. Methods To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f97537c64633a4b195360395a4118af9
https://doaj.org/article/81438108d8ef4b59a82a8ad86e49fea4

Triazole fungicide tebuconazole induces apoptosis through ROS-mediated endoplasmic reticulum stress pathway

Autor: Yosra Ben Othmène, Kevin Monceaux, Anissa Belhadef, Ahmed Karoui, Intidhar Ben Salem, Manel Boussabbeh, Salwa Abid-Essefi, Christophe Lemaire

Publikováno v: Environmental toxicology and pharmacology. 94

Tebuconazole (TEB) is a common triazole fungicide that has been widely applied in the treatment of fungal diseases. It is reported that TEB could exert harmful effects on mammals' health. However, the molecular mechanism involved in TEB toxicity rema

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d42437d16e5a403d86586c145a422a39
https://pubmed.ncbi.nlm.nih.gov/35753672

NMRK2 Gene Is Upregulated in Dilated Cardiomyopathy and Required for Cardiac Function and NAD Levels during Aging

Autor: Gareth G. Lavery, Jocelyne Blanc, Cynthia Tannous, Nathalie Mougenot, Mathias Mericskay, Dario Coletti, Robin Deloux, Ahmed Karoui, Zhenlin Li, Dean J. Burkin

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 7
International Journal of Molecular Sciences, MDPI, 2021, 22 (7), pp.3534. ⟨10.3390/ijms22073534⟩
International Journal of Molecular Sciences, 2021, 22 (7), pp.3534. ⟨10.3390/ijms22073534⟩
International Journal of Molecular Sciences, Vol 22, Iss 3534, p 3534 (2021)

Dilated cardiomyopathy (DCM) is a disease of multifactorial etiologies, the risk of which is increased by male sex and age. There are few therapeutic options for patients with DCM who would benefit from identification of common targetable pathways. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02562f17130a1721f3a0b3dbad4614cb

An integrated functional and transcriptomic analysis reveals that repeated exposure to diesel exhaust induces sustained mitochondrial and cardiac dysfunctions

Autor: Fabrice Cazier, Malik Mekki, Clément Crochemore, François Sichel, Cécile Corbière, Paul Mulder, Olivier Fardel, David Preterre, Vincent Richard, Ahmed Karoui, Cathy Vendeville, Jean-Marie Vaugeois, Christelle Monteil, Dorothée Dewaele, Valérie Lecureur

Publikováno v: Environmental Pollution
Environmental Pollution, Elsevier, 2019, 246, pp.518-526. ⟨10.1016/j.envpol.2018.12.049⟩
Environmental Pollution, 2019, 246, pp.518-526. ⟨10.1016/j.envpol.2018.12.049⟩

International audience; Diesel exhaust (DE) contributes to air pollution, an important risk factor for cardiovasculardiseases. However, the mechanisms by which DE exposure induces cardiovasculardysfunction remain unknown and there is still debate on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aaefc1455f0f75d747da749b6762952
https://pubmed.ncbi.nlm.nih.gov/30583160