Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ahmed K. Elsayed"'
Publikováno v:
Stem Cell Research, Vol 79, Iss , Pp 103470- (2024)
Autism spectrum disorder (ASD) is a complex developmental disorder characterized by challenges with social interactions and restricted/repetitive behaviors. Here, we recruited nine Qatari children of Arab ethnicity (males, aged 2–4 years), includin
Externí odkaz:
https://doaj.org/article/ba38a649bf8f4afd93db98c81129c9ac
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-22 (2023)
Abstract Background Our recent studies have demonstrated the crucial involvement of FOXA2 in the development of human pancreas. Reduction of FOXA2 expression during the differentiation of induced pluripotent stem cells (iPSCs) into pancreatic islets
Externí odkaz:
https://doaj.org/article/1c67c65a3a854c079aca85b1e4c6d83a
Autor:
Bushra Memon, Ahmed K. Elsayed, Ilham Bettahi, Noor Suleiman, Ihab Younis, Eman Wehedy, Abdul Badi Abou-Samra, Essam M. Abdelalim
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-14 (2022)
Abstract Background The genetic factors associated with insulin resistance (IR) are not well understood. Clinical studies on first-degree relatives of type 2 diabetic (T2D) patients, which have the highest genetic predisposition to T2D, have given in
Externí odkaz:
https://doaj.org/article/b02791bcd2fb4565811b7e8ddb8111ec
Publikováno v:
Cell Death and Disease, Vol 12, Iss 1, Pp 1-17 (2021)
Abstract FOXA2 has been identified as an essential factor for pancreas development and emerging evidence supports an association between FOXA2 and diabetes. Although the role of FOXA2 during pancreatic development is well-studied in animal models, it
Externí odkaz:
https://doaj.org/article/222970af73314227aa03a1724d9032bf
Publikováno v:
Stem Cell Research, Vol 56, Iss , Pp 102500- (2021)
Autism spectrum disorder (ASD) is a childhood-onset neurodevelopmental disorder characterized by social interaction, behavior, and communication challenges. Here, we generated an induced pluripotent stem cell (iPSC) line, QBRIi013-A using a non-integ
Externí odkaz:
https://doaj.org/article/77c154abc38a443aab3d0ad47216e0d4
Publikováno v:
Stem Cell Research, Vol 54, Iss , Pp 102433- (2021)
Recessive mutations in the glucose transporter gene SLC2A2 (GLUT2) lead to permanent neonatal diabetes (PNDM) and Fanconi Bickel Syndrome (FBS). Here, we generated an induced pluripotent stem cell (iPSC) line, QBRIi012-A, from a 24-month-old boy with
Externí odkaz:
https://doaj.org/article/9cd51076aace4deeb798533c4c86165c
Autor:
Yasmin W. Abu Aqel, Gowher Ali, Ahmed K. Elsayed, Sara Al-Khawaga, Khalid Hussain, Essam M. Abdelalim
Publikováno v:
Stem Cell Research, Vol 48, Iss , Pp 101991- (2020)
Heterozygous and homozygous mutations in the glucokinase (GCK) gene leads to maturity-onset diabetes of the young type 2 (MODY2) and permanent neonatal diabetes (PNDM), respectively. Here, we report the generation of two induced pluripotent stem cell
Externí odkaz:
https://doaj.org/article/dcf0f54480344710b24cf342c2a90890
Publikováno v:
Stem Cell Research, Vol 44, Iss , Pp - (2020)
Fanconi Bickel Syndrome (FBS) is an autosomal recessive disease resulting from mutations in the SLC2A2 gene, encoding the GLUT2. FBS patients develop diabetes mellitus. Using non-integrating Sendai virus, we generated an induced pluripotent stem cell
Externí odkaz:
https://doaj.org/article/aa86b87f3f92416ca89d45ba41e66784
Autor:
Ahmed K. Elsayed, Maryam Aghadi, Gowher Ali, Sara Al-Khawaga, Khalid Hussain, Essam M. Abdelalim
Publikováno v:
Stem Cell Research, Vol 42, Iss , Pp - (2020)
FOXA2 is a transcription factor, playing an important role during development. We established an induced pluripotent stem cell (iPSC) line, QBRIi009-A, using non-integrating Sendai virus from a 4-year-old boy, displaying a complex clinical phenotype.
Externí odkaz:
https://doaj.org/article/c77db25e2eef4084b007d88cca76d86f
Publikováno v:
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-11 (2018)
Abstract Background The expression of a specific combination of transcription factors (TFs) in the multipotent progenitor cells (MPCs) is critical for determining pancreatic cell fate. NKX6.1 expression in PDX1+ MPCs is required for functional β cel
Externí odkaz:
https://doaj.org/article/de8ea88ea2924002847db37cfd23546f